{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T04:33:16Z","timestamp":1722313996425},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2021,6,2]]},"abstract":"<jats:sec>\n<jats:title \/>\n<jats:p>Aging is a complex multifactorial process that, although universal, is not fully\nunderstood. It is known that the impact of aging on health is influenced by multiple\nfactors, such as sex, race, income, and education, and that age-related diseases are\nstrongly associated with the way people get old. The knowledge of biological aging and\nits comparison to the chronological age is a paramount contributor to predict the\nmetabolic decline and the onset of age-related diseases.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title \/>\n<jats:p>As aging processes observed in the whole human organism are somehow the reflection\nof what happens in each cell type, it is possible to study the aging process using cell\nlines, such as fibroblasts.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title \/>\n<jats:p>Metabolomics analysis of cell lines, namely fibroblasts, gives inputs to personalized or\nintegrative medicine; in fact, cell metabolomics is an emerging field that addresses\nfundamental biological and metabolic questions using modern \"omic\" techniques as\nFTIR, NMR or MS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title \/>\n<jats:p>This paper revises the relevance of using fibroblasts as cell models to study the\nmetabolome of aging.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1566524020999200831120852","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T08:25:37Z","timestamp":1598948737000},"page":"300-317","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Study Aging by Fibroblasts Metabolome"],"prefix":"10.2174","volume":"21","author":[{"given":"Ana","family":"Rocha","sequence":"first","affiliation":[{"name":"iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"}]},{"given":"Sandra","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"}]},{"given":"Alexandra","family":"Nunes","sequence":"additional","affiliation":[{"name":"iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"}]}],"member":"965","container-title":["Current Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185409\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T19:38:37Z","timestamp":1622835517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185409\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,2]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1566524020999200831120852","relation":{},"ISSN":["1566-5240"],"issn-type":[{"value":"1566-5240","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}