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In this way, plant metabolites such\nas essential oils have emerged as promising agents due to their biological effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Bearing in mind that several essential oils are characterized by high amounts of phenylpropanoids,\nwhich may play a crucial role in the activity of these volatile extracts, a comprehensive and\nsystematic review focusing on the cardiovascular effects of phenylpropanoid-rich essential oils is presented.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Popular search engines including PubMed, Science Direct, Scopus and Google Scholar were\nconsulted and papers from 2000 onwards were selected. Non-volatile phenylpropanoids were not considered\nin this review.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>A compilation of the current knowledge on this thematic pointed out beneficial effects for\nvolatile phenylpropanoids namely hypotensive, vasorelaxant, antiplatelet aggregation, antidyslipidaemic\nand antidiabetic, as well as protective properties against ischemia\/reperfusion injury and heart hypertrophy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>A better understanding of the protective effects of phenylpropanoids on the cardiovascular\nsystem is presented, thus paving the way towards future research on plant-based therapies for cardiovascular\ndiseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389557519666190620091915","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T12:18:45Z","timestamp":1561033125000},"page":"1459-1471","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System"],"prefix":"10.2174","volume":"19","author":[{"given":"Jorge M.","family":"Alves-Silva","sequence":"first","affiliation":[{"name":"iCBR, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba, Coimbra, Portugal"}]},{"given":"M\u00f3nica","family":"Zuzarte","sequence":"additional","affiliation":[{"name":"iCBR, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba, Coimbra, Portugal"}]},{"given":"Carla","family":"Marques","sequence":"additional","affiliation":[{"name":"iCBR, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba, Coimbra, Portugal"}]},{"given":"Henrique","family":"Gir\u00e3o","sequence":"additional","affiliation":[{"name":"iCBR, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba, Coimbra, Portugal"}]},{"given":"L\u00edgia","family":"Salgueiro","sequence":"additional","affiliation":[{"name":"CIEPQPF and Faculty of Pharmacy, University of Coimbra, Azinhaga de Sta Comba, Coimbra, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","year":"2017","unstructured":"Cardiovascular diseases (CVDs).(accessed January 14, 2019) 2017"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1093\/eurheartj\/ehu299","volume":"35","author":"Nichols M.","year":"2014","unstructured":"Nichols M.; Townsend N.; Scarborough P.; Rayner M.; Cardiovascular disease in Europe 2014: Epidemiological update. 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