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(2001) Autoimmune disease: why and where it occurs. Nat. Med. <b>7<\/b>, 899&ndash;905.","DOI":"10.1038\/90935"},{"key":"2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ni0901-759","volume":"2","author":"Ermann, J. and Fathman, C.G.","year":"2001","journal-title":"Nat. Immunol.","ISSN":"https:\/\/id.crossref.org\/issn\/1529-2908","issn-type":"print"},{"key":"3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nri702","volume":"2","author":"O&rsquo;Shea, J.J., Ma, A. and","year":"2002","journal-title":"Nat. Rev. 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Immunol.","ISSN":"https:\/\/id.crossref.org\/issn\/0883-0185","issn-type":"print"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5445.1732"},{"key":"9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1359-6101(02)00017-5","volume":"13","author":"Hirano, T.","year":"2002","journal-title":"Cytokine Growth Factor Rev.","ISSN":"https:\/\/id.crossref.org\/issn\/1359-6101","issn-type":"print"},{"key":"10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/ni0402-342","volume":"3","author":"Hirano, T.","year":"2002","journal-title":"Nat. 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Dis.","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4967","issn-type":"print"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.03.005"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020619"},{"key":"19","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1084\/jem.20052187","volume":"12","author":"Sawa, S., Kamimura, D., Jin, G.H.,","year":"2006","journal-title":"J. Exp. Med.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1007","issn-type":"print"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421795"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.4.461"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8222"},{"key":"23","first-page":"2","volume":"2004","author":"Murakami, M., Kamimura, D. and Hira","year":"2004","journal-title":"Growth Factors","ISSN":"https:\/\/id.crossref.org\/issn\/0897-7194","issn-type":"print"},{"key":"24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10254-003-0012-2","volume":"149","author":"Kamimura, D., Ishihara, K. and Hira","year":"2003","journal-title":"Rev. Physiol. Biochem. Pharmacol.","ISSN":"https:\/\/id.crossref.org\/issn\/0303-4240","issn-type":"print"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80501-4"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80162-4"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/nature01355"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Nishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F. <i>et&nbsp;al.<\/i> (2007) IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int. Immunol. <b>19<\/b>, 695&ndash;702.","DOI":"10.1093\/intimm\/dxm045"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Linterman, M.A. and Vinuesa, C.G. (2010) Signals that influence T follicular helper cell differentiation and function. Semin. Immunopathol. (in press).","DOI":"10.1007\/s00281-009-0194-z"},{"key":"36","first-page":"355","volume":"1","author":"Dutton, R.W., Falkoff, R., Hirst, J","year":"1971","journal-title":"Pro. Immunol.","ISSN":"https:\/\/id.crossref.org\/issn\/0019-2805","issn-type":"print"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Schimpl, A. and Wecker, E. (1972) Replacement of T cell function by a T cell product. Nat. New Biol. <b>235<\/b>, 15&ndash;17.","DOI":"10.1038\/newbio237015a0"},{"key":"38","unstructured":"38) Hirano, T., Teranishi, T., Toba, T., Sakaguchi, N., Fukukawa, T. and Tsuyuguchi, I. (1981) Human helper T cell factor(s) (ThF). I. Partial purification and characterization. J. Immunol. <b>126<\/b>, 517&ndash;522."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Muraguchi, A., Kishimoto, T., Miki, Y., Kuritani, T., Kaieda, T., Yoshizaki, K. <i>et&nbsp;al.<\/i> (1981) T cell-replacing factor(TRF)-induced IgG secretion in human B blastoid cell line and demonstration of acceptors for TRF. J. Immunol. <b>127<\/b>, 412&ndash;416.","DOI":"10.4049\/jimmunol.127.2.412"},{"key":"40","unstructured":"40) Teranishi, T., Hirano, T., Arima, N. and Onoue, K. (1982) Human helper T cell factor(s) (ThF). II. Induction of IgG production in B lymphoblastoid cell lines and identification of T cell replacing factor (TRF)-like factor(s). J. Immunol. <b>128<\/b>, 1903&ndash;1908."},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.2.583"},{"key":"42","unstructured":"42) Hirano, T., Teranishi, T. and Onoue, K. (1984) Human helper T cell factor(s). III. Characterization of B cell differentiation factor I (BCDF I). J. Immunol. <b>132<\/b>, 229&ndash;234."},{"key":"43","unstructured":"43) Hirano, T., Teranishi, T., Lin, B. and Onoue, K. (1984) Human helper T cell factor(s). IV. Demonstration of a human late-acting B cell differentiation factor acting on Staphylococcus aureus Cowan I-stimulated B cells. J. Immunol. <b>133<\/b>, 798&ndash;802."},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.16.5490"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.1.228"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1038\/324073a0"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1986.tb09931.x"},{"issue":"10","key":"48","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1002\/j.1460-2075.1986.tb04531.x","volume":"5","year":"1986","journal-title":"EMBO J.","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"key":"49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1126\/science.3276001","volume":"239","author":"Marx, J.L.","year":"1988","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.3492764","volume":"235","author":"Sehgal, P.B., May, T.T., Tamm, I. a","year":"1987","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80344-7"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7251"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.914"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1038\/332083a0"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180202"},{"key":"56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1989.tb23994.x","volume":"557","author":"Sehgal, P.B., Grienger, G. and Tosa","year":"1989","journal-title":"Ann. New York Acad. Sci.","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1038\/319640a0"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1038\/324070a0"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Hirano, T. and Kishimoto, T. (1990) Interleukin-6. Handbook of Experimental Pharmacology <b>95\/I<\/b>, 633&ndash;665.","DOI":"10.1007\/978-3-642-49295-2_14"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.8.1.253"},{"issue":"3","key":"61","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2650621","volume":"265","year":"1990","journal-title":"Biochem. J.","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1126\/science.3136546"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90411-7"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90438-8"},{"key":"65","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/0090-1229(92)90042-M","volume":"62","author":"Hirano, T.","year":"1992","journal-title":"Clin. Immunol. 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(2006) GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. Cell Res. <b>16<\/b>, 3&ndash;10.","DOI":"10.1038\/sj.cr.7310002"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.7.1.145"},{"issue":"14","key":"70","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1101\/gad.14.14.1693","volume":"14","author":"GLIMCHER L H","year":"2000","journal-title":"Genes Dev.","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28508"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062259"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-345"},{"key":"74","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2249.2007.03356.x","volume":"148","author":"Afzali, B., Lombardi, G., Lechler,","year":"2007","journal-title":"Clin. Exp. 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