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In addition, these biological modifications\nlead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative\ndisorders, and sleep disturbances, among others that affect activities of daily life.\nDemographic projections have demonstrated that aging will increase its worldwide rate in the coming\nyears. The research on chronic diseases of the elderly is important to gain insights into this\ngrowing global burden. Novel therapeutic approaches aimed for treatment of age-related pathologies\nhave included the endocannabinoid system as an effective tool since this biological system\nshows beneficial effects in preclinical models. However, and despite these advances, little has been\naddressed in the arena of the endocannabinoid system as an option for treating sleep disorders in\naging since experimental evidence suggests that some elements of the endocannabinoid system\nmodulate the sleep-wake cycle. This article addresses this less-studied field, focusing on the likely\nperspective of the implication of the endocannabinoid system in the regulation of sleep problems\nreported in the aged. We conclude that beneficial effects regarding the putative efficacy of the endocannabinoid\nsystem as therapeutic tools in aging is either inconclusive or still missing.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570159x17666190801155922","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T10:45:37Z","timestamp":1564656337000},"page":"97-108","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Endocannabinoid System May Modulate Sleep Disorders in Aging"],"prefix":"10.2174","volume":"18","author":[{"given":"Eric","family":"Murillo-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan, Mexico"}]},{"given":"Henning","family":"Budde","sequence":"additional","affiliation":[{"name":"Faculty of Human Sciences, Medical School Hamburg, Hamburg, Germany"}]},{"given":"Andr\u00e9 Barciela","family":"Veras","sequence":"additional","affiliation":[{"name":"Dom Bosco Catholic University, Campo Grande, Mato Grosso do Sul, Brazil"}]},{"given":"Nuno Barbosa","family":"Rocha","sequence":"additional","affiliation":[{"name":"School of Health, Polytechnic Institute of Porto, Porto, Portugal"}]},{"given":"Diogo","family":"Telles-Correia","sequence":"additional","affiliation":[{"name":"University of Lisbon, Faculty of Medicine, Lisbon, Portugal"}]},{"given":"Diogo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Sport Science School of Rio Maior-Polytechnic Institute of Santarem, Rio Maior, Portugal"}]},{"given":"Luis","family":"Cid","sequence":"additional","affiliation":[{"name":"Sport Science School of Rio Maior-Polytechnic Institute of Santarem, Rio Maior, Portugal"}]},{"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan"}]},{"given":"S\u00e9rgio","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Activity Neuroscience, Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University, Niteroi, Brazil"}]},{"given":"Pablo","family":"Torterolo","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiologia del Sueno, Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay"}]}],"member":"965","reference":[{"key":"ref=1","year":"2011","unstructured":"World Health Organization. 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