{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:16:15Z","timestamp":1777364175147,"version":"3.51.4"},"reference-count":69,"publisher":"Bentham Science Publishers Ltd.","issue":"1","funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation","doi-asserted-by":"publisher","award":["UID\/AGR\/04033\/2019"],"award-info":[{"award-number":["UID\/AGR\/04033\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CBC"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Abstract:<\/jats:title><jats:p>Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increase drug bioavailability and thereby improve the therapeutic outcome. The main reasons for the development of modified drug delivery systems for animal use are the need of reducing the animal stress caused by its handling and administration of the drug and of reducing the cost in financial and chronological terms. This review discusses the most common delivery systems used in veterinary, and the difficulties encountered in innovating therapeutic options in the field.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1573407218666220404110837","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T06:51:51Z","timestamp":1649141511000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Modified Drug Delivery Systems for Veterinary Use: Pharmaceutical Development and Applications"],"prefix":"10.2174","volume":"19","author":[{"given":"Eliana B.","family":"Souto","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua Jorge de Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"REQUIMTE\/UCIBIO, Faculty of Pharmacy of University of Porto, Rua Jorge de Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Antonello","family":"Santini","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy"}]},{"given":"Catarina I.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, 4200-150 Porto, Portugal"}]},{"given":"Iara","family":"Baldim","sequence":"additional","affiliation":[{"name":"CEB \u2013 Centre of Biological Engineering, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal"}]},{"given":"Joana R.","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua Jorge de Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Ana R.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"given":"Priscila G.","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Rua C\u00e2ndido Portinari, 200, Campinas, Sao Paulo, Zip Code 13083-871, Brazil"}]},{"given":"Tatiana","family":"Andreani","sequence":"additional","affiliation":[{"name":"Departamento de Biologia e Ambiente, Universidade de Tr\u00e1s-os-Montes e Alto Douro (UTAD), P.O. Box 1013; 5001-801 Vila Real, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o e de Tecnologias Agro-Ambientais e Biol\u00f3gicas (CITAB-UTAD), Vila Real, Portugal"}]},{"given":"Isabel R.","family":"Dias","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Veterin\u00e1rias, Universidade de Tr\u00e1s-os Montes e Alto Douro, Vila Real, Portugal"}]},{"given":"Alessandra","family":"Durazzo","sequence":"additional","affiliation":[{"name":"CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"}]},{"given":"Massimo","family":"Lucarini","sequence":"additional","affiliation":[{"name":"CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"}]},{"given":"Atanas G.","family":"Atanasov","sequence":"additional","affiliation":[{"name":"The Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrz\u0119biec, 05-552 Magdalenka, Poland"},{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev str., 1113 Sofia, Bulgaria"},{"name":"Department of Pharmacognosy, University of Vienna, Vienna, Austria"}]},{"given":"Am\u00e9lia M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Biologia e Ambiente, Universidade de Tr\u00e1s-os-Montes e Alto Douro (UTAD), P.O. Box 1013; 5001-801 Vila Real, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o e de Tecnologias Agro-Ambientais e Biol\u00f3gicas (CITAB-UTAD), Vila Real, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/2211738508666200613214548","volume":"9","author":"da Silva C.F.","year":"2021","unstructured":"da Silva C.F.; Almeida T.; de Melo B.R.; Cardoso J.C.; Morsink M.; Souto E.B.; Severino P.; New trends in drug delivery systems for veterinary applications. Pharm Nanotechnol 2021,9(1),15-25","journal-title":"Pharm Nanotechnol"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/jac\/dkn213","volume":"62","author":"Moulin G.","year":"2008","unstructured":"Moulin G.; Cavali&#xE9; P.; Pellanne I.; Chevance A.; Laval A.; Millemann Y.; Colin P.; Chauvin C.; A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005. J Antimicrob Chemother 2008,62(3),617-625","journal-title":"J Antimicrob Chemother"},{"key":"ref=3","first-page":"10","volume":"1","author":"Ramteke K.H.","year":"2014","unstructured":"Ramteke K.H.; Joshi S.A.; Dighe P.A.; Kharat A.R.; Veterinary pharmaceutical dosage forms: A technical note. Austin Therapeutics 2014,1(1),10","journal-title":"Austin Therapeutics"},{"key":"ref=4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/978-1-4939-1998-7_2","author":"Holowka E.P.","year":"2014","unstructured":"Holowka E.P.; Bhatia S.K.; In: Drug Delivery: Materials Design and Clinical Perspective 2014,7-62","journal-title":"In: Drug Delivery: Materials Design and Clinical Perspective"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.2344\/0003-3006-58.4.166","volume":"58","author":"Becker D.E.","year":"2011","unstructured":"Becker D.E.; Pharmacokinetic considerations for moderate and deep sedation. Anesth Prog 2011,58(4),166-172","journal-title":"Anesth Prog"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/j.addr.2004.02.008","volume":"56","author":"Winzenburg G.","year":"2004","unstructured":"Winzenburg G.; Schmidt C.; Fuchs S.; Kissel T.; Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems. Adv Drug Deliv Rev 2004,56(10),1453-1466","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=7","first-page":"1","author":"Niazi S.K.","year":"2019","unstructured":"Niazi S.K.; Handbook of pharmaceutical manufacturing formulations: Sterile products 2019,1-452","journal-title":"Handbook of pharmaceutical manufacturing formulations: Sterile products"},{"key":"ref=8","author":"U.K. Essays","year":"2013","unstructured":"U.K. Essays; The advantages and limitations of oral route formulations biology essay Available from: (Accessed September 5, 2021).2013","journal-title":"The advantages and limitations of oral route formulations biology essay"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/cphy.c110054","volume":"3","author":"Karasov W.H.","year":"2013","unstructured":"Karasov W.H.; Douglas A.E.; Comparative digestive physiology. Compr Physiol 2013,3(2),741-783","journal-title":"Compr Physiol"},{"key":"ref=10","doi-asserted-by":"publisher","DOI":"10.1201\/b15115","author":"Augsburger L.L.","year":"2016","unstructured":"Augsburger L.L.; Hoag S.W.; Pharmaceutical dosage forms-tablets 2016","journal-title":"Pharmaceutical dosage forms-tablets"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1046\/j.1365-2796.2001.00758.x","volume":"249","author":"Urquhart J.","year":"2001","unstructured":"Urquhart J.; Controlled drug delivery: Therapeutic and pharmacological aspects. J Intern Med 2001,249(S741),75-94","journal-title":"J Intern Med"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.addr.2004.02.011","volume":"56","author":"Vandamme T.F.","year":"2004","unstructured":"Vandamme T.F.; Ellis K.J.; Issues and challenges in developing ruminal drug delivery systems. Adv Drug Deliv Rev 2004,56(10),1415-1436","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/S1461-5347(00)00276-5","volume":"3","author":"Rothen-Weinhold A.","year":"2000","unstructured":"Rothen-Weinhold A.; Gurny R.; Dahn M.; Formulation and technology aspects of conrolled drug delivery in animals. Pharm Sci Technol Today 2000,3(7),222-231","journal-title":"Pharm Sci Technol Today"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.addr.2004.02.005","volume":"56","author":"Medlicott N.J.","year":"2004","unstructured":"Medlicott N.J.; Waldron N.A.; Foster T.P.; Sustained release veterinary parenteral products. Adv Drug Deliv Rev 2004,56(10),1345-1365","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S1359-6446(02)02362-0","volume":"7","author":"Rathbone M.J.","year":"2002","unstructured":"Rathbone M.J.; Martinez M.N.; Modified release drug delivery in veterinary medicine. Drug Discov Today 2002,7(15),823-829","journal-title":"Drug Discov Today"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"358","DOI":"10.14202\/vetworld.2017.358-362","volume":"10","author":"Refaai W.","year":"2017","unstructured":"Refaai W.; Gad M.; Mahmmod Y.; Association of claw disorders with subclinical intramammary infections in Egyptian dairy cows. Vet World 2017,10(3),358-362","journal-title":"Vet World"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0168-3659(88)90094-6","volume":"8","author":"Desmond B.J.","year":"1988","unstructured":"Desmond B.J.; Veterinary drug formulations for animal health care: An overview. J Control Release 1988,8(1),5-13","journal-title":"J Control Release"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.3168\/jds.2008-1497","volume":"92","author":"Bradley A.J.","year":"2009","unstructured":"Bradley A.J.; Green M.J.; Factors affecting cure when treating bovine clinical mastitis with cephalosporin-based intra mammary preparations. J Dairy Sci 2009,92(5),1941-1953","journal-title":"J Dairy Sci"},{"key":"ref=19","first-page":"567","volume":"47","author":"Olde Riekerink R.G.","year":"2006","unstructured":"Olde Riekerink R.G.; Barkema H.W.; Veenstra S.; Poole D.E.; Dingwell R.T.; Keefe G.P.; Prevalence of contagious mastitis pathogens in bulk tank milk in Prince Edward Island. Can Vet J 2006,47(6),567-572","journal-title":"Can Vet J"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.18805\/ajdfr.v35i4.6624","volume":"35","author":"Jadhav P.","year":"2016","unstructured":"Jadhav P.; Tarate S.; Bhuvana M.; Das D.; Shome B.; Somatic cell count as a monitoring system for hygienic milk production in India: A review. J Dairy Foods Home Sci 2016,35(4),270-277","journal-title":"J Dairy Foods Home Sci"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"6243","DOI":"10.3168\/jds.2011-4645","volume":"94","author":"Norman H.D.","year":"2011","unstructured":"Norman H.D.; Lombard J.E.; Wright J.R.; Kopral C.A.; Rodriguez J.M.; Miller R.H.; Consequence of alternative standards for bulk tank somatic cell count of dairy herds in the United States. J Dairy Sci 2011,94(12),6243-6256","journal-title":"J Dairy Sci"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.3168\/jds.S0022-0302(00)75175-7","volume":"83","author":"Norman H.D.","year":"2000","unstructured":"Norman H.D.; Miller R.H.; Wright J.R.; Wiggans G.R.; Herd and state means for somatic cell count from dairy herd improvement. J Dairy Sci 2000,83(12),2782-2788","journal-title":"J Dairy Sci"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3168\/jds.2016-11465","volume":"100","author":"Taponen S.","year":"2017","unstructured":"Taponen S.; Liski E.; Heikkil&#xE4; A.M.; Py&#xF6;r&#xE4;l&#xE4; S.; Factors associated with intramammary infection in dairy cows caused by coagulase-negative staphylococci, Staphylococcus aureus, Streptococcus uberis, Streptococcus dysgalactiae, Corynebacterium bovis, or Escherichia coli. J Dairy Sci 2017,100(1),493-503","journal-title":"J Dairy Sci"},{"key":"ref=24","volume":"74","author":"Gomes F.","year":"2016","unstructured":"Gomes F.; Saavedra M.J.; Henriques M.; Bovine mastitis disease\/pathogenicity: Evidence of the potential role of microbial biofilms. Pathog Dis 2016,74(3)","journal-title":"Pathog Dis"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1186\/2046-0481-62-S4-S40","volume":"62","author":"Py&#xF6;r&#xE4;l&#xE4; S.","year":"2009","unstructured":"Py&#xF6;r&#xE4;l&#xE4; S.; Treatment of mastitis during lactation. Ir Vet J 2009,62(S4)(Suppl. 4),S40-S44","journal-title":"Ir Vet J"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/rda.13032","volume":"52","author":"Kr&#xF6;mker V.","year":"2017","unstructured":"Kr&#xF6;mker V.; Leimbach S.; Mastitis treatment-reduction in antibiotic usage in dairy cows. Reprod Domest Anim 2017,52(Suppl. 3),21-29","journal-title":"Reprod Domest Anim"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2174\/156720109787048186","volume":"6","author":"Chaisri W.","year":"2009","unstructured":"Chaisri W.; Hennink W.E.; Okonogi S.; Preparation and characterization of cephalexin loaded PLGA microspheres. Curr Drug Deliv 2009,6(1),69-75","journal-title":"Curr Drug Deliv"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1208\/s12249-010-9453-5","volume":"11","author":"Chaisri W.","year":"2010","unstructured":"Chaisri W.; Hennink W.E.; Ampasavate C.; Okonogi S.; Cephalexin microspheres for dairy mastitis: Effect of preparation method and surfactant type on physicochemical properties of the microspheres. AAPS PharmSciTech 2010,11(2),945-951","journal-title":"AAPS PharmSciTech"},{"key":"ref=29","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.56026\/imu.6.Suppl1.S118","volume":"6","author":"Rathbone M.J.","year":"2012","unstructured":"Rathbone M.J.; Delivering drugs to farmed animals using controlled release science and technology. IeJSME 2012,6(Suppl. 1),S118-S128","journal-title":"IeJSME"},{"key":"ref=30","first-page":"31","volume":"23","author":"Helbling I.M.","year":"2017","unstructured":"Helbling I.M.; Luna J.A.; Progesterone administration in planned reproduction of cattle. Int J Med Biol Front 2017,23(1),31-71","journal-title":"Int J Med Biol Front"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.theriogenology.2015.03.018","volume":"84","author":"Swelum A.A.","year":"2015","unstructured":"Swelum A.A.; Alowaimer A.N.; Abouheif M.A.; Use of fluorogestone acetate sponges or controlled internal drug release for estrus synchronization in ewes: Effects of hormonal profiles and reproductive performance. Theriogenology 2015,84(4),498-503","journal-title":"Theriogenology"},{"key":"ref=32","first-page":"43","volume":"72","author":"Walsh R.B.","year":"2008","unstructured":"Walsh R.B.; LeBlanc S.J.; Vernooy E.; Leslie K.E.; Safety of a progesterone-releasing intravaginal device as assessed from vaginal mucosal integrity and indicators of systemic inflammation in postpartum dairy cows. Can J Vet Res 2008,72(1),43-49","journal-title":"Can J Vet Res"},{"key":"ref=33","first-page":"1617","volume":"1","author":"Kurup K.R.","year":"2017","unstructured":"Kurup K.R.; Parikh P.V.; Mahla J.K.; Ratnu D.A.; Optimized ophthalmic: Advances in the treatment of ocular diseases in animals. Biomed J Sci Tech Res 2017,1(6),1617-1620","journal-title":"Biomed J Sci Tech Res"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0169-409X(97)00088-4","volume":"28","author":"Gurny R.","year":"1997","unstructured":"Gurny R.; Kaltsatos V.; Deshpande A.A.; Zignani M.; Percicot C.; Baeyens V.; Ocular drug delivery in veterinary medicine. Adv Drug Deliv Rev 1997,28(3),335-361","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0168-3659(94)00096-D","volume":"33","author":"Gurtler F.","year":"1995","unstructured":"Gurtler F.; Kaltsatos V.; Boisram&#xE9; B.; Gurny R.; Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: Optimization and clinical investigation. J Control Release 1995,33(2),231-236","journal-title":"J Control Release"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3390\/pharmaceutics12060570","volume":"12","author":"Mazet R.","year":"2020","unstructured":"Mazet R.; Yam&#xE9;ogo J.B.G.; Wouessidjewe D.; Choisnard L.; G&#xE8;ze A.; Recent advances in the design of topical ophthalmic delivery systems in the treatment of ocular surface inflammation and their biopharmaceutical evaluation. Pharmaceutics 2020,12(6),570","journal-title":"Pharmaceutics"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0169-409X(01)00158-2","volume":"50","author":"Magnusson B.M.","year":"2001","unstructured":"Magnusson B.M.; Walters K.A.; Roberts M.S.; Veterinary drug delivery: Potential for skin penetration enhancement. Adv Drug Deliv Rev 2001,50(3),205-227","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1053\/tvjl.2000.0549","volume":"161","author":"Taylor M.A.","year":"2001","unstructured":"Taylor M.A.; Recent developments in ectoparasiticides. Vet J 2001,161(3),253-268","journal-title":"Vet J"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0169-409X(01)00157-0","volume":"50","author":"Riviere J.E.","year":"2001","unstructured":"Riviere J.E.; Papich M.G.; Potential and problems of developing transdermal patches for veterinary applications. Adv Drug Deliv Rev 2001,50(3),175-203","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.tvjl.2005.09.006","volume":"172","author":"Mills P.C.","year":"2006","unstructured":"Mills P.C.; Cross S.E.; Transdermal drug delivery: Basic principles for the veterinarian. Vet J 2006,172(2),218-233","journal-title":"Vet J"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"E281","DOI":"10.1208\/aapsj070229","volume":"7","author":"Papich M.G.","year":"2005","unstructured":"Papich M.G.; Drug compounding for veterinary patients. AAPS J 2005,7(2),E281-E287","journal-title":"AAPS J"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0169-409X(02)00074-1","volume":"54","author":"Ahmed I.","year":"2002","unstructured":"Ahmed I.; Kasraian K.; Pharmaceutical challenges in veterinary product development. Adv Drug Deliv Rev 2002,54(6),871-882","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=43","author":"Gon&#xE7;alves C.S.","unstructured":"Gon&#xE7;alves C.S.; Polli S.A.L.; Martins dos Santos A.; Fonseca-Santos B.; Duque R.W.; Daflon M.P.; Chorilli M.; Oliveira Villanova J.C.; Polymeric-based drug delivery systems for veterinary use: State of the art. 604, 120756."},{"key":"ref=44","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1939-1676.2003.tb02491.x","volume":"17","author":"Wyse C.A.","year":"2003","unstructured":"Wyse C.A.; McLellan J.; Dickie A.M.; Sutton D.G.; Preston T.; Yam P.S.; A review of methods for assessment of the rate of gastric emptying in the dog and cat: 1898-2002. J Vet Intern Med 2003,17(5),609-621","journal-title":"J Vet Intern Med"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.addr.2004.02.013","volume":"56","author":"Sutton S.C.","year":"2004","unstructured":"Sutton S.C.; Companion animal physiology and dosage form performance. Adv Drug Deliv Rev 2004,56(10),1383-1398","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.2042-3306.1995.tb04066.x","volume":"27","author":"Gratzek A.T.","year":"1995","unstructured":"Gratzek A.T.; Kaswan R.L.; Martin C.L.; Champagne E.S.; White S.L.; Ophthalmic cyclosporine in equine keratitis and keratouveitis: 11 cases. Equine Vet J 1995,27(5),327-333","journal-title":"Equine Vet J"},{"key":"ref=47","first-page":"157","volume":"9","author":"Boda C.","year":"2011","unstructured":"Boda C.; Li&#xE8;ge P.; R&#xE8;me C.A.; Evaluation of owner compliance with topical treatment of acute otitis externa in dogs: A comparative study of two auricular formulations. Int J Appl Res Vet Med 2011,9(2),157","journal-title":"Int J Appl Res Vet Med"},{"key":"ref=48","first-page":"128, 3- 28","author":"Sharma T","year":"2018","unstructured":"Sharma T; Sanjay ST; Zhoua W; Doua M; Recent advances of controlled drug delivery using microfuidic platforms 2018,128, 3- 28","journal-title":"Recent advances of controlled drug delivery using microfuidic platforms"},{"key":"ref=49","first-page":"166","volume":"4","author":"Dawit G.","year":"2013","unstructured":"Dawit G.; Girma Z.; Simenew K.; A review on biology, epidemiology and public health significance of leishmaniasis. J Bacteriol Parasitol 2013,4(2),166","journal-title":"J Bacteriol Parasitol"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0001-706X(99)00034-0","volume":"73","author":"Armson A.","year":"1999","unstructured":"Armson A.; Kamau S.W.; Grimm F.; Reynoldson J.A.; Best W.M.; MacDonald L.M.; Thompson R.C.; A comparison of the effects of a benzimidazole and the dinitroanilines against Leishmania infantum. Acta Trop 1999,73(3),303-311","journal-title":"Acta Trop"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1439-0442.2006.00869.x","volume":"53","author":"Jo&#xE3;o A.","year":"2006","unstructured":"Jo&#xE3;o A.; Pereira M.A.; Cortes S.; Santos-Gomes G.M.; Canine leishmaniasis chemotherapy: Dog\u2019s clinical condition and risk of Leishmania transmission. J Vet Med A Physiol Pathol Clin Med 2006,53(10),540-545","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.tvjl.2007.07.016","volume":"178","author":"Marques C.","year":"2008","unstructured":"Marques C.; Carvalheiro M.; Pereira M.A.; Jorge J.; Cruz M.E.M.; Santos-Gomes G.M.; Efficacy of the liposome trifluralin in the treatment of experimental canine leishmaniosis. Vet J 2008,178(1),133-137","journal-title":"Vet J"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.livprodsci.2004.07.004","volume":"90","author":"Nardone A.","year":"2004","unstructured":"Nardone A.; Zervas G.; Ronchi B.; Sustainability of small ruminant organic systems of production. Livest Prod Sci 2004,90(1),27-39","journal-title":"Livest Prod Sci"},{"key":"ref=54","first-page":"39","volume":"2","author":"Rafiei Tabatabaei R.","year":"2003","unstructured":"Rafiei Tabatabaei R.; Nasirian A.; Isolation, identification and antimicrobial resistance patterns of E. coli isolated from chicken flocks. Iranian J. Pharmaco. Ther 2003,2(2),39-0","journal-title":"Ther"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1021\/ja039822x","volume":"126","author":"Rangin M.","year":"2004","unstructured":"Rangin M.; Basu A.; Lipopolysaccharide identification with functionalized polydiacetylene liposome sensors. J Am Chem Soc 2004,126(16),5038-5039","journal-title":"J Am Chem Soc"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1099\/jmm.0.014720-0","volume":"59","author":"Dissanayake D.R.A.","year":"2010","unstructured":"Dissanayake D.R.A.; Wijewardana T.G.; Gunawardena G.A.; Poxton I.R.; Potential use of a liposome-encapsulated mixture of lipopolysaccharide core types (R1, R2, R3 and R4) of Escherichia coli in controlling colisepticaemia in chickens. J Med Microbiol 2010,59(Pt 1),100-107","journal-title":"J Med Microbiol"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2147\/IDR.S55778","volume":"8","author":"Economou V.","year":"2015","unstructured":"Economou V.; Gousia P.; Agriculture and food animals as a source of antimicrobial-resistant bacteria. Infect Drug Resist 2015,8,49-61","journal-title":"Infect Drug Resist"},{"key":"ref=58","first-page":"1","author":"Rathbone M.J.","year":"2000","unstructured":"Rathbone M.J.; Gurny R.; Controlled Release Veterinary Drug Delivery: Biological and pharmaceutical considerations 2000,1-375","journal-title":"Controlled Release Veterinary Drug Delivery: Biological and pharmaceutical considerations"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/B978-044482992-4\/50025-3","author":"Rathbone M.J.","year":"2000","unstructured":"Rathbone M.J.; Burke C.R.; Ogle C.R.; Bunt C.R.; Burggraaf S.; Macmillan K.L.; Design and development of controlled release intravaginal veterinary drug delivery systems Controlled Release Veterinary Drug Delivery 2000,173-200","journal-title":"Design and development of controlled release intravaginal veterinary drug delivery systems Controlled Release Veterinary Drug Delivery"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.rinphs.2011.11.002","volume":"1","author":"Gardyne S.J.","year":"2011","unstructured":"Gardyne S.J.; Mucalo M.R.; Rathbone M.J.; The application of co-melt-extruded poly(&#x3B5;-caprolactone) as a controlled release drug delivery device when combined with novel bioactive drug candidates: Membrane permeation and Hanson dissolution studies. Results Pharma Sci 2011,1(1),80-87","journal-title":"Results Pharma Sci"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v15.i4.10","volume":"15","author":"Rathbone M.J.","year":"1998","unstructured":"Rathbone M.J.; Macmillan K.L.; J&#xF6;chle W.; Boland M.P.; Inskeep E.K.; Controlled-release products for the control of the estrus cycle in cattle, sheep, goats, deer, pigs, and horses. Crit Rev Ther Drug Carrier Syst 1998,15(4),285-379","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0020-7519(01)00361-7","volume":"32","author":"Irwin P.J.","year":"2002","unstructured":"Irwin P.J.; Companion animal parasitology: A clinical perspective. Int J Parasitol 2002,32(5),581-593","journal-title":"Int J Parasitol"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0169-409X(99)00011-3","volume":"38","author":"Witchey-Lakshmanan L.C.","year":"1999","unstructured":"Witchey-Lakshmanan L.C.; Long-acting control of ectoparasites: A review of collar technologies for companion animals. Adv Drug Deliv Rev 1999,38(2),113-122","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=64","author":"Huet A.-M.","year":"2005","unstructured":"Huet A.-M.; Julia B.; Etchegaray J.-P.; Weil A.; Jeannin P.; Spot-on formulations for combating parasites. US20030050327A1, 2005"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.2527\/jas.2008-1670","volume":"87","author":"Carn&#xE9; S.","year":"2009","unstructured":"Carn&#xE9; S.; Gipson T.A.; Rovai M.; Merkel R.C.; Caja G.; Extended field test on the use of visual ear tags and electronic boluses for the identification of different goat breeds in the United States. J Anim Sci 2009,87(7),2419-2427","journal-title":"J Anim Sci"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.3390\/app10051594","volume":"10","author":"Souto E.B.","year":"2020","unstructured":"Souto E.B.; Fernandes A.R.; Martins-Gomes C.; Coutinho T.E.; Durazzo A.; Lucarini M.; Souto S.B.; Silva A.M.; Santini A.; Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals. Appl Sci (Basel) 2020,10(5),1594","journal-title":"Appl Sci (Basel)"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.crbiot.2020.04.002","volume":"2","author":"Yeung A.W.K.","year":"2020","unstructured":"Yeung A.W.K.; Eliana B.; Souto E.B.; Durazzo A.; Lucarini M.; Novellino E.; Tewari D.; Wang D.; Atanasov A.G.; Antonello S.A.; Big impact of nanoparticles: Analysis of the most cited nanopharmaceuticals and nanonutraceuticals research. Curr Res Biotechnol 2020,2,53-63","journal-title":"Curr Res Biotechnol"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3390\/pharmaceutics12020146","volume":"12","author":"Souto E.B.","year":"2020","unstructured":"Souto E.B.; Silva G.F.; Dias-Ferreira J.; Zielinska A.; Ventura F.; Durazzo A.; Lucarini M.; Novellino E.; Santini A.; Nanopharmaceutics: Part I-Clinical Trials legislation and good manufacturing practices (GMP) of nanotherapeutics in the EU. Pharmaceutics 2020,12(2),146","journal-title":"Pharmaceutics"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/nano10030455","volume":"10","author":"Souto E.B.","year":"2020","unstructured":"Souto E.B.; Silva G.F.; Dias-Ferreira J.; Zielinska A.; Ventura F.; Durazzo A.; Lucarini M.; Novellino E.; Santini A.; Nanopharmaceutics: Part II-production scales and clinically compliant production methods. Nanomaterials (Basel) 2020,10(3),455","journal-title":"Nanomaterials (Basel)"}],"container-title":["Current Bioactive Compounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1573407218666220404110837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/203061\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1573407218666220404110837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:57:24Z","timestamp":1700413044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/203061\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573407218666220404110837","relation":{},"ISSN":["1573-4072"],"issn-type":[{"value":"1573-4072","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2021-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}