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Am J Pathol<\/i>. 184<\/b>: 2699-2708, 2014."},{"key":"7","unstructured":"7) Asanuma, K., et al.: Dendrin location in podocytes is associated with disease progression in animal and human glomerulopathy. Am J Nephrol<\/i>. 33<\/b>: 537-549, 2011."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kriz, W., Lemley, K.V.: A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD. J Am Soc Nephrol<\/i>. 2014.","DOI":"10.1681\/ASN.2014030278"},{"key":"9","unstructured":"9) Kriz, W., et al.: Progression of glomerular diseases: is the podocyte the culprit? Kidney Int<\/i>. 54<\/b>: 687-697, 1998."},{"key":"10","unstructured":"10) Suzuki, T., et al.: Genetic podocyte lineage reveals progressive podocytopenia with parietal cell hyperplasia in a murine model of cellular\/collapsing focal segmental glomerulosclerosis. Am J Pathol<\/i>. 174<\/b>: 1675-1682, 2009."},{"key":"11","unstructured":"11) Matsusaka, T., et al.: Podocyte injury damages other podocytes. J Am Soc Nephrol<\/i>. 22<\/b>: 1275-1285, 2011."},{"key":"12","unstructured":"12) Asanuma, K., et al.: Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes. Proc Natl Acad Sci U S A<\/i>. 104<\/b>: 10134-10139, 2007."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Shankland, S.J.: The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int<\/i>. 69<\/b>: 2131-2147, 2006.","DOI":"10.1038\/sj.ki.5000410"},{"key":"14","unstructured":"14) Shih, N.Y., et al.: CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol<\/i>. 159<\/b>: 2303-2308, 2001."},{"key":"15","unstructured":"15) Huber, T.B., et al.: Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. 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J Biochem<\/i>. 139<\/b>: 931-939, 2006."},{"key":"20","unstructured":"20) Kodama, F., et al.: Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy. Nephrol Dial Transplant<\/i>. 28<\/b>: 1762-1772, 2013."},{"key":"21","unstructured":"21) Hara, M., et al.: Urinary podocytes in primary focal segmental glomerulosclerosis. Nephron<\/i>. 89<\/b>: 342-347, 2001."},{"key":"22","unstructured":"22) Hara, M., et al.: Urinary excretion of podocytes reflects disease activity in children with glomerulonephritis. Am J Nephrol<\/i>. 18<\/b>: 35-41, 1998."},{"key":"23","unstructured":"23) Jefferson, J.A., et al.: Podocyte biology for the bedside. Am J Kidney Dis<\/i>. 58<\/b>: 835-845, 2011."},{"key":"24","unstructured":"24) Asao, R., et al.: Relationships between levels of urinary podocalyxin, number of urinary podocytes, and histologic injury in adult patients with IgA nephropathy. Clin J Am Soc Nephrol<\/i>. 7<\/b>: 1385-1393, 2012."},{"key":"25","unstructured":"25) Hara, M., et al.: Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of podocyte injury. J Am Soc Nephrol<\/i>. 16<\/b>: 408-416, 2005."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Nielsen, J.S., McNagny, K.M.: The role of podocalyxin in health and disease. J Am Soc Nephrol<\/i>. 20<\/b>: 1669-1676, 2009.","DOI":"10.1681\/ASN.2008070782"},{"key":"27","unstructured":"27) Hara, M., et al.: Podocyte membrane vesicles in urine originate from tip vesiculation of podocyte microvilli. Hum Pathol<\/i>. 41<\/b>: 1265-1275, 2010."},{"key":"28","unstructured":"28) Kanno, K., et al.: Urinary sediment podocalyxin in children with glomerular diseases. Nephron Clin Pract<\/i>. 95<\/b>: c91-99, 2003."},{"key":"29","unstructured":"29) Hara, M., et al.: Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin. Diabetologia<\/i>. 55<\/b>: 2913-2919, 2012."},{"key":"30","unstructured":"30) Bao, H., et al.: Successful treatment of class V+IV lupus nephritis with multitarget therapy. J Am Soc Nephrol<\/i>. 19<\/b>: 2001-2010, 2008."},{"key":"31","unstructured":"31) Iijima, K., et al.: Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet<\/i>. 384<\/b>: 1273-1281, 2014."},{"key":"32","unstructured":"32) Shalhoub, R.J.: Pathogenesis of lipoid nephrosis: a disorder of T-cell function. 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