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Objective: Here, we characterized blood biomarkers\n(metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical\nfitness and quality of life (QoL) in individuals with MNCD according to NPS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The sample comprised 34 older adults (71.4% women; 74.06\u00b16.03 yrs, with MNCD diagnosis) categorized according to 50th percentile [Low (\u226412) or High (\u226513)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoLAlzheimer\u2019s Disease scale) were evaluated, and blood samples were collected for biochemical\nanalysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic zscore (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have\nhigher QoL, aerobic fitness and upper body and lower body strength.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The severity of NPS seems to be related to modified neurotrophic and inflammatory\noutcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may\npreserve the physical and mental health of individuals with MNCD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1874609816666230816090934","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T06:22:00Z","timestamp":1692253320000},"page":"74-84","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major\nNeurocognitive Disorders"],"prefix":"10.2174","volume":"17","author":[{"given":"In\u00eas","family":"Marques-Aleixo","sequence":"first","affiliation":[{"name":"Interdisciplinary Research Centre for Education and Development, Lus\u00f3fona University, Lisbon, Portugal"},{"name":"Faculty of Psychology, Education and Sport, Lus\u00f3fona University, Porto, Portugal"}]},{"given":"Arnaldina","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Lucim\u00e9re","family":"Bohn","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Centre for Education and Development, Lus\u00f3fona University, Lisbon, Portugal"},{"name":"Faculty of Psychology, Education and Sport, Lus\u00f3fona University, Porto, Portugal"},{"name":"Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Flavia","family":"Machado","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Duarte","family":"Barros","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Osc\u00e1r","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"CINTESIS - Center for Health Technology and Services Research, Department of Education and Psychology, University of Aveiro, Aveiro, Portugal"}]},{"given":"Joana","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Jos\u00e9","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sport, University of Porto, Porto, Portugal"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","volume":"396","author":"Livingston G.","year":"2020","unstructured":"Livingston G.; Huntley J.; Sommerlad A.; Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. 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