{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:25:37Z","timestamp":1773383137742,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2018,5,14]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>The Head and Neck Squamous Cell Cancer (HNSCC) is the most common type of head and\nneck cancer (more than 90%), and all over the world more than a half million people have been developing\nthis cancer in the last years. This type of cancer is usually marked by a poor prognosis with a really\nsignificant morbidity and mortality. Cetuximab received early favor as an exciting and promising new\ntherapy with relatively mild side effect, and due to this, received authorization in 2004 from the European\nMedicines Agency (EMA) and in 2006 from the Food and Drug Association (FDA) for the treatment\nof patients with squamous cell cancer of the head and neck in combination with radiation therapy\nfor locally advanced disease. In this work we will review the application and the efficacy of the Cetuximab\nin the treatment of the HNSCC.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026618666180112162412","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T07:35:48Z","timestamp":1516001748000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cetuximab and the Head and Neck Squamous Cell Cancer"],"prefix":"10.2174","volume":"18","author":[{"given":"Riccardo","family":"Concu","sequence":"first","affiliation":[{"name":"REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal"}]},{"given":"M. Natalia D.S.","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal"}]}],"member":"965","container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/159023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/159023\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/159023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T09:08:24Z","timestamp":1608973704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/159023\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5,14]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1568026618666180112162412","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5,14]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2017-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}