{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:05:56Z","timestamp":1771653956003,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"15","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDT"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>The incidence of inflammatory bowel disease (IBD) continues to rise\nworldwide. Despite the advances in pharmacotherapy, the etiopathogenesis of Crohn\u2019s disease\n(CD) and ulcerative colitis (UC) remains underexplained. The migratory waves are a challenging\nsetting to analyze the evolution of IBD prevalence and to infer its triggering factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Our study aimed to overview the literature regarding IBD prevalence and phenotype in\nfirst- and second-generation migrants Also, we aimed to summarize the migration history and to\ndraw a possible correlation with IBD distribution.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A non-systematic review was performed following electronic (PubMed and Web of Science)\nand manual searches on relevant topics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Overall, first-generation migrants tend to maintain the IBD risk of the native country. On\nthe following generation, the risk tends to converge to that of the destination country. Earlier age at\nmigration modulates IBD risk, suggesting that the degree of exposure to environmental and socio-economic\nfactors can be decisive for disease progression. In general, CD needs more time to reach a\ndisease burden similar to that of the host country, indicating that UC may be more affected by nongenetic\nfactors and genetic-nongenetic interactions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> IBD phenotypes and natural history vary in migrants and according to ethnicity; however,\nthe trends are not consensual among cohorts. Further studies are warranted to analyze the effect\nof genetic background and environmental risk factors in different ethnic groups, providing evidence\nto move towards the identification of at-risk individuals, prevention, and earlier diagnosis of\nIBD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389450122666210203193817","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T16:46:21Z","timestamp":1612457181000},"page":"1706-1715","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?"],"prefix":"10.2174","volume":"22","author":[{"given":"Gionata","family":"Fiorino","sequence":"first","affiliation":[{"name":"IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center \u2013 IRCCS, Rozzano, Milan, Italy"}]},{"given":"Maria M.","family":"Estevinho","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Diogo J.M.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit, Sao Joao Hospital University Center, Porto, Portugal"}]},{"given":"Filippo","family":"Chersi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}]},{"given":"Mariangela","family":"Allocca","sequence":"additional","affiliation":[{"name":"IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center \u2013 IRCCS, Rozzano, Milan, Italy"}]},{"given":"Miguel T.","family":"Souto","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit, Sao Joao Hospital University Center, Porto, Portugal"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center \u2013 IRCCS, Rozzano, Milan, Italy"}]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit, Sao Joao Hospital University Center, Porto, Portugal"}]}],"member":"965","container-title":["Current Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/191108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/191108\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/191108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T14:10:44Z","timestamp":1634479844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/191108\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":0,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389450122666210203193817","relation":{},"ISSN":["1389-4501"],"issn-type":[{"value":"1389-4501","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}