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Attributes such as low-cost synthetic procedures, easy accessibility of reagents, and a broad spectrum of biological activities made sulfonamides and derivatives excellent candidates for synthesizing chemical libraries with structural diversity. Sulfonamide-based drugs are most of the sulfur-containing drugs approved by the United States Food and Drug Administration (FDA). Although sulfonamide derivatives have been extensively exploited as antibacterial agents, their therapeutic potential as antioxidants is relatively underexplored despite the prevalence of oxidative stress-mediated diseases and the urgent need for new and more effective antioxidant drugs. Some sulfonamide derivatives were shown to activate the nuclear factor erythroid 2-related factor 2 (Nrf2), the main regulator of the endogenous antioxidant response, a critical process used by cells in response to oxidative stress. The antioxidant role of sulfonamides and derivatives as Nrf2 activators is also reviewed. The antioxidant mechanism of action of sulfonamides has not been fully clarified, but as they have antioxidant properties, it is a subject worthy of in-depth study. The present review is focused on sulfonamides and derivatives as potential antioxidants along the period 2013-2021 and intends to stimulate research in the area.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1570193x19666220411134006","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T07:01:32Z","timestamp":1649746892000},"page":"190-209","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Sulfonamide a Valid Scaffold for Antioxidant Drug Development"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-4586","authenticated-orcid":true,"given":"Melford Chuka","family":"Egbujor","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences, Rhema University Nigeria, Aba, Abia State, Nigeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-231X","authenticated-orcid":true,"given":"Jorge","family":"Garrido","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemical Engineering, School of Engineering (ISEP), Polytechnic of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":true,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-8706","authenticated-orcid":true,"given":"Luciano","family":"Saso","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cVittorio Erspamer,\u201d Sapienza University of Rome, Rome, Italy"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1021\/jm1013693","volume":"54","author":"Meanwell N.A.","year":"2011","unstructured":"Meanwell N.A.; Synopsis of some recent tactical application of bioisosteres in drug design. 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