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1998."},{"key":"9","unstructured":"9) Kelley VR, Wuthrich RP : Cytokines in the pathogenesis of systemic lupus erythematosus. <i>Semin Nephrol<\/i> <b>19<\/b> : 57-66, 1999."},{"key":"10","unstructured":"10) Chang JT, Segal BM, Nakanishi K, et al. : The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. <i>Eur J Immunol<\/i> <b>30<\/b> : 1113-1119, 2000."},{"key":"11","unstructured":"11) Akahoshi M, Nakashima H, Tanaka Y, et al. : Th1\/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. <i>Arthritis Rheum<\/i> <b>42<\/b> : 1644-1648, 1999."},{"key":"12","unstructured":"12) Masutani K, Akahoshi M, Tsuruya K, et al. : Predominance of Th1 immune response in diffuse proliferative lupus nephritis. <i>Arthritis Rheum<\/i> <b>44<\/b> : 2097-2106, 2001."},{"key":"13","unstructured":"13) Schwarting A, Wada T, Kinoshita K, et al. : IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas (lpr) mice. <i>J Immunol<\/i> <b>161<\/b> : 494-503, 1998."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Haas C, Ryffel B, Le Hir M : IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL\/Ipr mice. <i>J Immunol<\/i> <b>158<\/b> : 5484-5491, 1997.","DOI":"10.4049\/jimmunol.158.11.5484"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kikawada E, Lenda DM, Kelley VR : IL-12 deficiency in MRL-Fas (lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. <i>J Immunol<\/i> <b>170<\/b> : 3915-3925, 2003.","DOI":"10.4049\/jimmunol.170.7.3915"},{"key":"16","unstructured":"16) Shimizu S, Sugiyama N, Masutani K, et al. : Membranous glomerulonephritis development with Th2-type immune deviations in MRL\/lpr mice deficient for IL-27 receptor (WSX-1). <i>J Immunol<\/i> <b>175<\/b> : 7185-7192, 2005."},{"key":"17","unstructured":"17) Dolff S, Quandt D, Wilde B, et al. : Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus. <i>Arthritis Res Ther<\/i> <b>12<\/b> : R150, 2010."},{"key":"18","unstructured":"18) Mangan PR, Harrington LE, O'quinn DB, et al. : Transforming growth factor-beta induces development of the T(H)17 lineage. <i>Nature<\/i> <b>441<\/b> : 231-234, 2006."},{"key":"19","unstructured":"19) Cash H, Relle M, Menke J, et al. : Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Fas lpr mice : the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. <i>J Rheumatol<\/i> <b>37<\/b> : 60-70, 2009."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Horwitz DA, Zheng SG, Gray JD : Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of 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