{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:57:03Z","timestamp":1775019423842,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"15","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2018,11,16]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Leishmaniasis is a neglected disease caused by protozoan belonging to the Leishmania genus.\nThere are at least 16 pathogenic species for humans that are able to cause different clinical forms, such\nas cutaneous or visceral leishmaniasis. In spite of the different species and clinical forms, the treatment\nis performed with few drug options that, in most cases, are considered outdated. In addition, patients\nunder classical treatment show serious side effects during drug administration, moreover parasites are\nable to become resistant to medicines. Thus, it is believed and well accepted that is urgent and necessary\nto develop new therapeutic options to overpass these concerns about conventional therapy of leishmaniasis.\nThe present review will focus on the efficacy, side effects and action mechanism of classic drugs\nused in the treatment of leishmaniasis, as well as the importance of traditional knowledge for directing a\nrational search toward the discovery and characterization of new and effective molecules (in vivo assays)\nfrom plants to be used against leishmaniasis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026618666181002114448","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T11:48:45Z","timestamp":1538480925000},"page":"1275-1286","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Conventional Versus Natural Alternative Treatments for Leishmaniasis: A Review"],"prefix":"10.2174","volume":"18","author":[{"given":"Luiz Felipe Domingues","family":"Passero","sequence":"first","affiliation":[{"name":"Institute of Biosciences, Sao Paulo State University (UNESP), Sao Vicente. Praca Infante Dom Henrique, s\/n, 11330- 900 Sao Vicente, SP, Brazil"}]},{"given":"Lucas Antal","family":"Cruz","sequence":"additional","affiliation":[{"name":"Institute of Biosciences, Sao Paulo State University (UNESP), Sao Vicente. Praca Infante Dom Henrique, s\/n, 11330- 900 Sao Vicente, SP, Brazil"}]},{"given":"Gabriela","family":"Santos-Gomes","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisboa, Portugal"}]},{"given":"Eliana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Center for Ethnobotanical and Ethnopharmacoly Studies (CEE), Institute of Environmental Sciences, Chemical and Pharmaceutical, Universidade Federal de Sao Paulo (UNIFESP) 04021-001, Brazil"}]},{"given":"M\u00e1rcia Dalastra","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory of Pathology of Infectious Diseases (LIM50), Medical School of Sao Paulo University, Av. Dr. Arnaldo, 455. Cerqueira Cesar, S\u00e3o Paulo, 01246- 903, SP, Brazil"}]},{"given":"Jo\u00e3o Henrique Ghilardi","family":"Lago","sequence":"additional","affiliation":[{"name":"Center of Natural Sciences and Humanities, Federal University of ABC, Santo Andre, Sao Paulo, 09210-180, Brazil"}]}],"member":"965","container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/165835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/165835\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/165835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T09:06:58Z","timestamp":1608973618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/165835\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,16]]},"references-count":0,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,11,16]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1568026618666181002114448","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,16]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}