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Green tea has been studied\nfor breast cancer chemopreventive and possibly chemotherapeutic effects due to its high content in\npolyphenolic compounds, including epigallocatechin-3-gallate (EGCG).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method::<\/jats:title>\n<jats:p>This review is based on literature research that included papers registered on the Medline\u00ae\ndatabase. The research was conducted through PubMed, applying the following query: \u201cEGCG\u201dAND\n\"breast cancer\u201d. The result was a total of 88 articles in which this review stands on.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results::<\/jats:title>\n<jats:p>In vitro, EGCG shows antioxidant or pro-oxidant properties, depending on the concentration\nand exposure time. EGCG blocks cell cycle progression and modulates signaling pathways that affect\ncell proliferation and differentiation. EGCG also induces apoptosis, negatively modulates different\nsteps involved in metastasis, and targets angiogenesis by inhibiting VEGF transcription. In vivo investigations\nhave shown that oral administration of EGCG results in the reduction of tumor growth and in\nantimetastatic and antiangiogenic effects in animal xenograft and allograft models.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Discussion::<\/jats:title>\n<jats:p>Much remains unknown about the molecular mechanisms involved in the protective effects\nof EGCG on mammary carcinogenesis. In addition, more studies in vivo are necessary to determine\nthe potential toxicity of EGCG at higher doses and to elucidate its interactions with other drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion::<\/jats:title>\n<jats:p>A protective effect of EGCG has been shown in different experimental models and under\ndifferent experimental conditions, suggesting clinical implications of EGCG for breast cancer prevention\nand therapy. The data presented in this review support the importance of further investigations.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389557520999201211194445","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T10:53:16Z","timestamp":1608029596000},"page":"883-898","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The Role of EGCG in Breast Cancer Prevention and Therapy."],"prefix":"10.2174","volume":"21","author":[{"given":"Adriana","family":"Romano","sequence":"first","affiliation":[{"name":"Faculty of Medicine of University of Porto, Porto,Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-3416","authenticated-orcid":true,"given":"F\u00e1tima","family":"Martel","sequence":"additional","affiliation":[{"name":"Department of Biomedicine-Unit of Biochemistry, Faculty of Medicine of University of Porto, Porto, Portugal and Instituto de Investigacao e Inovacao em Saude(i3S), University of Porto, Porto,Portugal"}]}],"member":"965","reference":[{"key":"ref=1","author":"Organization W.H.","unstructured":"Organization W.H.;  Breast Cancer https:\/\/www.who.int\/cancer\/prevention\/diagnosis-screening\/breast-cancer\/en\/"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1093\/jn\/132.8.2307","volume":"132","author":"Sartippour M.R.","year":"2002","unstructured":"Sartippour M.R.; Shao Z.M.; Heber D.; Beatty P.; Zhang L.; Liu C.; Ellis L.; Liu W.; Go V.L.; Brooks M.N.; Green tea inhibits Vascular Endothelial Growth Factor (VEGF) induction in human breast cancer cells. 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