{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:22:07Z","timestamp":1768771327129,"version":"3.49.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"25","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Computer-aided design of new drugs is an exponentially growing field, especially in the\nlast decade. The support of theoretical tools may accelerate the drug discovery process, which is a\nlong and very expensive journey. Tools as QSAR and docking calculations are on the top of the list\nfor helping medicinal chemists to find more potent and selective molecules as potential leads for\nfacing challenging diseases. Coumarins have been an important source of inspiration for the design\nof new drugs. Due to their chemical properties and their affinity to some targets, special attention\nhas been paid to their role against neurodegenerative diseases. Therefore, the authors provide an\noverview of the scientific reports describing the research and development of new drug design\ntools supporting the discovery of coumarins as enzymatic inhibitors or receptor ligands involved in\nthese diseases. This review emphasizes the rationale behind the design of new drug candidates, and\nparticular attention is paid to the search for new leads over the last 10 years. QSAR and docking\nstudies are discussed, as well as new technologies applied for the research in this field. The\nmanuscripts discussed in this review have been collected from multiple electronic databases, including\nPubmed, SciFinder, and Mendeley.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026621666211011101429","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T05:31:52Z","timestamp":1634016712000},"page":"2245-2257","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Computer-aided Design of Coumarins for Neurodegenerative Diseases: Trends of the Last Decade"],"prefix":"10.2174","volume":"21","author":[{"given":"Estela Guardado","family":"Yordi","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"given":"Lourdes","family":"Santana","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007Porto, Portugal"}]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007Porto, Portugal"}]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007Porto, Portugal"}]},{"given":"Maria J.","family":"Matos","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007Porto, Portugal"}]}],"member":"965","container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/197138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/197138\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/197138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T16:53:17Z","timestamp":1637686397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/197138\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":0,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1568026621666211011101429","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2021-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}