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Endocrinol<\/i>. 138<\/b>: 947-954, 1997."},{"key":"3","unstructured":"3) Vaisse, C., et al.: Leptin activation of Stat3 in the hypothalamus of wild-type and ob\/ob<\/i> mice but db\/db<\/i> mice. Nature Genet<\/i>. 14<\/b>: 95-97, 1996."},{"key":"4","unstructured":"4) Hoggard, N., et al.: Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem Biophys Res Commun<\/i>. 232<\/b>: 383-387, 1997."},{"key":"5","unstructured":"5) Cioffi, J.A., et al.: Novel B219\/OB receptor isoforms: possible roles of leptin in hematopoiesis and reproduction. Nature Med<\/i>. 2<\/b>: 585-589, 1996."},{"key":"6","unstructured":"6) Kimura, M., et al.: T lymphopenia in obese diabetic (db\/db<\/i>) mice is non-selective and thymus independent. Life Sci<\/i>. 62<\/b>: 1243-1250, 1998."},{"key":"7","unstructured":"7) Sanchez-Margalet, V., et al.: Human leptin signaling in human peripheral blood mononuclear cells. Cell Immunol<\/i>. 211<\/b>: 30-36, 2001."},{"key":"8","unstructured":"8) De Rosa, V., et al.: A key role of leptin in the control of regulatory T cell proliferation. Immunity<\/i>. 26<\/b>: 241-255, 2007."},{"key":"9","unstructured":"9) Fujita, Y., et al.: Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol<\/i>. 128<\/b>: 21-26, 2002."},{"key":"10","unstructured":"10) Amarilyo, G., et al.: Leptin promotes lupus T-cell autoimmunity. Clin Immunol<\/i>. 149<\/b>: 530-533, 2013."},{"key":"11","unstructured":"11) Batra, A., et al.: Leptin: a critical regulator of CD4+<\/sup>T-cell polarization in vitro and in vivo. Endocrinol<\/i>. 151<\/b>: 56-62, 2010."},{"key":"12","unstructured":"12) Procaccini, C., et al.: Leptin induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+<\/sup> effector T cell responses. J Immunol<\/i>. 189<\/b>: 2941-2953, 2012."},{"key":"13","unstructured":"13) Ma, L., et al.: Elevated serum leptin levels in patients with systemic lupus erythematosus. Pharmazie<\/i>. 70<\/b>: 720-723, 2015."},{"key":"14","unstructured":"14) Liu, Y., et al.: A cutting edge: Fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. J Immunol<\/i>. 188<\/b>: 2070-2073, 2012."},{"key":"15","unstructured":"15) Fujita, Y., et al.: Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL\/Mp-lpr mice. J Immunol<\/i>. 192<\/b>: 979-984, 2014."},{"key":"16","unstructured":"16) Margiotta, D., et al.: Relationship between leptin and regulatory T cells in systemic lupus erythematosus: preliminary results. Eur Rev Med Pharmacol Sci<\/i>. 20<\/b>: 636-641, 2016."},{"key":"17","unstructured":"17) Deng, J., et al.: Leptin exacerbates collagen-induced arthritis via enhancement of Tn17 cell response. Arthritis Rheumatol<\/i>. 64<\/b>: 3564-3573, 2012."},{"key":"18","unstructured":"18) Reis, B.S., et al.: Leptin receptor signaling in T cells is required for Th17 differentiation. J Immunol<\/i>. 194<\/b>: 5253-5269, 2015."},{"key":"19","unstructured":"19) Claycombe, K., et al.: A role for leptin in sustaining lymphopoiesis and myelopoiesis. Proc Natl Acad Sci USA<\/i>. 105<\/b>: 2017-2021, 2008."},{"key":"20","unstructured":"20) Lam, Q.L.K., et al.: Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1. Proc Natl Acad Sci USA<\/i>. 107<\/b>: 13812-13817, 2010."},{"key":"21","unstructured":"21) Agrawal, S., et al.: Leptin activates human B cells to secrete TNF\u03b1, IL-6 and IL-10 via JAK2\/STAT3 and p38MAPK\/ERK1\/2 signaling pathway. J Clin Immunol<\/i>. 31<\/b>: 472-478, 2011."},{"key":"22","unstructured":"22) Fujita, Y., et al.: Prevention of fasting-mediated bone marrow atrophy by leptin administration. Cell Immunol<\/i>. 237<\/b>: 52-58, 2012."},{"key":"23","unstructured":"23) Otero, M., et al.: Changes in plasma levels of fat derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis<\/i>. 65<\/b>: 1198-1201, 2006."},{"key":"24","unstructured":"24) Targonska-Stepniak, B., et al.: Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity. Rheumatol Int<\/i>. 28<\/b>: 585-591, 2008."},{"key":"25","unstructured":"25) Hizmetli, S., et al.: Are plasma and synovial fluid leptin levels correlated with disease activity in rheumatoid arthritis? Rheumatol Int<\/i>. 27<\/b>: 335-338, 2007."},{"key":"26","unstructured":"26) Olama, S., et al.: Synovial\/serum leptin ratio in rheumatoid arthritis: the association with activity and erosion. Rheumatol Int<\/i>. 32<\/b>: 683-690, 2012."},{"key":"27","unstructured":"27) Xibille-Friedmann, D., et al.: Two-year follow-up of plasma leptin and other cytokines in patients with rheumatoid arthritis. Ann Rheum Dis<\/i>. 69<\/b>: 930-931, 2010."},{"key":"28","unstructured":"28) La Cava, A., et al.: The weight of leptin in immunity. Nat Rev Immunol<\/i>. 4<\/b>: 371-379, 2001."},{"key":"29","unstructured":"29) Busso, N., et al.: Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol<\/i>. 168<\/b>: 875-882, 2002."},{"key":"30","unstructured":"30) McMahon, M., et al.: High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidized lipids. Ann Rheum Dis<\/i>. 70<\/b>: 87-95, 2007."},{"key":"31","unstructured":"31) Wislowska, M., et al.: Serum leptin in systemic lupus erythematosus. 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