{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:23:36Z","timestamp":1747207416991,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2021,4,29]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Rocuronium is a muscle relaxant with increased use due to its binding\nrelation with the reversal agent sugammadex. The purpose of this review entails the investigation of\nits use for the maintenance of Deep Neuromuscular Block (NMB) via continuous infusion.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Based on PRISMA systematic search guidelines, databases included PubMed, ISI Web of\nScience, Cochrane Library and Google Scholar. This comprehensive search addresses surgical patients\nunder deep muscle relaxation via continuous rocuronium infusion. The main indicators were\nthe rocuronium administration, NMB monitoring approaches and effects in order to maintain the\ndeep level of relaxation, as well as reversal time after a standard dose of sugammadex.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Despite the variance in approaches found in the literature, findings show the overall maintenance\nof deep NMB requires approximately 0.758 mg.kg<jats:sup>-1<\/jats:sup>h<jats:sup>-1<\/jats:sup> of rocuronium (according to the\nPTC target of 0-10, 0-5 and 1-2, mean estimates are 0.445, 0.65 and 0.833 mg.kg<jats:sup>-1<\/jats:sup>h<jats:sup>-1<\/jats:sup> respectively),\nsuggesting that a lower range and a smaller maximum of PTC response require higher amount of\nrocuronium for its maintenance. The standard dose of sugammadex (4 mg\/kg), administered at the\nend of the surgery takes longer [2.85 (1.17) min] than when they are administered after moderate\nNMB recovery [1.68 (0.47) min].<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Continuous infusion for deep NMB presents inherent advantages in terms of maintenance\nand stability of muscle relaxation. Monitoring and rocuronium administration approaches are\nfundamental and intrinsically connected to provide a stable and improved maintenance of deep\nNMB.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574884714666191120144331","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T13:44:47Z","timestamp":1574343887000},"page":"64-72","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systematic Review on Rocuronium Continuous Infusion for Deep Neuromuscular Blockade"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-8355","authenticated-orcid":true,"given":"Mafalda","family":"Couto","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Faculdade de Engenharia da Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-2828","authenticated-orcid":true,"given":"Jose G.","family":"Couto","sequence":"additional","affiliation":[{"name":"Radiography Department, Faculty of Health Sciences, University of Malta, Msida, MSD 2080, Malta"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-0994","authenticated-orcid":true,"given":"Catarina S.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Aberta, Department of Sciences and Technology, Delegation of Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-2250","authenticated-orcid":true,"given":"S\u00e9rgio","family":"Vide","sequence":"additional","affiliation":[{"name":"Centro de Investigacao Clinica em Anestesiologia, Servi\u00e7o de Anestesiologia, Centro Hospitalar e Universitario do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-4174","authenticated-orcid":true,"given":"Pedro","family":"Amorim","sequence":"additional","affiliation":[{"name":"Centro de Investigacao Clinica em Anestesiologia, Servi\u00e7o de Anestesiologia, Centro Hospitalar e Universitario do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-1879","authenticated-orcid":true,"given":"Joquim","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Faculdade de Engenharia da Universidade do Porto, Porto, Portugal"}]}],"member":"965","container-title":["Current Reviews in Clinical and Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/176879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/176879\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/176879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T18:59:46Z","timestamp":1621882786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/176879\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,4,29]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574884714666191120144331","relation":{},"ISSN":["2772-4328"],"issn-type":[{"type":"print","value":"2772-4328"}],"subject":[],"published":{"date-parts":[[2021,4,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}