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However, the atherosclerotic process in uninfected\nchildren exposed in utero to the virus and antiretroviral therapy is less clear.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>To determine the potential cardiovascular risk associated to this in utero milieu exposition.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>A total of 115 individuals were studied (77 in the sample group and 38 in\nthe controls). Eighteen analytical mediators involved in the atherogenic pathways (metabolic dysregulation,\ninflammation, and prothrombotic state) were analyzed. The carotid intima-media thickness,\nwhich is a subclinical marker of atherosclerosis, was also measured.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>No significant statistical differences were identified between the sample and control\ngroups, either in the biochemical or the echographic markers.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In utero exposure to the HIV virus and antiretroviral therapy in uninfected children\nand adolescents is not correlated to accelerated atherosclerosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570162x18999201118155026","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T04:16:37Z","timestamp":1605845797000},"page":"216-224","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atherosclerotic Process in Seroreverter Children and Adolescents Exposed to Fetal Antiretroviral Therapy"],"prefix":"10.2174","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-3331","authenticated-orcid":true,"given":"Paula","family":"Martins","sequence":"first","affiliation":[{"name":"Paediatric Cardiology Service, Paediatric Hospital, Coimbra Hospital and Universitary Centre, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6864-9995","authenticated-orcid":true,"given":"Ant\u00f3nio","family":"Pires","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Service, Paediatric Hospital, Coimbra Hospital and Universitary Centre, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-6774","authenticated-orcid":true,"given":"Jos\u00e9 Luis","family":"Santos","sequence":"additional","affiliation":[{"name":"CMUC, Department of Mathematics, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-2977","authenticated-orcid":true,"given":"Cristina","family":"Sena","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Researh (iCBR) - Faculty of Medicine - University of Coimbra, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8378-0895","authenticated-orcid":true,"given":"Raquel","family":"Sei\u00e7a","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Researh (iCBR) - Faculty of Medicine - University of Coimbra, Coimbra, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"S213","DOI":"10.1542\/peds.2009-2107C","volume":"128","year":"2011","unstructured":"Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. 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