{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:05:54Z","timestamp":1768683954713,"version":"3.49.0"},"reference-count":26,"publisher":"Japan Neurosurgical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurol. Med. Chir.(Tokyo)"],"published-print":{"date-parts":[[2026,1,15]]},"DOI":"10.2176\/jns-nmc.2025-0102","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T22:06:40Z","timestamp":1764886000000},"page":"40-48","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Dynamics of Microlesion Effects in Subthalamic Local Field Potentials"],"prefix":"10.2176","volume":"66","author":[{"given":"Naoki","family":"TANI","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuto","family":"EMURA","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"KIMOTO","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"MATSUHASHI","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuto","family":"YAMAMOTO","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"HOSOMI","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"OMORI","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"OSHINO","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Ming","family":"KHOO","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"FUJITA","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"FUKUMA","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takufumi","family":"YANAGISAWA","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"KISHIMA","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"971","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Krack P, Batir A, Van Blercom NV, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson&apos;s disease. N Engl J Med. 2003;349 (20):1925-34. doi: 10.1056\/NEJMoa035275","DOI":"10.1056\/NEJMoa035275"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2) Vitek JL, Jain R, Chen L, et al. Subthalamic nucleus deep brain stimulation with a multiple independent constant current-controlled device in Parkinson&apos;s disease (INTREPID): a multicentre, double-blind, randomised, sham-controlled study. Lancet Neurol. 2020;19 (6):491-501. doi: 10.1016\/S1474-4422(20)30108-3","DOI":"10.1016\/S1474-4422(20)30108-3"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Schuepbach WMM, Rau J, Knudsen K, et al. Neurostimulation for Parkinson&apos;s disease with early motor complications. N Engl J Med. 2013;368 (7):610-22. doi: 10.1056\/NEJMoa1205158","DOI":"10.1056\/NEJMoa1205158"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4) Deffains M, Iskhakova L, Katabi S, et al. Longer \u03b2 oscillatory episodes reliably identify pathological subthalamic activity in Parkinsonism. Mov Disord. 2018;33 (10):1609-18. doi: 10.1002\/mds.27418","DOI":"10.1002\/mds.27418"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5) Wiest C, Morgante F, Torrecillos F, et al. Subthalamic nucleus stimulation-induced local field potential changes in dystonia. Mov Disord. 2023;38 (3):423-34. doi: 10.1002\/mds.29302","DOI":"10.1002\/mds.29302"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) Herrington TM, Cheng JJ, Eskandar EN. Mechanisms of deep brain stimulation. J Neurophysiol. 2016;115 (1):19-38. doi: 10.1152\/jn.00281.2015","DOI":"10.1152\/jn.00281.2015"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7) Mann JM, Foote KD, Garvan CW, et al. Brain penetration effects of microelectrodes and DBS leads in STN or GPi. J Neurol Neurosurg Psychiatry. 2009;80 (7):794-7. doi: 10.1136\/jnnp.2008.159558","DOI":"10.1136\/jnnp.2008.159558"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8) Tykocki T, Nauman P, Koziara H, et al. Microlesion effect as a predictor of the effectiveness of subthalamic deep brain stimulation for Parkinson&apos;s disease. Stereotact Funct Neurosurg. 2013;91 (1):12-7. doi: 10.1159\/000342161","DOI":"10.1159\/000342161"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9) Lange SF, Kremer NI, van Laar T, et al. The intraoperative microlesion effect positively correlates with the short-term clinical effect of deep brain stimulation in Parkinson&apos;s disease. Neuromodulation. 2021;26 (2):459-65. doi: 10.1111\/ner.13523","DOI":"10.1111\/ner.13523"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10) Vedam-Mai V, Baradaran-Shoraka M, Reynolds BA, et al. Tissue response to deep brain stimulation and microlesion: a comparative study. Neuromodulation. 2016;19 (5):451-8. doi: 10.1111\/ner.12406","DOI":"10.1111\/ner.12406"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11) Cersosimo MG, Raina GB, Benarroch EE, et al. Micro lesion effect of the globus pallidus internus and outcome with deep brain stimulation in patients with Parkinson disease and dystonia. Mov Disord. 2009;24 (10):1488-93. doi: 10.1002\/mds.22641","DOI":"10.1002\/mds.22641"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12) Gerster M, Waterstraat G, Litvak V, et al. Separating neural oscillations from aperiodic 1\/f activity: challenges and recommendations. Neuroinformatics. 2022;20 (4):991-1012. doi: 10.1007\/s12021-022-09581-8","DOI":"10.1007\/s12021-022-09581-8"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13) Darmani G, Drummond NM, Ramezanpour H, et al. Long-term recording of subthalamic aperiodic activities and beta bursts in Parkinson&apos;s disease. Mov Disord. 2023;38 (2):232-43. doi: 10.1002\/mds.29276","DOI":"10.1002\/mds.29276"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14) Little S, Pogosyan A, Neal S, et al. Adaptive deep brain stimulation in advanced Parkinson disease. Ann Neurol. 2013;74 (3):449-57. doi: 10.1002\/ana.23951","DOI":"10.1002\/ana.23951"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15) Wiest C, Torrecillos F, Pogosyan A, et al. The aperiodic exponent of subthalamic field potentials reflects excitation\/inhibition balance in Parkinsonism. eLife. 2023;12:e82467. doi: 10.7554\/eLife.82467","DOI":"10.7554\/eLife.82467"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16) Winawer J, Kay KN, Foster BL, et al. Asynchronous broadband signals are the principal source of the BOLD response in human visual cortex. Curr Biol. 2013;23 (13):1145-53. doi: 10.1016\/j.cub.2013.05.001","DOI":"10.1016\/j.cub.2013.05.001"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17) Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson&apos;s disease. Mov Disord. 2015;30 (12):1591-601. doi: 10.1002\/mds.26424","DOI":"10.1002\/mds.26424"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18) Yamamoto K, Higuchi H, Fukui K, et al. Stereotactic functional neurosurgery combining sedation and awake procedures using remimazolam besylate and flumazenil: a technical note. Neurol Med Chir (Tokyo). 2025;0011. doi: 10.2176\/jns-nmc.2025-0011","DOI":"10.2176\/jns-nmc.2025-0011"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) Nyholm D, Jost WH. An updated calculator for determining levodopa-equivalent dose. Neurol Res Pract. 2021;3 (1):58. doi: 10.1186\/s42466-021-00157-6","DOI":"10.1186\/s42466-021-00157-6"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20) Donoghue T, Haller M, Peterson EJ, et al. Parameterizing neural power spectra into periodic and aperiodic components. Nat Neurosci. 2020;23 (12):1655-65. doi: 10.1038\/s41593-020-00744-x","DOI":"10.1038\/s41593-020-00744-x"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21) Schmidt SL, Peters JJ, Turner DA, et al. Continuous deep brain stimulation of the subthalamic nucleus may not modulate beta bursts in patients with Parkinson&apos;s disease. Brain Stimul. 2020;13 (2):433-43. doi: 10.1016\/j.brs.2019.12.008","DOI":"10.1016\/j.brs.2019.12.008"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22) Gao R, Peterson EJ, Voytek B. Inferring synaptic excitation\/inhibition balance from field potentials. NeuroImage. 2017;158:70-8. doi: 10.1016\/j.neuroimage.2017.06.078","DOI":"10.1016\/j.neuroimage.2017.06.078"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) Peng C, Wang Z, Sun Y, et al. Subthalamic nucleus dynamics track microlesion effect in Parkinson&apos;s disease. Front Cell Dev Biol. 2024;12:1370287. doi: 10.3389\/fcell.2024.1370287","DOI":"10.3389\/fcell.2024.1370287"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24) Liu X, Guang J, Glowinsky S, et al. Subthalamic nucleus input-output dynamics are correlated with Parkinson&apos;s burden and treatment efficacy. NPJ Parkinsons Dis. 2024;10 (1):117. doi: 10.1038\/s41531-024-00737-8","DOI":"10.1038\/s41531-024-00737-8"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25) Anderson RW, Wilkins KB, Parker JE, et al. Lack of progression of beta dynamics after long-term subthalamic neurostimulation. Ann Clin Transl Neurol. 2021;8 (11):2110-20. doi: 10.1002\/acn3.51463","DOI":"10.1002\/acn3.51463"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26) Mori F, Fukaya C, Watanabe M, et al. Gender difference in outcome of subthalamic nucleus-deep brain stimulation in Japan. Neurol Med Chir (Tokyo). 2025;65 (3):126-32. doi: 10.2176\/jns-nmc.2024-0108","DOI":"10.2176\/jns-nmc.2024-0108"}],"container-title":["Neurologia medico-chirurgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/nmc\/66\/1\/66_2025-0102\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:22:10Z","timestamp":1768623730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/nmc\/66\/1\/66_2025-0102\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2176\/jns-nmc.2025-0102","relation":{},"ISSN":["0470-8105","1349-8029"],"issn-type":[{"value":"0470-8105","type":"print"},{"value":"1349-8029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"article-number":"2025-0102"}}