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(ROS).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Using in vitro cell cultures, the influence of 2-amino-3-cyanoquinoxaline-1,4-dioxide (2A3CQNX), 3-\nmethyl-2-quinoxalinecarboxamide-1,4-dioxide (3M2QNXC) and 2-hydroxyphenazine-1,4-dioxide (2HF) was\nevaluated in metabolic activity, catalase activity, glutathione and 3-nitrotyrosine (3-NT) quantitation by HPLC\nin malignant melanocytes (B16-F10, MeWo) and brain tumor cells (GL-261 and BC3H1) submitted to radiotherapy\ntreatments (total dose of 6 Gy).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>2HF increased the levels of 3-NT in non-irradiated MeWo and glioma cell lines and decreased cell\nviability in these cell lines with and without irradiation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>Quinoxaline-1,4-dioxides derivatives modulate the oxidative status in malignant melanocytes and\nbrain tumor cell lines and exhibited a potential radiosensitizer in vitro action on the tested radioresistant cell\nlines.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871520619666191028091547","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T15:30:36Z","timestamp":1575300636000},"page":"111-120","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives"],"prefix":"10.2174","volume":"20","author":[{"given":"Liliana","family":"Silva","sequence":"first","affiliation":[{"name":"Centro de Investigacao em Saude Ambiental (CISA), Escola Superior de Saude do Porto, Politecnico do Porto, Porto, Portugal"}]},{"given":"Pedro","family":"Coelho","sequence":"additional","affiliation":[{"name":"Centro de Investigacao em Saude Ambiental (CISA), Escola Superior de Saude do Porto, Politecnico do Porto, Porto, 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