{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:40:04Z","timestamp":1787658004672,"version":"build-2736575974"},"reference-count":87,"publisher":"Japan Academy","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. Jpn. Acad., Ser. B","Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences"],"published-print":{"date-parts":[[2012]]},"DOI":"10.2183\/pjab.88.152","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T03:57:50Z","timestamp":1334116670000},"page":"152-166","source":"Crossref","is-referenced-by-count":52,"title":["Antimicrobial peptide defensin: Identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases"],"prefix":"10.2183","volume":"88","author":[{"given":"Yasuhiro","family":"YAMAGUCHI","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"OUCHI","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"993","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.284.5418.1313","volume":"284","author":"Hoffmann, J.A., Kafatos, F.C., Jane","year":"1999","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Strominger, J.L. (2009) Animal antimicrobial peptides: ancient players in innate immunity. J. Immunol. <b>182<\/b>, 6633&ndash;6634.","DOI":"10.4049\/jimmunol.0990038"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/292246a0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.15.5449"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112120"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.9.3952"},{"issue":"9","key":"7","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1016\/S0021-9258(18)53298-1","volume":"268","year":"1993","journal-title":"J. Biol. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.498"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1022-4"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00687-5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1861"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)01123-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63574-X"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/43088"},{"key":"15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1172\/JCI2410","volume":"102","author":"Bals, R., Wang, X., Wu, Z., Freeman","year":"1998","journal-title":"J. Clin. Invest.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008557200"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00569-2"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s004410100433"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00875-2"},{"key":"20","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1128\/IAI.66.3.1225-1232.1998","volume":"66","author":"Bals, R., Goldman, M.J. and Wilson,","year":"1998","journal-title":"Infect. Immun.","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01630-5"},{"key":"22","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1128\/IAI.67.7.3542-3547.1999","volume":"67","author":"Bals, R., Wang, X., Meegalla, R.L.,","year":"1999","journal-title":"Infect. Immun.","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006603200"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00136-5"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104149200"},{"key":"26","unstructured":"26) Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H. and Ouchi, Y. (2002) Identification of multiple novel epididymis-specific &beta;-defensin isoforms in humans and mice. J. Immunol. <b>169<\/b>, 2516&ndash;2523."},{"key":"27","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1096\/fj.00-0865fje","volume":"15","author":"Garc&iacute;a, J.R., Krause, A.","year":"2001","journal-title":"FASEB J.","ISSN":"https:\/\/id.crossref.org\/issn\/0892-6638","issn-type":"print"},{"key":"28","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1128\/AAC.01308-07","volume":"52","author":"Hinrichsen, K., Podschun, R., Schub","year":"2008","journal-title":"Antimicrob. Agents Chemother.","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042692699"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1038\/nature05329"},{"key":"31","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1101\/gr.080945.108","volume":"18","author":"Hollox, E.J., Barber, J.C., Brookes","year":"2008","journal-title":"Genome Res.","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00996-10"},{"key":"33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/1471-2164-10-606","volume":"10","author":"Amid, C., Rehaume, L.M., Brown, K.L","year":"2009","journal-title":"BMC Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2164","issn-type":"print"},{"key":"34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1042\/bst0290598","volume":"29","author":"Matsuzaki, K.","year":"2001","journal-title":"Biochem. Soc. Trans.","ISSN":"https:\/\/id.crossref.org\/issn\/0300-5127","issn-type":"print"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00688-09"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.03.004"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1039\/c1np00022e"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/nature09674"},{"key":"39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1440-1843.2002.00415.x","volume":"7","author":"Tomita, T., Nagase, T., Ohga, E., Y","year":"2002","journal-title":"Respirology","ISSN":"https:\/\/id.crossref.org\/issn\/1323-7799","issn-type":"print"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14961"},{"key":"41","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1165\/ajrcmb.22.6.4023","volume":"22","author":"Harder, J., Meyer-Hoffert, U., Tera","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol.","ISSN":"https:\/\/id.crossref.org\/issn\/1044-1549","issn-type":"print"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.10.5750-5758.2004"},{"key":"43","doi-asserted-by":"crossref","first-page":"L687","DOI":"10.1152\/ajplung.00365.2009","volume":"298","author":"Scharf, S., Hippenstiel, S., Fliege","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol.","ISSN":"https:\/\/id.crossref.org\/issn\/1040-0605","issn-type":"print"},{"key":"44","unstructured":"44) Albanesi, C., Fairchild, H.R., Madonna, S., Scarponi, C., De Pita, O., Leung, D.Y. and Howell, M.D. (2007) IL-4 and IL-13 negatively regulate TNF-&alpha;- and IFN&gamma;-induced &beta;-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J. Immunol. <b>179<\/b>, 984&ndash;992."},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.525"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075565"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702130104"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737292"},{"key":"49","unstructured":"49) R&ouml;hrl, J., Yang, D., Oppenheim, J.J. and Hehlgans, T. (2010) Human &beta;-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. J. Immunol. <b>184<\/b>, 6688&ndash;6694."},{"key":"50","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1182\/blood-2005-06-2314","volume":"107","author":"Khine, A.A., Del Sorbo, L., Vaschet","year":"2006","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"51","unstructured":"51) Niyonsaba, F., Iwabuchi, K., Matsuda, H., Ogawa, H. and Nagaoka, I. (2002) Epithelial cell-derived human &beta;-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway. Int. Immunol. <b>14<\/b>, 421&ndash;426."},{"key":"52","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1128\/AAC.50.4.1433-1441.2006","volume":"50","author":"Boniotto, M., Jordan, W.J., Eskdale","year":"2006","journal-title":"Antimicrob. Agents Chemother.","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"53","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1098\/rspb.1922.0023","volume":"93","author":"Fleming, A.","year":"1922","journal-title":"Proc. R. Soc. Lond., B, Biol. Sci.","ISSN":"https:\/\/id.crossref.org\/issn\/0080-4649","issn-type":"print"},{"key":"54","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1128\/IAI.67.7.3267-3275.1999","volume":"67","author":"Cole, A.M., Dewan, P. and Ganz, T.","year":"1999","journal-title":"Infect. Immun.","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1038\/35106587"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5437.113"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1038\/nature01520"},{"key":"58","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1128\/IAI.70.6.3068-3072.2002","volume":"70","author":"Moser, C., Weiner, D.J., Lysenko, E","year":"2002","journal-title":"Infect. Immun.","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"59","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1128\/IAI.70.6.3053-3060.2002","volume":"70","author":"Morrison, G., Kilanowski, F., David","year":"2002","journal-title":"Infect. Immun.","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1825"},{"key":"61","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1095\/biolreprod50.3.516","volume":"50","author":"Osterhoff, C., Kirchhoff, C., Krull","year":"1994","journal-title":"Biol. Reprod.","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3363","issn-type":"print"},{"key":"62","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1210\/en.141.3.1245","volume":"141","author":"Hamil, K.G., Sivashanmugam, P., Ric","year":"2000","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"63","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1095\/biolreprod64.4.1072","volume":"64","author":"Fr&ouml;hlich, O., Po, C. and Y","year":"2001","journal-title":"Biol. Reprod.","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3363","issn-type":"print"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1126\/science.1056545"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.057323"},{"key":"66","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/gb-2003-4-5-r31","volume":"4","author":"Semple, C.A., Rolfe, M. and Dorin,","year":"2003","journal-title":"Genome Biol.","ISSN":"https:\/\/id.crossref.org\/issn\/1465-6906","issn-type":"print"},{"key":"67","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1465-9921-6-130","volume":"6","author":"Yanagi, S., Ashitani, J., Ishimoto,","year":"2005","journal-title":"Respir. Res.","ISSN":"https:\/\/id.crossref.org\/issn\/1465-9921","issn-type":"print"},{"key":"68","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2362.2008.02071.x","volume":"39","author":"Otte, J.M., Neumann, H.M., Brand, S","year":"2009","journal-title":"Eur. J. Clin. Invest.","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2972","issn-type":"print"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23234.x"},{"key":"70","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1210\/en.142.10.4529","volume":"142","author":"Liu, Q., Hamil, K.G., Sivashanmugam","year":"2001","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"71","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0888-7543(02)00034-4","volume":"81","author":"Rodr&iacute;guez-Jim&eacute","year":"2003","journal-title":"Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/0888-7543","issn-type":"print"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1127"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Xu, W., Zhang, X., Chen, W., Fok, K.L., Rowlands, D.K., Chui, Y.L. and Chan, H.C. (2010) Immunization with Bin1b decreases sperm motility with compromised fertility in rats. Fertil. Steril. <b>93<\/b>, 952&ndash;958.","DOI":"10.1016\/j.fertnstert.2008.10.066"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.107.064071"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75) Tollner, T.L., Yudin, A.I., Treece, C.A., Overstreet, J.W. and Cherr, G.N. (2008) Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus. Hum. Reprod. <b>23<\/b>, 2523&ndash;2534.","DOI":"10.1093\/humrep\/den276"},{"key":"76","doi-asserted-by":"crossref","first-page":"92ra65","DOI":"10.1126\/scitranslmed.3002289","volume":"3","author":"Tollner, T.L., Venners, S.A., Hollo","year":"2011","journal-title":"Sci. Transl. Med.","ISSN":"https:\/\/id.crossref.org\/issn\/1946-6234","issn-type":"print"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.01.028"},{"key":"78","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1002\/pmic.200401180","volume":"5","author":"Merkel, D., Rist, W., Seither, P.,","year":"2005","journal-title":"Proteomics","ISSN":"https:\/\/id.crossref.org\/issn\/1615-9853","issn-type":"print"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Konishi, K., Gibson, K.F., Lindell, K.O., Richards, T.J., Zhang, Y., Dhir, R., Bisceglia, M., Gilbert, S., Yousem, S.A., Song, J.W., Kim, D.S. and Kaminski, N. (2009) Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. <b>180<\/b>, 167&ndash;175.","DOI":"10.1164\/rccm.200810-1596OC"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115310"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(91)90136-Y"},{"key":"82","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0140-6736(98)04648-0","volume":"353","author":"Sawicki, W. and Mystkowska, E.T.","year":"1999","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"83","doi-asserted-by":"crossref","first-page":"C2141","DOI":"10.1152\/ajpcell.00295.2006","volume":"292","author":"Yamaguchi, Y., Nagase, T., Tomita,","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol.","ISSN":"https:\/\/id.crossref.org\/issn\/0363-6143","issn-type":"print"},{"key":"84","unstructured":"84) Bdeir, K., Higazi, A.A., Kulikovskaya, I., Christofidou-Solomidou, M., Vinogradov, S.A., Allen, T.C., Idell, S., Linzmeier, R., Ganz, T. and Cines, D.B. (2010) Neutrophil &alpha;-defensins cause lung injury by disrupting the capillary-epithelial barrier. Am. J. Respir. Crit. Care Med. <b>181<\/b>, 935&ndash;946."},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181d968eb"},{"key":"86","unstructured":"86) Janssens, W., Nuytten, H., Dupont, L.J., Van Eldere, J., Vermeire, S., Lambrechts, D., Nackaerts, K., Decramer, M., Cassiman, J.J. and Cuppens, H. (2010) Genomic copy number determines functional expression of &beta;-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. <b>182<\/b>, 163&ndash;169."},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.48"}],"container-title":["Proceedings of the Japan Academy, Series B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/pjab\/88\/4\/88_4_152\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T16:35:39Z","timestamp":1642005339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/pjab\/88\/4\/88_4_152\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":87,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2183\/pjab.88.152","relation":{},"ISSN":["0386-2208","1349-2896"],"issn-type":[{"value":"0386-2208","type":"print"},{"value":"1349-2896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}