{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:41:40Z","timestamp":1768016500949,"version":"3.49.0"},"reference-count":49,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["openmicrobiologyjournal.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["TOMICROJ"],"published-print":{"date-parts":[[2011,11,18]]},"abstract":"<jats:p>\n                    The aim of this study was to determine the effect of exogenous farnesol in yeast-to-hyphae morphogenesis, and Saps (2, 4, 5 and 6) mRNA expressions by a\n                    <jats:italic>Candida<\/jats:italic>\n                    strain that does not produce endogenous farnesol.\n                    <jats:italic>C. albicans<\/jats:italic>\n                    was cultured in the absence and presence of farnesol at various concentrations (10,\u00a0100, and 300\u00a0\u00b5M), in proteinase induction medium, and then used to determine yeast-to- hyphae changes,\n                    <jats:italic>Candida<\/jats:italic>\n                    ultrastructure and to determine Saps 2, 4, 5 and 6 expressions using q-TR-PCR and ELISA (for Sap2). Data demonstrated that farnesol greatly reduced the yeast-to-hyphae morphogenesis of a\n                    <jats:italic>Candida<\/jats:italic>\n                    strain that does not produce endogenous farnesol. Farnesol induced several ultrastructural alterations, including changes in the cell-wall shape, a visible disconnection between the cell wall and cytoplasm with an electron-lucent zone between them, and the presence of electron-dense vacuoles. Tested on gene expressions, farnesol was able to significantly (p &lt; 0.01) decrease Sap2 secretion and mRNA expression. Farnesol downregulated also Sap4-6 mRNA expression\n                    <jats:italic>.<\/jats:italic>\n                    These results demonstrated for the first time that farnesol modules\n                    <jats:italic>Candida<\/jats:italic>\n                    morphogenesis through a downregulation of Saps 2, 4, 5 and 6 expressions. Overall these data point to the potential use of farnesol as an antifungal molecule\n                  <\/jats:p>","DOI":"10.2174\/1874285801105010119","type":"journal-article","created":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T05:17:32Z","timestamp":1322457452000},"page":"119-126","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Farnesol, a Fungal Quorum-Sensing Molecule Triggers Candida Albicans Morphological Changes by Downregulating the Expression of Different Secreted Aspartyl Proteinase Genes"],"prefix":"10.2174","volume":"5","author":[{"given":"Nad\u00e8ge","family":"D\u00e9canis","sequence":"first","affiliation":[]},{"given":"Neftaha","family":"Tazi","sequence":"additional","affiliation":[]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Vilanova","sequence":"additional","affiliation":[]},{"given":"Mahmoud","family":"Rouabhia","sequence":"additional","affiliation":[]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","volume":"39","author":"Wisplinghoff H","year":"2004","unstructured":"Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. \n                    Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study \n                    Clin Infect Dis  \n                    2004; \n                    39\n                    : 309-17.","journal-title":"Clin Infect Dis"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1086\/380637","volume":"38","author":"Marchetti O","year":"2004","unstructured":"Marchetti O, Bille J, Fluckiger U, et al. \n                    Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends 1991\u20132000 \n                    Clin Infect Dis  \n                    2004; \n                    38\n                    : 311-20.","journal-title":"Clin Infect Dis"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00134-005-2794-y","volume":"31","author":"Cruciani M","year":"2005","unstructured":"Cruciani M, de Lalla F, Mengoli C. \n                    Prophylaxis of Candida infections in adult trauma and surgical intensive care patients: a systematic review and metaanalysis \n                    Intensive Care Med  \n                    2005; \n                    31\n                    : 1479-87.","journal-title":"Intensive Care Med"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1001\/archinte.1989.00390100145030","volume":"149","author":"Wey SB","year":"1989","unstructured":"Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP. \n                    Risk factors for hospital-acquired candidemia: a matched case-control study \n                    Arch Intern Med  \n                    1989; \n                    149\n                    : 2349-53.","journal-title":"Arch Intern Med"},{"key":"refR5","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.2146\/ajhp080325","volume":"66","author":"Menzin J","year":"2009","unstructured":"Menzin J, Meyers JL, Friedman M, et al. \n                    Mortality, length of hospitalization and costs associated with invasive fungal infections in high-risk patients \n                    Am J Health Syst Pharm  \n                    2009; \n                    66\n                    : 1711-7.","journal-title":"Am J Health Syst Pharm"},{"key":"refR6","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1097\/CCM.0b013e3181a0f95d","volume":"37","author":"Shorr AF","year":"2009","unstructured":"Shorr AF, Gupta V, Sun X, Johannes RS, Spalding J, Tabak YP. \n                    Burden of early-onset candidemia: analysis of culture-positive bloodstream infections from a large US database \n                    Crit Care Med  \n                    2009; \n                    37\n                    : 2519-6.","journal-title":"Crit Care Med"},{"key":"refR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408418709104444","volume":"15","author":"Odds FC","year":"1987","unstructured":"Odds FC. \n                    Candida infections: an overview \n                    Crit Rev Microbiol  \n                    1987; \n                    15\n                    : 1-5.","journal-title":"Crit Rev Microbiol"},{"key":"refR8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tim.2004.05.008","volume":"12","author":"Sudbery P","year":"2004","unstructured":"Sudbery P, Gow N, Berman J. \n                    The distinct morphogenic states of Candida albicans \n                    Trends Microbiol  \n                    2004; \n                    12\n                    : 317-24.","journal-title":"Trends Microbiol"},{"key":"refR9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1574-695X.1995.tb00077.x","volume":"11","author":"Deslauriers N","year":"1995","unstructured":"Deslauriers N, Coulombe C, Carre B, Goulet JP. \n                    Topical application of a corticosteroid destabilizes the host-parasite relationship in an experimental model of the oral carrier state of Candida albicans \n                    FEMS Immunol Med Microbiol  \n                    1995; \n                    11\n                    : 45-55.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"refR10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10454411940050020101","volume":"5","author":"Scully C","year":"1994","unstructured":"Scully C, El-Kabir M, Samaranayake LP. \n                    \n                        Candida and oral candidosis: a review \n                    Crit Rev Oral Biol Med  \n                    1994; \n                    5\n                    : 125-57.","journal-title":"Crit Rev Oral Biol Med"},{"key":"refR11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2958.2008.06528.x","volume":"71","author":"Frohner IE","year":"2009","unstructured":"Frohner IE, Bourgeois C, Yatsyk K, Majer O, Kuchler K. \n                    \n                        Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance \n                    Mol Microbiol  \n                    2009; \n                    71\n                    : 240-52.","journal-title":"Mol Microbiol"},{"key":"refR12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1073\/pnas.0804061106","volume":"106","author":"Carlisle PL","year":"2009","unstructured":"Carlisle PL, Banerjee M, Lazzell A, Monteagudo C, L\u00f3pez-Ribot JL, Kadosh D. \n                    Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence \n                    Proc Natl Acad Sci USA  \n                    2009; \n                    106\n                    : 599-604.","journal-title":"Proc Natl Acad Sci USA"},{"key":"refR13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/13693780802206435","volume":"46","author":"Tronchin G","year":"2008","unstructured":"Tronchin G, Pihet M, Lopes-Bezerra LM, Bouchara JP. \n                    Adherence mechanisms in human pathogenic fungi \n                    Med Mycol  \n                    2008; \n                    46\n                    : 749-2.","journal-title":"Med Mycol"},{"key":"refR14","first-page":"543","volume":"5","author":"Phan QT","year":"2007","unstructured":"Phan QT, Myers C, Fu Y, Sheppard DC, et al. \n                    Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells \n                    PLoS Biol  \n                    2007; \n                    5\n                    : 543-7.","journal-title":"PLoS Biol"},{"key":"refR15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1439-0507.2005.01165.x","volume":"48","author":"Schaller M","year":"2005","unstructured":"Schaller M, Borelli C, Korting HC, Hube B. \n                    Hydrolytic enzymes as virulence factors of Candida albicans \n                    Mycoses  \n                    2005; \n                    48\n                    : 365-77.","journal-title":"Mycoses"},{"key":"refR16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1462-5822.2004.00439.x","volume":"6","author":"Naglik J","year":"2004","unstructured":"Naglik J, Albrecht A, Bader O, Hube B. \n                    \n                        Candida albicans proteinases and host\/pathogen interactions \n                    Cell Microbiol  \n                    2004; \n                    6\n                    : 915-26.","journal-title":"Cell Microbiol"},{"key":"refR17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","volume":"67","author":"Naglik JR","year":"2003","unstructured":"Naglik JR, Challacombe SJ, Hube B. \n                    \n                        Candida albicans secreted\naspartyl proteinases in virulence and pathogenesis \n                    Microbiol Mol Biol Rev  \n                    2003; \n                    67\n                    : 400-28.","journal-title":"Microbiol Mol Biol Rev"},{"key":"refR18","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1099\/00221287-147-8-1997","volume":"147","author":"Hube B","year":"2001","unstructured":"Hube B, Naglik J. \n                    \n                        Candida albicans proteinases: resolving the mystery of a gene family \n                    Microbiology  \n                    2001; \n                    147\n                    : 1997-2005.","journal-title":"Microbiology"},{"key":"refR19","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1128\/jb.175.19.6126-6133.1993","volume":"175","author":"White TC","year":"1993","unstructured":"White TC, Miyasaki SH, Agabian N. \n                    Three distinct secreted aspartyl proteinases in Candida albicans \n                    J Bacteriol  \n                    1993; \n                    175\n                    : 6126-33.","journal-title":"J Bacteriol"},{"key":"refR20","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1128\/jb.177.18.5215-5221.1995","volume":"177","author":"White TC","year":"1995","unstructured":"White TC, Agabian N. \n                    \n                        Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels \nare determined by environmental factors \n                    J Bacteriol  \n                    1995; \n                    177\n                    : 5215-21.","journal-title":"J Bacteriol"},{"key":"refR21","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1074\/jbc.M509297200","volume":"281","author":"Albrecht A","year":"2006","unstructured":"Albrecht A, Felk A, Pichova I, et al. \n                    Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions \n                    J Biol Chem  \n                    2006; \n                    281\n                    : 688-94.","journal-title":"J Biol Chem"},{"key":"refR22","first-page":"75","volume":"94","author":"Odds F","year":"1997","unstructured":"Odds F. \n                    Mycology in oral pathology \n                    Acta Stomatol Belg  \n                    1997; \n                    94\n                    : 75-80.","journal-title":"Acta Stomatol Belg"},{"key":"refR23","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1128\/AEM.02765-05","volume":"72","author":"Nickerson KW","year":"2006","unstructured":"Nickerson KW, Atkin AL, Hornby JM, et al. \n                    Quorum sensing in dimorphic fungi: farnesol and beyond \n                    Appl Environ Microbiol  \n                    2006; \n                    72\n                    : 3805-13.","journal-title":"Appl Environ Microbiol"},{"key":"refR24","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1128\/AEM.67.7.2982-2992.2001","volume":"67","author":"Hornby JM","year":"2001","unstructured":"Hornby JM, Jonsen EC, Lisec AD, et al. \n                    Quorum sensing in \nthe dimorphic fungus Candida albicans is mediated by farnesol \n                    Appl Environ Microbiol  \n                    2001; \n                    67\n                    : 2982-92.","journal-title":"Appl Environ Microbiol"},{"key":"refR25","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1128\/AAC.01646-07","volume":"52","author":"Weber K","year":"2008","unstructured":"Weber K, Sohr R, Schulz B, Fleischhacker M, Ruhnke M. \n                    \nSecretion of E,E-farnesol and biofilm formation in eight different Candida species \n                    Antimicrob Agents Chemother  \n                    2008; \n                    52\n                    :  \n1859-61.","journal-title":"Antimicrob Agents Chemother"},{"key":"refR26","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1128\/AEM.68.11.5459-5463.2002","volume":"68","author":"Ramage G","year":"2002","unstructured":"Ramage G, Saville SP, Wickes BL, Lopez-Ribot JL. \n                    Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule \n                    Appl Environ Microbiol  \n                    2002; \n                    68\n                    : 5459-63.","journal-title":"Appl Environ Microbiol"},{"key":"refR27","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1139\/g05-117","volume":"49","author":"Jensen EC","year":"2006","unstructured":"Jensen EC, Hornby JM, Pagliaccetti NE, Wolter CM, Nickerson KW, Atkin AL. \n                    Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens \n                    Genome  \n                    2006; \n                    49\n                    : 346-53.","journal-title":"Genome"},{"key":"refR28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1139\/w05-050","volume":"51","author":"Braun PC","year":"2005","unstructured":"Braun PC. \n                    The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans \n                    Can J Microbiol  \n                    2005; \n                    51\n                    : 715-8.","journal-title":"Can J Microbiol"},{"key":"refR29","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1128\/EC.4.7.1203-1210.2005","volume":"4","author":"Enjalbert B","year":"2005","unstructured":"Enjalbert B, Whiteway M. \n                    Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth \n                    Eukaryot Cell  \n                    2005; \n                    4\n                    : 1203-0.","journal-title":"Eukaryot Cell"},{"key":"refR30","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1128\/AAC.48.6.2305-2307.2004","volume":"48","author":"Hornby JM","year":"2004","unstructured":"Hornby JM, Nickerson KW. \n                    Enhanced production of farnesol by Candida albicans treated with four azoles \n                    Antimicrob Agents Chemother  \n                    2004; \n                    48\n                    : 2305-7.","journal-title":"Antimicrob Agents Chemother"},{"key":"refR31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1439-0507.2008.01515.x","volume":"51","author":"Falkensammer B","year":"2008","unstructured":"Falkensammer B, Pleyer L, Ressler S, et al. \n                    Basidiomycete \nmetabolites attenuate virulence properties of Candida albicans \nin vitro \n                    Mycoses  \n                    2008; \n                    51\n                    : 505-14.","journal-title":"Mycoses"},{"key":"refR32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/yea.1389","volume":"23","author":"Saidi S","year":"2006","unstructured":"Saidi S, Luitaud C, Rouabhia M. \n                    \n                        In vitro synergistic effect of \nfarnesol and human gingival cells against Candida albicans \n                    Yeast  \n                    2006; \n                    23\n                    : 673-87.","journal-title":"Yeast"},{"key":"refR33","author":"Ausubel F M","year":"1994","unstructured":"Ausubel F M, Brent B, Kingston RE, Eds. \n                    Current\nProtocols \n                    Molecular Biology \n                    1994.","journal-title":"Molecular Biology"},{"key":"refR34","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1099\/mic.0.2008\/022293-0","volume":"154","author":"Naglik JR","year":"2008","unstructured":"Naglik JR, Moyes D, Makwana J, et al. \n                    Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis \n                    Microbiology  \n                    2008; \n                    154\n                    : 3266-80.","journal-title":"Microbiology"},{"key":"refR35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2567.2004.01819.x","volume":"111","author":"Vilanova M","year":"2004","unstructured":"Vilanova M, Teixeira L, Caramalho I, et al. \n                    Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2 \n                    Immunology  \n                    2004; \n                    111\n                    : 334-42.","journal-title":"Immunology"},{"key":"refR36","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1128\/AEM.71.8.4938-4940.2005","volume":"71","author":"Mosel DD","year":"2005","unstructured":"Mosel DD, Dumitru R, Hornby JM, Atkin AL, Nickerson KW. \n                    Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum \n                    Appl \nEnviron Microbiol  \n                    2005; \n                    71\n                    : 4938-0.","journal-title":"Appl \nEnviron Microbiol"},{"key":"refR37","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/yea.1769","volume":"27","author":"Weber K","year":"2010","unstructured":"Weber K, Schulz B, Ruhnke M. \n                    The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species \n                    Yeast  \n                    2010; \n                    27\n                    : 727-39.","journal-title":"Yeast"},{"key":"refR38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2009.05.015","volume":"287","author":"Joo JH","year":"2010","unstructured":"Joo JH, Jetten AM. \n                    Molecular mechanisms involved in farnesol-induced apoptosis \n                    Cancer Lett  \n                    2010; \n                    287\n                    : 123-35.","journal-title":"Cancer Lett"},{"key":"refR39","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/yea.1501","volume":"24","author":"Uppuluri P","year":"2007","unstructured":"Uppuluri P, Mekala S, Chaffin WL. \n                    Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue \n                    Yeast  \n                    2007; \n                    24\n                    : 681-93.","journal-title":"Yeast"},{"key":"refR40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2958.2007.06013.x","volume":"67","author":"Davis-Hanna A","year":"2008","unstructured":"Davis-Hanna A, Piispanen AE, Stateva LI, Hogan DA. \n                    Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis \n                    Mol Microbiol  \n                    2008; \n                    67\n                    : 47-62.","journal-title":"Mol Microbiol"},{"key":"refR41","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1128\/AAC.01551-08","volume":"53","author":"Shirtliff ME","year":"2009","unstructured":"Shirtliff ME, Krom BP, Meijering RA, et al. \n                    Farnesol-induced apoptosis in Candida albicans \n                    Antimicrob Agents Chemother  \n                    2009; \n                    53\n                    : 2392-401.","journal-title":"Antimicrob Agents Chemother"},{"key":"refR42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/09687860500135411","volume":"22","author":"Funari SS","year":"2005","unstructured":"Funari SS, Prades J, Escrib\u00e1 PV, Barcel\u00f3 F. \n                    Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes \n                    Mol Membr Biol  \n                    2005; \n                    22\n                    : 303-11.","journal-title":"Mol Membr Biol"},{"key":"refR43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbamem.2005.04.014","volume":"1713","author":"Rowat AC","year":"2004","unstructured":"Rowat AC, Keller D, Ipsen JH. \n                    Effects of farnesol on the physical properties of DMPC membranes \n                    Biochim Biophys Acta  \n                    2004; \n                    1713\n                    : 29-39.","journal-title":"Biochim Biophys Acta"},{"key":"refR44","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/1097-4547(20001101)62:3<396::AID-JNR10>3.0.CO;2-E","volume":"62","author":"Bringmann A","year":"2000","unstructured":"Bringmann A, Skatchkov S, Faude F, Enzmann V, Reichenbach A. \n                    Farnesol modulates membrane currents in human retinal glial cells \n                    J Neurosci Res  \n                    2000; \n                    62\n                    : 396-402.","journal-title":"J Neurosci Res"},{"key":"refR45","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1128\/AAC.50.4.1463-1469.2006","volume":"50","author":"Jabra-Rizk MA","year":"2006","unstructured":"Jabra-Rizk MA, Meiller T, James CE, Shirtliff ME. \n                    Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility \n                    Antimicrob Agents Chemother  \n                    2006; \n                    50\n                    : 1463-9.","journal-title":"Antimicrob Agents Chemother"},{"key":"refR46","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1128\/AAC.47.6.1805-1817.2003","volume":"47","author":"Niewerth M","year":"2003","unstructured":"Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, Hube B. \n                    Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors \n                    Antimicrob Agents Chemother  \n                    2003; \n                    47\n                    : 1807-7.","journal-title":"Antimicrob Agents Chemother"},{"key":"refR47","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1111\/j.1365-2672.2008.03908.x","volume":"105","author":"Le Lay C","year":"2008","unstructured":"Le Lay C, Akerey B, Fliss I, Subirade M, Rouabhia M. \n                    Nisin Z inhibits the growth of Candida albicans and its transition from blastospore to hyphal form \n                    J Appl Microbiol  \n                    2008; \n                    105\n                    : 1630-9.","journal-title":"J Appl Microbiol"},{"key":"refR48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2958.1994.tb01269.x","volume":"14","author":"Hube B","year":"1994","unstructured":"Hube B, Monod M, Schofield DA, Brown AJ, Gow NA. \n                    \nExpression of seven members of the gene family encoding \nsecretory aspartyl proteinases in Candida albicans \n                    Mol Microbiol  \n                    1994; \n                    14\n                    : 87-99.","journal-title":"Mol Microbiol"},{"key":"refR49","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1439-0507.2007.01384.x","volume":"50","author":"Lian CH","year":"2007","unstructured":"Lian CH, Liu WD. \n                    Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis \n                    Mycoses  \n                    2007; \n                    50\n                    : 383-90.","journal-title":"Mycoses"}],"container-title":["The Open Microbiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V5\/TOMICROJ-5-119\/TOMICROJ-5-119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V5\/TOMICROJ-5-119\/TOMICROJ-5-119.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openmicrobiologyjournal.com\/contents\/volumes\/V5\/TOMICROJ-5-119\/TOMICROJ-5-119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:14:44Z","timestamp":1761545684000},"score":1,"resource":{"primary":{"URL":"https:\/\/openmicrobiologyjournal.com\/VOLUME\/5\/PAGE\/119\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,18]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,11,18]]}},"alternative-id":["TOMICROJ-5-119"],"URL":"https:\/\/doi.org\/10.2174\/1874285801105010119","relation":{},"ISSN":["1874-2858"],"issn-type":[{"value":"1874-2858","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,18]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2011-7-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-8-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-8-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}