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(1980) Elimination of synapses in the developing nervous system. Science <b>210<\/b>, 153-157.","DOI":"10.1126\/science.7414326"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Lichtman, J.W. and Colman, H. (2000) Synapse elimination and indelible memory. Neuron. <b>25<\/b>, 269-278.","DOI":"10.1016\/S0896-6273(00)80893-4"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kano, M. and Hashimoto, K. (2009) Synapse elimination in the central nervous system. Curr. Opin. Neurobiol. <b>19<\/b>, 154-161.","DOI":"10.1016\/j.conb.2009.05.002"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Riccomagno, M.M. and Kolodkin, A.L. (2015) Sculpting neural circuits by axon and dendrite pruning. Annu. Rev. Cell Dev. Biol. <b>31<\/b>, 779-805.","DOI":"10.1146\/annurev-cellbio-100913-013038"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Faust, T.E., Gunner, G. and Schafer, D.P. (2021) Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS. Nat. Rev. Neurosci. <b>22<\/b>, 657-673.","DOI":"10.1038\/s41583-021-00507-y"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Kano, M., Watanabe, T., Uesaka, N. and Watanabe, M. (2018) Multiple phases of climbing fiber synapse elimination in the developing cerebellum. Cerebellum <b>17<\/b>, 722-734.","DOI":"10.1007\/s12311-018-0964-z"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kano, M. and Watanabe, T. (2019) Developmental synapse remodeling in the cerebellum and visual thalamus. F1000Research <b>8<\/b>, 1191.","DOI":"10.12688\/f1000research.18903.1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Watanabe, M. and Kano, M. (2011) Climbing fiber synapse elimination in cerebellar Purkinje cells. Euro. J. Neuroscience <b>34<\/b>, 1697-1710.","DOI":"10.1111\/j.1460-9568.2011.07894.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hashimoto, K. and Kano, M. (2013) Synapse elimination in the developing cerebellum. Cell. Mol. Life Sci. <b>70<\/b>, 4667-4680.","DOI":"10.1007\/s00018-013-1405-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Penzes, P., Cahill, M.E., Jones, K.A., Vanleeuwen, J.E. and Woolfrey, K.M. (2011) Dendritic spine pathology in neuropsychiatric disorders. Nat. Neurosci. <b>14<\/b>, 285-293.","DOI":"10.1038\/nn.2741"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Wang, S.S.H., Kloth, A.D. and Badura, A. (2014) The cerebellum, sensitive periods, and autism. Neuron. <b>83<\/b>, 518-532.","DOI":"10.1016\/j.neuron.2014.07.016"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Eccles, J.C., Ito, M. and Szent\u00e1gothai, J. (1967) The Cerebellum as a Neuronal Machine. Springer Science+Business Media, New York.","DOI":"10.1007\/978-3-662-13147-3"},{"key":"13","unstructured":"13) Ito, M. (1984) The Cerebellum and Neural Control. Raven Press, New York."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Napper, R.M.A. and Harvey, R.J. (1988) Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat. J Comp Neurol. <b>274<\/b>, 168-177.","DOI":"10.1002\/cne.902740204"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kano, M., Hashimoto, K., Chen, C., Abeliovich, A., Aiba, A., Kurihara, H. <i>et al<\/i>. (1995) Impaired synapse elimination during cerebellar development in PKC\u03b3 mutant mice. Cell <b>83<\/b>, 1223-1231.","DOI":"10.1016\/0092-8674(95)90147-7"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Busch, S.E. and Hansel, C. (2023) Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human. Science <b>381<\/b>, 420-427.","DOI":"10.1126\/science.adi1024"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sillitoe, R. V. and Hawkes, R. (2002) Whole-mount immunohistochemistry: A high-throughput screen for patterning defects in the mouse cerebellum. J. Histochem. Cytochem. <b>50<\/b>, 235-244.","DOI":"10.1177\/002215540205000211"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Rai, Y., Watanabe, T., Matsuyama, K., Sakimura, K., Uesaka, N. and Kano, M. (2021) Phospholipase C \u03b23 is required for climbing fiber synapse elimination in aldolase C-positive compartments of the developing mouse cerebellum. Neuroscience <b>462<\/b>, 36-43.","DOI":"10.1016\/j.neuroscience.2020.04.035"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Sugihara, I. (2005) Microzonal projection and climbing fiber remodeling in single olivocerebellar axons of newborn rats at postnatal days 4-7. J. Comp. Neurol. <b>487<\/b>, 93-106.","DOI":"10.1002\/cne.20531"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Wilson, A.M., Schalek, R., Suissa-Peleg, A., Jones, T.R., Knowles-Barley, S., Pfister, H. <i>et al<\/i>. (2019) Developmental rewiring between cerebellar climbing fibers and Purkinje cells begins with positive feedback synapse addition. Cell Rep. <b>29<\/b>, 2849-2861.e6.","DOI":"10.1016\/j.celrep.2019.10.081"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M. and Kano, M. (2009) Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses in the cerebellum. Neuroscience <b>162<\/b>, 601-611.","DOI":"10.1016\/j.neuroscience.2008.12.037"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Hashimoto, K. and Kano, M. (2003) Functional differentiation of multiple climbing fiber inputs during synapse elimination in the developing cerebellum. Neuron <b>38<\/b>, 785-796.","DOI":"10.1016\/S0896-6273(03)00298-8"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Hashimoto, K., Ichikawa, R., Kitamura, K., Watanabe, M. and Kano, M. (2009) Translocation of a \u201cwinner\u201d climbing fiber to the Purkinje cell dendrite and subsequent elimination of \u201closers\u201d from the soma in developing cerebellum. Neuron. <b>63<\/b>, 106-118.","DOI":"10.1016\/j.neuron.2009.06.008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Hashimoto, K., Tsujita, M., Miyazaki, T., Kitamura, K., Yamazaki, M., Shin, H.S. <i>et al<\/i>. (2011) Postsynaptic P\/Q-type Ca<sup>2+<\/sup> channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc. Natl. Acad. Sci. U.S.A. <b>108<\/b>, 9987-9992.","DOI":"10.1073\/pnas.1101488108"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Chen, L.Y., Jiang, M., Zhang, B., Gokce, O. and S\u00fcdhof, T.C. (2017) Conditional deletion of all neurexins defines diversity of essential synaptic organizer functions for neurexins. Neuron <b>94<\/b>, 611-625.e4.","DOI":"10.1016\/j.neuron.2017.04.011"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Zhang, B., Chen, L.Y., Liu, X., Maxeiner, S., Lee, S.J., Gokce, O. <i>et al<\/i>. (2015) Neuroligins sculpt cerebellar Purkinje cell circuits by differential control of distinct classes of synapses. Neuron. <b>87<\/b>, 781-796.","DOI":"10.1016\/j.neuron.2015.07.020"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Okuno, Y., Sakoori, K., Matsuyama, K., Yamasaki, M., Watanabe, M., Hashimoto, K. <i>et al.<\/i> (2023) PTP\u03b4 is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum. Front. Mol. Neurosci. <b>16<\/b>, 1206245.","DOI":"10.3389\/fnmol.2023.1206245"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Lorenzetto, E., Caselli, L., Feng, G., Yuan, W., Nerbonne, J.M., Sanes, J.R. <i>et al<\/i>. (2009) Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum. Proc. Natl. Acad. Sci. U.S.A. <b>106<\/b>, 16475-16480.","DOI":"10.1073\/pnas.0907298106"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Andjus, P.R., Zhu, L., Cesa, R., Carulli, D. and Strata, P.A. (2003) change in the pattern of activity affects the developmental regression of the Purkinje cell polyinnervation by climbing fibers in the rat cerebellum. Neuroscience. <b>121<\/b>, 563-572.","DOI":"10.1016\/S0306-4522(03)00556-6"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Miyazaki, T., Hashimoto, K., Shin, H.S., Kano, M. and Watanabe, M. (2004) P\/Q-type Ca<sup>2+<\/sup> channel \u03b11A regulates synaptic competition on developing cerebellar Purkinje cells. J. Neurosci. <b>24<\/b>, 1734-1743.","DOI":"10.1523\/JNEUROSCI.4208-03.2004"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Mikuni, T., Uesaka, N., Okuno, H., Hirai, H., Deisseroth, K., Bito, H. <i>et al<\/i>. (2013) Arc\/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron <b>78<\/b>, 1024-1035.","DOI":"10.1016\/j.neuron.2013.04.036"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Nakayama, H., Miyazaki, T., Kitamura, K., Hashimoto, K., Yanagawa, Y., Obata, K. <i>et al<\/i>. (2012) GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Neuron <b>74<\/b>, 384-396.","DOI":"10.1016\/j.neuron.2012.02.032"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kawata, S., Miyazaki, T., Yamazaki, M., Mikuni, T., Yamasaki, M., Hashimoto, K. <i>et al<\/i>. (2014) Global scaling down of excitatory postsynaptic responses in cerebellar Purkinje cells impairs developmental synapse elimination. Cell Rep. <b>8<\/b>, 1119-1129.","DOI":"10.1016\/j.celrep.2014.07.014"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kano, M., Hashimoto, K., Kurihara, H., Watanabe, M., Inoue, Y., Aiba, A. <i>et al<\/i>. (1997) Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron <b>18<\/b>, 71-79.","DOI":"10.1016\/S0896-6273(01)80047-7"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R. <i>et al<\/i>. (2000) mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science <b>288<\/b>, 1832-1835.","DOI":"10.1126\/science.288.5472.1832"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Offermanns, S., Hashimoto, K., Watanabe, M., Sun, W., Kurihara, H., Thompson, R.F. <i>et al<\/i>. (1997) Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G\u03b1q. Proc. Natl. Acad. Sci. U.S.A. <b>94<\/b>, 14089-14094.","DOI":"10.1073\/pnas.94.25.14089"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Kano, M., Hashimoto, K., Watanabe, M., Kurihara, H., Offermanns, S., Jiang, H. <i>et al<\/i>. (1998) Phospholipase C\u03b24 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc. Natl. Acad. Sci. U.S.A. <b>95<\/b>, 15724-15729.","DOI":"10.1073\/pnas.95.26.15724"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Chen, C., Kano, M., Abeliovich, A., Chen, L., Bao, S., Kim, J.J. <i>et al<\/i>. (1995) Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC\u03b3 mutant mice. Cell <b>83<\/b>, 1233-1242.","DOI":"10.1016\/0092-8674(95)90148-5"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Batchelor, A.M. and Garthwaite, J. (1997) Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway. Nature <b>385<\/b>, 74-77.","DOI":"10.1038\/385074a0"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Finch, E.A. and Augustine, G.J. (1998) Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Nature. <b>396<\/b>, 753-756.","DOI":"10.1038\/25541"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Takechi, H., Eilers, J. and Konnerth, A. (1998) A new class of synaptic response involving calcium release in dendritic spines. Nature <b>396<\/b>, 757-760.","DOI":"10.1038\/25547"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Nakayama, H., Miyazaki, T., Abe, M., Yamazaki, M., Kawamura, Y., Choo, M. <i>et al<\/i>. (2024) Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum. Commun. Biol. <b>7<\/b>, 806.","DOI":"10.1038\/s42003-024-06447-4"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Sarna, J.R., Marzban, H., Watanabe, M. and Hawkes, R. (2006) Complementary stripes of phospholipase C\u03b23 and C\u03b24 expression by Purkinje cell subsets in the mouse cerebellum. J. Comp. Neurol. <b>496<\/b>, 303-313.","DOI":"10.1002\/cne.20912"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Uesaka, N., Uchigashima, M., Mikuni, T., Nakazawa, T., Nakao, H., Hirai, H. <i>et al<\/i>. (2014) Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain. Science <b>344<\/b>, 1020-1023.","DOI":"10.1126\/science.1252514"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Choo, M., Miyazaki, T., Yamazaki, M., Kawamura, M., Nakazawa, T., Zhang, J. <i>et al<\/i>. (2017) Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. Nat Commun. <b>8<\/b>, 195.","DOI":"10.1038\/s41467-017-00260-w"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Uesaka, N., Abe, M., Konno, K., Yamazaki, M., Sakoori, K., Watanabe, T. <i>et al<\/i>. (2018) Retrograde signaling from progranulin to sort1 counteracts synapse elimination in the developing cerebellum. Neuron. <b>97<\/b>, 796-805.e5.","DOI":"10.1016\/j.neuron.2018.01.018"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Kakegawa, W., Mitakidis, N., Miura, E., Abe, M., Matsuda, K., Takeo, Y.H. <i>et al<\/i>. (2015) Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron <b>85<\/b>, 316-329.","DOI":"10.1016\/j.neuron.2014.12.020"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Altman, J. and Anderson, W.J. (1972) Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of all microneurons with prolonged x-irradiation started at birth. J. Comp. Neurol. <b>146<\/b>, 355-405.","DOI":"10.1002\/cne.901460305"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Hirai, H., Pang, Z., Bao, D., Miyazaki, T., Li, L., Miura, E. <i>et al<\/i>. (2005) Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Nat. Neurosci. <b>8<\/b>, 1534-1541.","DOI":"10.1038\/nn1576"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Uemura, T., Lee, S.J., Yasumura, M., Takeuchi, T., Yoshida, T., Ra, M. <i>et al<\/i>. (2010) Trans-synaptic interaction of GluR\u03b42 and neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell. <b>141<\/b>, 1068-1079.","DOI":"10.1016\/j.cell.2010.04.035"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S. <i>et al<\/i>. (2010) Cbln1 is a ligand for an orphan glutamate receptor \u03b42, a bidirectional synapse organizer. Science <b>328<\/b>, 363-368.","DOI":"10.1126\/science.1185152"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Hashimoto, K., Ichikawa, R., Takechi, H., Inoue, Y., Aiba, A., Sakimura, K. <i>et al<\/i>. (2001) Roles of glutamate receptor \u03b42 subunit (GluR\u03b42) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development. J. Neurosci. <b>21<\/b>, 9701-9712.","DOI":"10.1523\/JNEUROSCI.21-24-09701.2001"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Yamasaki, M., Miyazaki, T., Azechi, H., Abe, M., Natsume, R., Hagiwara, T. <i>et al<\/i>. (2011)Glutamate receptor \u03b42 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells. J. Neurosci. <b>31<\/b>, 3362-3374.","DOI":"10.1523\/JNEUROSCI.5601-10.2011"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K. <i>et al<\/i>. (2002) Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar purkinje cells lacking glutamate receptor \u03b42. J. Neurosci. <b>22<\/b>, 8487-8503.","DOI":"10.1523\/JNEUROSCI.22-19-08487.2002"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Miyazaki, T., Yamasaki, M., Takeuchi, T., Saki- mura, K., Mishina, M. and Watanabe, M. (2010) Ablation of glutamate receptor glur\u03b42 in adult Purkinje cells causes multiple innervation of climbing fibers by inducing aberrant invasion to parallel fiber innervation territory. J. Neurosci. <b>30<\/b>, 15196-15209.","DOI":"10.1523\/JNEUROSCI.0934-10.2010"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Aimi, T., Matsuda, K. and Yuzaki, M. (2023) C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity. Mol. Brain. <b>16<\/b>, 61.","DOI":"10.1186\/s13041-023-01048-4"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Oostland, M., Sellmeijer, J. and Van Hooft, J.A. (2011) Transient expression of functional serotonin 5-HT 3 receptors by glutamatergic granule cells in the early postnatal mouse cerebellum. J. Physiol. <b>589<\/b>, 4837-4846.","DOI":"10.1113\/jphysiol.2011.217307"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Oostland, M., Buijink, M.R. and van Hooft, J.A. (2013) Serotonergic control of Purkinje cell maturation and climbing fibre elimination by 5-HT3 receptors in the juvenile mouse cerebellum. J. Physiol. <b>591<\/b>, 1793-1807.","DOI":"10.1113\/jphysiol.2012.246413"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Ichikawa, R., Hashimoto, K., Miyazaki, T., Uchigashima, M., Yamasaki, M., Aiba, A. <i>et al<\/i>. (2016) Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. Proc. Natl. Acad. Sci. U.S.A. <b>113<\/b>, 2282-2287.","DOI":"10.1073\/pnas.1511513113"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Kakizawa, S., Yamasaki, M., Watanabe, M. and Kano, M. (2000) Critical period for activity-dependent synapse elimination in developing cerebellum. J. Neurosci. <b>20<\/b>, 4954-4961.","DOI":"10.1523\/JNEUROSCI.20-13-04954.2000"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Rabacchi, S., Bailly, Y., Delhaye-Bouchaud, N. and Maraini, J. (1992) Involvement of the N-methyl D-aspartate (NMDA) receptor in synapse elimination during cerebellar development. Science <b>256<\/b>, 1823-1825.","DOI":"10.1126\/science.1352066"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Stephan, A.H., Barres, B.A. and Stevens, B. (2012) The complement system: An unexpected role in synaptic pruning during development and disease. Annu. Rev. Neurosci. <b>35<\/b>, 369-389.","DOI":"10.1146\/annurev-neuro-061010-113810"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Neniskyte, U. and Gross, C.T. (2017) Errant gardeners: Glial-cell-dependent synaptic pruning and neurodevelopmental disorders. Nat. Rev. Neurosci. <b>18<\/b>, 658-670.","DOI":"10.1038\/nrn.2017.110"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Nakayama, H., Abe, M., Morimoto, C., Iida, T., Okabe, S., Sakimura, K. <i>et al<\/i>. (2018) Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum. Nat. Commun. <b>9<\/b>, 2830.","DOI":"10.1038\/s41467-018-05100-z"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Parkhurst, C.N., Yang, G., Ninan, I., Savas, J.N., Yates, J.R., Lafaille, J.J. <i>et al<\/i>. (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell <b>155<\/b>, 1596-1609.","DOI":"10.1016\/j.cell.2013.11.030"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66) Bosman, L.W.J., Hartmann, J., Barski, J.J., Lepier, A., Noll-Hussong, M., Reichardt, L.F. <i>et al<\/i>. (2007) Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells. Brain Cell Biol. <b>35<\/b>, 87-101.","DOI":"10.1007\/s11068-006-9002-z"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Rico, B., Xu, B. and Reichardt, L.F. (2002) TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum. Nat. Neurosci. <b>5<\/b>, 225-233.","DOI":"10.1038\/nn808"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68) Serantes, R., Arnalich, F., Figueroa, M., Salinas, M., Andr\u00e9s-Mateos, E., Codoceo, R. <i>et al<\/i>. (2006) Interleukin-1\u03b2 enhances GABA<sub>A<\/sub> receptor cell-surface expression by a phosphatidylinositol 3-kinase\/Akt pathway. J. Biol. Chem. <b>281<\/b>, 14632-14643.","DOI":"10.1074\/jbc.M512489200"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) St\u00fcck, E.D., Christensen, R.N., Huie, J.R., Tovar, C.A., Miller, B.A., Nout, Y.S. <i>et al<\/i>. (2012) Tumor necrosis factor alpha mediates GABA<sub>A<\/sub> receptor trafficking to the plasma membrane of spinal cord neurons <i>in vivo<\/i>. Neural Plast. <b>2012<\/b>, 261345.","DOI":"10.1155\/2012\/261345"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Miyamoto, A., Wake, H., Ishikawa, A.W., Eto, K., Shibata, K., Murakoshi, H. <i>et al<\/i>. (2016) Microglia contact induces synapse formation in developing somatosensory cortex. Nat. Commun. <b>7<\/b>, 12540.","DOI":"10.1038\/ncomms12540"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71) Gallo, N.B., Berisha, A. and Van Aelst, L. (2022) Microglia regulate chandelier cell axo-axonic synaptogenesis. Proc. Natl. Acad. Sci. U.S.A. <b>119<\/b>, e2114476119.","DOI":"10.1073\/pnas.2114476119"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72) Rothstein, J.D., Martin, L., Levey, A.I., Dykes-Hoberg, M., Jin, L., Wu, D. <i>et al<\/i>. (1994) Localization of neuronal and glial glutamate transporters. Neuron <b>13<\/b>, 713-725.","DOI":"10.1016\/0896-6273(94)90038-8"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Chaudhry, F.A., Lehre, K.P., van Lookeren Campagne, M., Ottersen, O.P., Danbolt, N.C. and Storm-Mathisen, J. (1995) Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron <b>15<\/b>, 711-720.","DOI":"10.1016\/0896-6273(95)90158-2"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Yamada, K., Fukaya, M., Shibata, T., Kurihara, H., Tanaka, K., Inoue, Y. <i>et al<\/i>. (2000) Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth and synapse formation of cerebellar Purkinje cells. J. Comp. Neurol. <b>418<\/b>, 106-120.","DOI":"10.1002\/(SICI)1096-9861(20000228)418:1<106::AID-CNE8>3.0.CO;2-N"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75) Miyazaki, T., Yamasaki, M., Hashimoto, K., Kohda, K., Yuzaki, M., Shimamoto, K. <i>et al<\/i>. (2017) Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells. Proc. Natl. Acad. Sci. U.S.A. <b>114<\/b>, 7438-7443.","DOI":"10.1073\/pnas.1617330114"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Watase, K., Hashimoto, K., Kano, M., Yamada, K., Watanabe, M., Inoue, Y. <i>et al<\/i>. (1998) Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. European J. Neurosci. <b>10<\/b>, 976-988.","DOI":"10.1046\/j.1460-9568.1998.00108.x"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Iino, M., Goto, K., Kakegawa, W., Okado, H., Sudo, M., Ishiuchi, S. <i>et al<\/i>. (2001) Glia-synapse interaction through Ca<sup>2+<\/sup>-permeable AMPA receptors in Bergmann glia. Science <b>292<\/b>, 926-929.","DOI":"10.1126\/science.1058827"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78) Tsai, P.T., Hull, C., Chu, Y., Greene-Colozzi, E., Sadowski, A.R., Leech, J.M. <i>et al<\/i>. (2012) Autistic-like behaviour and cerebellar dysfunction in Purkinje cell <i>Tsc1<\/i> mutant mice. Nature <b>488<\/b>, 647-651.","DOI":"10.1038\/nature11310"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Amaral, D.G., Schumann, C.M. and Nordahl, C.W. (2008) Neuroanatomy of autism. Trends Neurosci. <b>31<\/b>, 137-145.","DOI":"10.1016\/j.tins.2007.12.005"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80) Stoodley, C.J., D&apos;Mello, A.M., Ellegood, J., Jakkamsetti, V., Liu, P., Nebel, M.B. <i>et al<\/i>. (2017) Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice. Nat. Neurosci. <b>20<\/b>, 1744-1751.","DOI":"10.1038\/s41593-017-0004-1"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81) Peter, S., Ten Brinke, M.M., Stedehouder, J., Reinelt, C.M., Wu, B., Zhou, H. <i>et al<\/i>. (2016) Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice. Nat. Commun. <b>7<\/b>, 12627.","DOI":"10.1038\/ncomms12627"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82) Cupolillo, D., Hoxha, E., Faralli, A., De Luca, A., Rossi, F., Tempia, F. <i>et al<\/i>. (2016) Autistic-like traits and cerebellar dysfunction in Purkinje cell PTEN knock-out mice. Neuropsychopharmacology <b>41<\/b>, 1457-1466.","DOI":"10.1038\/npp.2015.339"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83) Xu, F.X., Wang, X.T., Cai, X.Y., Liu, J.Y., Guo, J.W., Yang, F. <i>et al<\/i>. (2023) Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling. Cell Rep. <b>42<\/b>, 113559.","DOI":"10.1016\/j.celrep.2023.113559"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84) Takagishi, Y., Hashimoto, K., Kayahara, T., Watanabe, M., Otsuka, H., Mizoguchi, A. <i>et al<\/i>. (2007) Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. Dev. Neurobiol. <b>67<\/b>, 909-923.","DOI":"10.1002\/dneu.20375"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85) Hansel, C., de Jeu, M., Belmeguenai, A., Houtman, S.H., Buitendijk, G.H.H.S., Andreev, D. <i>et al<\/i>. (2006) \u03b1CaMKII is essential for cerebellar LTD and motor learning. Neuron <b>51<\/b>, 835-843.","DOI":"10.1016\/j.neuron.2006.08.013"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86) Ribar, T.J., Rodriguiz, R.M., Khiroug, L., Wetsel, W.C., Augustine, G.J. and Means, A.R. (2000) Cerebellar defects in Ca<sup>2+<\/sup>\/calmodulin kinase IV-deficient mice. J. Neurosci. <b>20<\/b>, RC107.","DOI":"10.1523\/JNEUROSCI.20-22-j0004.2000"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87) Iizuka, A., Matsuzaki, Y., Konno, A. and Hirai, H. (2016) Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR\u03b1. Brain Struct Funct. <b>221<\/b>, 2879-2889.","DOI":"10.1007\/s00429-015-1077-9"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88) Chen, X.R., Heck, N., Lohof, A.M., Rochefort, C., Morel, M.P., Wehrl\u00e9, R. <i>et al<\/i>. (2013) Mature Purkinje cells require the retinoic acid-related orphan receptor-\u03b1 (ror\u03b1) to maintain climbing fiber mono-innervation and other adult characteristics. J. Neurosci. <b>33<\/b>, 9546-9562.","DOI":"10.1523\/JNEUROSCI.2977-12.2013"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89) Kakizawa, S., Yamada, K., Iino, M., Watanabe, M. and Kano, M. (2003) Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development. Euro. J. Neurosci. <b>17<\/b>, 545-554.","DOI":"10.1046\/j.1460-9568.2003.02486.x"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90) Cornejo, F., Cort\u00e9s, B.I., Findlay, G.M. and Cancino, G.I. (2021) LAR receptor tyrosine phosphatase family in healthy and diseased brain. Front. Cell Dev. Biol. <b>9<\/b>, 659951.","DOI":"10.3389\/fcell.2021.659951"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91) Koekkoek, S.K.E., Yamaguchi, K., Milojkovic, B.A., Dortland, B.R., Ruigrok, T.J.H., Maex, R. <i>et al<\/i>. (2005) Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD., enlarges spines, and attenuates cerebellar eyelid conditioning in fragile X syndrome. Neuron <b>47<\/b>, 339-352.","DOI":"10.1016\/j.neuron.2005.07.005"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92) Gibson, J.M., Vazquez, A.H., Yamashiro, K., Jakkamsetti, V., Ren, C., Lei, K. <i>et al<\/i>. (2023) Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models. Cell Rep. <b>42<\/b>, 113533.","DOI":"10.1016\/j.celrep.2023.113533"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93) Bedogni, F., Hodge, R.D., Nelson, B.R., Frederick, E.A., Shiba, N., Daza, R.A. <i>et al<\/i>. (2010) <i>Autism susceptibility candidate 2 (Auts2)<\/i> encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology. Gene Expr. Patterns <b>10<\/b>, 9.","DOI":"10.1016\/j.gep.2009.11.005"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94) Yamashiro, K., Hori, K., Lai, E.S.K., Aoki, R., Shimaoka, K., Arimura, N. <i>et al<\/i>. (2020) AUTS2 governs cerebellar development, Purkinje cell maturation, motor function and social communication. iScience <b>23<\/b>, 101820.","DOI":"10.1016\/j.isci.2020.101820"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95) Tabuchi, K., Blundell, J., Etherton, M.R., Hammer, R.E., Liu, X., Powell, C.M. <i>et al<\/i>. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science <b>318<\/b>, 71-76.","DOI":"10.1126\/science.1146221"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96) Rothwell, P.E., Fuccillo, M.V., Maxeiner, S., Hayton, S.J., Gokce, O., Lim, B.K. <i>et al<\/i>. (2014) Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors. Cell <b>158<\/b>, 198-212.","DOI":"10.1016\/j.cell.2014.04.045"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97) Lai, E.S.K., Nakayama, H., Miyazaki, T., Nakazawa, T., Tabuchi, K., Hashimoto, K. <i>et al<\/i>. (2021) An autism-associated neuroligin-3 mutation affects developmental synapse elimination in the cerebellum. Front. Neural Circuits. <b>15<\/b>, 676891.","DOI":"10.3389\/fncir.2021.676891"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98) Piochon, C., Kloth, A.D., Grasselli, G., Titley, H.K., Nakayama, H., Hashimoto, K. <i>et al<\/i>. (2014) Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nat. Commun. <b>5<\/b>, 5586.","DOI":"10.1038\/ncomms6586"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99) Nakatani, J., Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K. <i>et al<\/i>. (2009) Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell <b>137<\/b>, 1235-1246.","DOI":"10.1016\/j.cell.2009.04.024"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100) Simmons, D.H., Busch, S.E., Titley, H.K., Grasselli, G., Shih, J., Du, X. <i>et al<\/i>. (2022) Sensory over-responsivity and aberrant plasticity in cerebellar cortex in a mouse model of syndromic autism. Biol. Psychiatry Global Open Sci. <b>2<\/b>, 450-459.","DOI":"10.1016\/j.bpsgos.2021.09.004"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101) Kelly, E., Meng, F., Fujita, H., Morgado, F., Kazemi, Y., Rice, L.C. <i>et al<\/i>. (2020) Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits. Nat. Neurosci. <b>23<\/b>, 1102-1110.","DOI":"10.1038\/s41593-020-0665-z"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102) Fujimoto, S., Leiwe, M.N., Aihara, S., Sakaguchi, R., Muroyama, Y., Kobayakawa, R. <i>et al<\/i>. (2023) Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice. Dev. Cell. <b>58<\/b>, 1221-1236.e7.","DOI":"10.1016\/j.devcel.2023.05.004"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103) Smith, I.W., Mikesh, M., Lee, Y.i. and Thompson, W.J. (2013) Terminal Schwann cells participate in the competition underlying neuromuscular synapse elimination. J. Neurosci. <b>33<\/b>, 17724-17736.","DOI":"10.1523\/JNEUROSCI.3339-13.2013"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104) Song, J.W., Misgeld, T., Kang, H., Knecht, S., Lu, J., Cao, Y. <i>et al<\/i>. (2008) Lysosomal activity associated with developmental axon pruning. J. Neurosci. <b>28<\/b>, 8993-9001.","DOI":"10.1523\/JNEUROSCI.0720-08.2008"},{"key":"105","doi-asserted-by":"crossref","unstructured":"105) Bravin, M., Morando, L., Vercelli, A., Rossi, F. and Strata, P. (1999) Control of spine formation by electrical activity in the adult rat cerebellum. Proc. Natl. Acad. Sci. U.S.A. <b>96<\/b>, 1704-1709.","DOI":"10.1073\/pnas.96.4.1704"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106) Kakizawa, S., Miyazaki, T., Yanagihara, D., Iino, M., Watanabe, M. and Kano, M. (2005) Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. Proc. Natl. Acad. Sci. U.S.A. <b>102<\/b>, 19180-19185.","DOI":"10.1073\/pnas.0504359103"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107) Zhou, H., Lin, Z., Voges, K., Ju, C., Gao, Z., Bosman, L.W.J. <i>et al<\/i>. (2014) Cerebellar modules operate at different frequencies. eLife <b>3<\/b>, e02536.","DOI":"10.7554\/eLife.02536"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108) Kozareva, V., Martin, C., Osorno, T., Rudolph, S., Guo, C., Vanderburg, C. <i>et al<\/i>. (2021) A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types. Nature. <b>598<\/b>, 214-219.","DOI":"10.1038\/s41586-021-03220-z"}],"container-title":["Proceedings of the Japan Academy, Series B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/pjab\/100\/9\/100_pjab.100.034\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T04:28:32Z","timestamp":1731731312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/pjab\/100\/9\/100_pjab.100.034\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":108,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2183\/pjab.100.034","relation":{},"ISSN":["0386-2208","1349-2896"],"issn-type":[{"value":"0386-2208","type":"print"},{"value":"1349-2896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"pjab.100.034"}}