{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:02:21Z","timestamp":1773273741117,"version":"3.50.1"},"reference-count":59,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2019,1,3]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>The prevalence of thyroid dysfunction and autoimmunity in the Portuguese population has not yet been estimated. However, the national prevalence of the metabolic syndrome remains high. The association of thyroid pathology with cardiovascular risk has been addressed but is still unclear. Our study aimed to evaluate the prevalence of thyroid dysfunction and autoimmunity and to assess the associations of thyroid-stimulating hormone and thyroid hormones and antibodies with metabolic syndrome, its components, and other possible determinants in a national sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods:<\/jats:title><jats:p>The present study included a subsample of 486 randomly selected participants from a nationwide cross-sectional study sample of 4095 adults. A structured questionnaire was administered on past medical history and socio-demographic and behavioural characteristics. Blood pressure and anthropometric measurements were collected, and the serum lipid profile, glucose, insulin, hs- CRP, TSH, FT4, FT3 and thyroid antibodies were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In our sample, the prevalence of hypothyroidism, hyperthyroidism and undiagnosed dysfunction was 4.9%, 2.5% and 72.2%, respectively. Overall, the prevalence of positivity for the thyroid peroxidase and thyroglobulin antibodies was 11.9% and 15.0%, respectively. A positive association was found between free triiodothyronine and metabolic syndrome (OR: 2.019; 95% CI: 1.196, 3.410). Additionally, thyroid peroxidase antibodies had a negative association with metabolic syndrome (OR: 0.465; 95% CI: 0.236, 0.917) and its triglyceride component (OR: 0.321; 95% CI: 0.124, 0.836).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The prevalence of undiagnosed thyroid dysfunction and autoimmunity was high. Thyroid peroxidase antibodies were negatively associated with metabolic syndrome and its triglyceride component, whereas the free triiodothyronine level was positively associated with metabolic syndrome.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1871530318666180801125258","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T11:49:04Z","timestamp":1533124144000},"page":"75-83","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study"],"prefix":"10.2174","volume":"19","author":[{"given":"Lu\u00eds","family":"Raposo","sequence":"first","affiliation":[{"name":"EPIUnit - Instituto de Saude Publica, Universidade do Porto, Porto, Portugal"}]},{"given":"Sandra","family":"Martins","sequence":"additional","affiliation":[{"name":"EPIUnit - Instituto de Saude Publica, Universidade do Porto, Porto, Portugal"}]},{"given":"Daniela","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias da Saude Publica e Forenses e Educacao Medica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"Jo\u00e3o Tiago","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"EPIUnit - Instituto de Saude Publica, Universidade do Porto, Porto, Portugal"}]},{"given":"Ana Cristina","family":"Santos","sequence":"additional","affiliation":[{"name":"EPIUnit - Instituto de Saude Publica, Universidade do Porto, Porto, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2013-2409","volume":"99","author":"Garmendia M.A.","year":"2014","unstructured":"Garmendia MA, Santos PS, Guill\u00e9n-Grima F, Galofr\u00e9 JC. 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The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: A metaanalysis.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref=5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1871530311313010003","volume":"13","author":"Gencer B.","year":"2013","unstructured":"Gencer B, Collet TH, Virgini V, Auer R, Rodondi N. Subclinical thyroid dysfunction and cardiovascular outcomes among prospective cohort studies.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"ref=6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/oxfordjournals.eurheartj.a061550","volume":"5","author":"Aho K.","year":"1984","unstructured":"Aho K, Gordin A, Palosuo T, Punsar S, Valkeila E, Karvonen M, Inkovaara J, Pasternack A. 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Thyroid hormones and the metabolic syndrome.","journal-title":"Eur Thyroid J"},{"key":"ref=10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2174\/1871530317666170320105221","volume":"17","author":"Delitala A.P.","year":"2017","unstructured":"Delitala AP, Fanciulli G, Pes GM, Maioli M, Delitala G. Thyroid hormones, metabolic syndrome and its components.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"ref=11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12902-017-0221-3","volume":"17","author":"Raposo L.","year":"2017","unstructured":"Raposo L, Martins S, Ferreira D, Guimar\u00e3es JT, Santos AC. Vitamin D, parathyroid hormone and metabolic syndrome -The PORMETS study.","journal-title":"BMC Endocr Disord"},{"key":"ref=12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","volume":"363","author":"W.H.O Expert Consultation.","year":"2004","unstructured":"W.H.O Expert Consultation. 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Iodine intake in Portuguese pregnant women: Results of a countrywide study.","journal-title":"Eur J Endocrinol"},{"key":"ref=20","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1210\/jc.2002-020750","volume":"87","author":"Pedersen I.B.","year":"2002","unstructured":"Pedersen IB, Knudsen N, J\u00f8rgensen T, Perrild H, Ovesen L, Laurberg P. Large differences in incidences of overt hyper- and hypothyroidism associated with a small difference in iodine intake: A prospective comparative register-based population survey.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref=21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12011-015-0466-5","volume":"170","author":"Soria M.","year":"2016","unstructured":"Soria M, Anson M, Escanero JF. 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