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Activation of SAC relies on the assembly of the mitotic\ncheckpoint complex (MCC), which requires conformational change from inactive open Mad2 (OMad2)\nto the active closed Mad2 (C-Mad2) at unattached kinetochores. The Mad2-binding protein\np31&lt;sup&gt;comet&lt;\/sup&gt; plays a key role in controlling timely mitotic exit by promoting SAC silencing, through preventing\nMad2 activation and promoting MCC disassembly. Besides, increasing evidences highlight\nthe p31&lt;sup&gt;comet&lt;\/sup&gt; potential as target for cancer therapy. Here, we provide an updated overview of the functional\nsignificance of p31&lt;sup&gt;comet&lt;\/sup&gt; in mitotic progression, and discuss the potential of deregulated expression\nof p31&lt;sup&gt;comet&lt;\/sup&gt; in cancer and in therapeutic strategies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568009621666210129095726","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T13:10:18Z","timestamp":1611925818000},"page":"401-415","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Mad2-Binding Protein p31comet as a Potential Target for Human Cancer Therapy"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-792X","authenticated-orcid":true,"given":"Ana C.","family":"Henriques","sequence":"first","affiliation":[{"name":"Instituto de Investigacao e Formacao Avancada em Ciencias e Tecnologias da Saude, Instituto Universitario de Ciencias da Saude, CESPU, Gandra,Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0694-7321","authenticated-orcid":true,"given":"Patr\u00edcia M. 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