{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:34:39Z","timestamp":1773840879133,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["COS"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>In medical applications such as drug delivery, gene transfection and imaging the formation of systems with well-defined sizes\nand shapes are of significant interest. For this reason the design of dendrimers with modulated size, shape, branching length\/density, and\ntheir surface functionality, clearly distinguishes these structures as unique and optimum carriers for medical applications. The bioactive\nagents may be encapsulated into the interior of the dendrimers or chemically attached\/physically adsorbed onto the dendrimer surface,\nwith the option of tailoring the carrier to the specific needs of the active material and its therapeutic applications. In this regard one area\nwith growing attention is photodynamic therapy (PDT) where a photosensitizer combined with light and molecular oxygen can easily\ncause irreversible damage to the target tissue. Nevertheless most of the photosensitizers have solubility issues when attempts are made to\ndissolve them in aqueous environments, hampering in most cases their medical applicability. Currently, investigations are running towards\nthe combination of these photosensitizers with dendrimers increasing their organization, solubility and specificity to the target tissues.\nIn this communication we review the latest advancements in the synthesis of porphyrin and phthalocyanine dendrimer architectures,\nregarding their utility as biomedical agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/15701794113106660089","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T14:25:24Z","timestamp":1398003924000},"page":"110-126","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Porphyrins and Phthalocyanines Decorated with Dendrimers: Synthesis and Biomedical Applications"],"prefix":"10.2174","volume":"11","author":[{"given":"Fl\u00e1vio","family":"Figueira","sequence":"first","affiliation":[]},{"given":"Patr\u00edcia M.R.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Sandrina","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 A.S.","family":"Cavaleiro","sequence":"additional","affiliation":[]},{"given":"Joao P.C.","family":"Tome","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal and Department of Organic Chemistry, Gent University, B-9000, Gent, Belgium.,Belgium"}]}],"member":"965","container-title":["Current Organic Synthesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/15701794113106660089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/117319\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/15701794113106660089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:45:16Z","timestamp":1761669916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/117319\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/15701794113106660089","relation":{},"ISSN":["1570-1794"],"issn-type":[{"value":"1570-1794","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}