{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T21:29:02Z","timestamp":1763155742878,"version":"build-2065373602"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNANO"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Nanoparticles of lyotropic liquid crystals loaded with a new photosensitizer (a chlorin derivative) were developed for use in\nphotodynamic therapy (PDT). These systems were characterized by spectrofluorimetric, dynamic light scattering, and small angle X-ray\ndiffraction (SAXRD) analyses. In vitro and in vivo penetration studies in animal models were performed using animal model membranes.\nThe systems had a particle size of 161 \u00b1 4 nm and a polydispersity index of 0.175 \u00b1 0.027. Furthermore, SAXRD studies demonstrated\nthat the preparations remained in the liquid crystalline phase type hexagonal after drug loading. The encapsulation rate was higher than\n50%, and cell viability studies revealed that the nanodispersion is not harmful for L929 skin cells. In vitro and in vivo penetration studies\nconfirmed that the nanodispersion of hexagonal phase enabled a higher drug skin uptake compared to the control. Additionally, a fluorescence\nmicroscopy study demonstrated a higher biodistribution of the chlorin derivative in the skin layers of hairless mice compared to the\ncontrol. Taken together, the results show the potential of this nanodispersion for the delivery of the photosensitizer into the skin, which is\na crucial condition for successful topical PDT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1573413711309040003","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T16:53:34Z","timestamp":1374598414000},"page":"434-441","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Nanoparticles of Lyotropic Liquid Crystals: A Novel Strategy for the Topical Delivery of a Chlorin Derivative for Photodynamic Therapy of Skin Cancer"],"prefix":"10.2174","volume":"9","author":[{"given":"Raquel","family":"Petrilli","sequence":"first","affiliation":[]},{"given":"Fabiola S.G.","family":"Praca","sequence":"additional","affiliation":[]},{"given":"Aline Regina H.","family":"Carollo","sequence":"additional","affiliation":[]},{"given":"Wanessa S.G.","family":"Medina","sequence":"additional","affiliation":[]},{"given":"Kleber Thiago de","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Marcia C.A.","family":"Fantini","sequence":"additional","affiliation":[]},{"given":"Maria da Graca P.M.S.","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Jose A.S.","family":"Cavaleiro","sequence":"additional","affiliation":[]},{"given":"Osvaldo A.","family":"Serra","sequence":"additional","affiliation":[]},{"given":"Yassuko","family":"Iamamoto","sequence":"additional","affiliation":[]},{"given":"Maria Vitoria L.B.","family":"Bentley","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe, s\/n, CEP 14040-903, Ribeirao Preto, SP, Brazil.,Brazil"}]}],"member":"965","container-title":["Current Nanoscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1573413711309040003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/113103\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1573413711309040003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:16:33Z","timestamp":1761549393000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/113103\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573413711309040003","relation":{},"ISSN":["1573-4137"],"issn-type":[{"type":"print","value":"1573-4137"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}