{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T11:51:08Z","timestamp":1721303468566},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["AIA"],"published-print":{"date-parts":[[2018,8,3]]},"abstract":"<jats:sec>\n<jats:title \/>\n<jats:p>Background: Fascioliasis is a neglected tropical disease that affects poor people from poor\nand developing countries. In the world, it has been estimated that at least 2.6 million people are affected\nwith this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis,\nalso liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis\ncaused by F. hepatica has not been associated with cancer to date. There are not any known causative\nassociations between this parasite and liver cancer (cholangiocarcinoma).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title \/>\n<jats:p>\nMethods: Chine Hamster Ovary (CHO) cells were treated with F. haepatica extracts and cell proliferation\nwas assessed by using the indirect method for estimating cell number based on the mitochondrial\nactivity with MTS cell proliferation reagent. We observed unexpected death of these cells when treated\nwith F. haepatica extracts.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title \/>\n<jats:p>\nResults and Conclusion: We now hypothesize that this parasite could be used as a medically-important\ntrematode pathogen in cancer therapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570180815666180531102555","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T06:31:16Z","timestamp":1527834676000},"page":"144-146","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells"],"prefix":"10.2174","volume":"16","author":[{"given":"Stephanie","family":"Ferreira","sequence":"first","affiliation":[{"name":"Escola Superior de Sa\u00fade, Instituto Polit\u00e9cnico do Porto, Porto, Portugal"}]},{"given":"Ruben","family":"Fernandes","sequence":"additional","affiliation":[{"name":"I3S, Instituto de Investigacao e Inovacao da Universidade do Porto, Porto, Portugal"}]},{"given":"Monica","family":"C. Botelho","sequence":"additional","affiliation":[{"name":"I3S, Instituto de Investigacao e Inovacao da Universidade do Porto, Porto, Portugal"}]}],"member":"965","container-title":["Anti-Infective Agents"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/162611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T07:01:03Z","timestamp":1587538863000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/162611\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1570180815666180531102555","relation":{},"ISSN":["2211-3525"],"issn-type":[{"value":"2211-3525","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2017-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}