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(2007) Vacuolar ATPases: Rotatory proton pumps in physiology and pathophysiology. Nat. Rev. Mol. Cell Biol. 11, 917\u2013929."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Okamoto, H. and Futai, M. (2018) Vacuolar-type ATPases in animal and plant cells. <i>In<\/i> Encyclopedia of Biophysics (eds. Roberts, G., Watts, A. and European Biophysical Societies). Springer, Berlin,  Heidelberg, pp. 2\u20138.","DOI":"10.1007\/978-3-642-35943-9_203-1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Sun-Wada, G.H., Wada, Y. and Futai, M. (2004) Diverse and essential roles of mammalian vacuolar-type proton pump ATPase: Toward the physiological understanding of inside acidic compartments. Biochim. Biophys. Acta 1658, 106\u2013114.","DOI":"10.1016\/j.bbabio.2004.04.013"},{"key":"4","unstructured":"4) Marshansky, V. and Futai, M. (2008) The V-type H<sup>+<\/sup>-ATPase in vesicular trafficking: Targeting, regulation and function. Curr. Opin. Cell Biol. 20, 415\u2013426."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Marshansky, V., Futai, M. and Gr\u00fcber, G. (2016) Eukaryotic V-ATPase and its super-complexes: From structure and function to disease and drug targeting. <i>In<\/i> Regulation of Ca2<sup>+<\/sup>-ATPases, V-ATPases and F-ATPases (eds. Chakraborti, S. and Dhalla, N.). Advances in Biochemistry in Health and Disease, Vol. 14, Springer, New York, pp. 301\u2013335.","DOI":"10.1007\/978-3-319-24780-9_16"},{"key":"6","unstructured":"6) Pamarthy, S., Kulshrestha, A., Katara, G.K. and Beaman, K.D. (2018) The curious case of vacuolar ATPase: Regulation of signaling pathways. Mol. Cancer 17, 41."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Toei, M., Saum, R. and Forgac, M. (2010) Regulation and isoform function of the V-ATPases. Biochemistry 49, 4715\u20134723.","DOI":"10.1021\/bi100397s"},{"key":"8","unstructured":"8) Futai, M., Nakanishi-Matsui, M., Okamoto, H., Sekiya, M. and Nakamoto, B.K. (2012) Rotational catalysis in proton pump ATPases: From <i>E. coli<\/i> F-ATPase to mammalian V-ATPase. Biochim. Biophys. Acta 1817, 1711\u20131721."},{"key":"9","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/15216540600702255","volume":"58","author":"M. Nakanishi-Matsui","year":"2006","unstructured":"9) Nakanishi-Matsui, M. and Futai, M. (2006) Stochastic proton pumping ATPases: From single molecules to diverse physiological roles. IUBMB Life 58, 318\u2013322.","journal-title":"IUBMB Life","ISSN":"https:\/\/id.crossref.org\/issn\/1521-6543","issn-type":"print"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Futai, M., Noumi, T. and Maeda, M. (1989) ATP synthase (H<sup>+<\/sup>-ATPase): Results by combined biochemical and molecular biological approaches. Annu. Rev. Biochem. 58, 111\u2013136.","DOI":"10.1146\/annurev.bi.58.070189.000551"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Boyer, P.D. (1997) The ATP synthase \u2014 A splendid molecular machine. Annu. Rev. Biochem. 66, 717\u2013749.","DOI":"10.1146\/annurev.biochem.66.1.717"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Futai, M., Wada, Y. and Kaplan, J.H. (2005) Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology. Wiley-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.","DOI":"10.1002\/3527606122"},{"key":"13","unstructured":"13) Hanada, H., Moriyama, Y., Maeda, M. and Futai, M. (1990) Kinetic studies of chromaffin granule H<sup>+<\/sup>-ATPase and effects of bafilomycin. Biochem. Biophys. Res. Commun. 170, 873\u2013878."},{"key":"14","unstructured":"14) Roh, S.H., Stam, N.J., Hryc, C.F., Couoh-Cardel, S., Pintilie, G., Chiu, W.  (2018) The 3.5-\u00c5 CryoEM structure of nanodisc-reconstituted yeast vacuolar ATPase V<sub>o<\/sub> proton channel. Mol. Cell 69, 993\u20131018."},{"key":"15","unstructured":"15) Toei, M. and Forgac, M. (2011) Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase. J. Biol. Chem. 286, 35176\u201335186."},{"key":"16","unstructured":"16) Schep, D.G., Zhao, J. and Rubinstein, J.L. (2016) Models for the a subunits of the <i>Thermus thermophilus<\/i> V\/A-ATPase and <i>Saccharomyces cerevisiae<\/i> V-ATPase enzymes by cryo-EM and evolutionary covariance. Proc. Natl. Acad. Sci. U.S.A. 113, 3245\u20133250."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Mazhab-Jafari, M.T., Rohou, A., Schmidt, C., Bueler, S.A., Benlekbir, S., Robinson, C.V.  (2016) Atomic model for the membrane-embedded V<sub>O<\/sub> motor of a eukaryotic V-ATPase. Nature 539, 118\u2013122.","DOI":"10.1038\/nature19828"},{"key":"18","unstructured":"18) Nelson, H. and Nelson, N. (1990) Disruption of genes encoding subunits of yeast vacuolar H<sup>+<\/sup> ATPase cause conditional lethality. Proc. Natl. Acad. Sci. U.S.A. 87, 3503\u20133507."},{"key":"19","unstructured":"19) Umemoto, N., Yoshihisa, T., Hirata, R. and Anraku, Y. (1990) Roles of the <i>VMA3<\/i> gene product, subunit <i>c<\/i> of the vacuolar membrane H<sup>+<\/sup>-ATPase on vacuolar acidification and protein transport. A study with VMA3-disrupted mutants of <i>Saccharomyces cerevisiae<\/i>. J. Biol. Chem. 265, 18447\u201318453."},{"key":"20","unstructured":"20) Oka, T., Yamamoto, R. and Futai, M. (1997) Three <i>vha<\/i> genes encode proteolipids of <i>Caenorhabditis elegans<\/i> vacuolar-type ATPase: Gene structures and preferential expression in an H-shaped excretory cell and rectal cells. J. Biol. Chem. 272, 24387\u201324392."},{"key":"21","unstructured":"21) Smith, A.N., Lovering, R.C., Futai, M., Takeda, J., Brown, D. and Karet, F.E. (2003) Revised nomenclature for mammalian vacuolar-type H<sup>+<\/sup>-ATPase subunit genes. Mol. Cell 12, 801\u2013803."},{"key":"22","unstructured":"22) Bowman, E.J., Graham, L.A., Stevens, T.H. and Bowman, B.J. (2004) The bafilomycin\/concanamycin binding site in subunit c of the V-ATPases from <i>Neurospora crassa<\/i> and <i>Saccharomyces cerevisiae<\/i>. J. Biol. Chem. 279, 33131\u201333138."},{"key":"23","unstructured":"23) Moriyama, Y. and Futai, M. (1990) H<sup>+<\/sup>-ATPase, a primary pump for accumulation of neurotransmitters, is a major constituent of brain synaptic vesicles. Biochem. Biophys. Res. Commun. 173, 443\u2013446."},{"key":"24","unstructured":"24) Moriyama, Y., Maeda, M. and Futai, M. (1992) The role of V-ATPase in neural and endocrine systems. J. Exp. Biol. 172, 171\u2013178."},{"key":"25","unstructured":"25) Moriyama, Y. and Futai, M. (1990) Presence of 5-hydroxytryptamine (serotonin) transport coupled with vacuolar-type H<sup>+<\/sup>-ATPase in neurosecretory granules from bovine posterior pituitary. J. Biol. Chem. 265, 9165\u20139169."},{"key":"26","unstructured":"26) Moriyama, Y., Yamamoto, A., Tashiro, Y., Tomochika, K.I., Takahashi, H., Maeda, M.  (1995) Microvesicles isolated from bovine posterior pituitary accumulate norepinephrine. J. Biol. Chem. 270, 11424\u201311429."},{"key":"27","doi-asserted-by":"publisher","unstructured":"27) Sambongi, Y., Iko, Y., Tanabe, M., Omote, H., Iwamoto-Kihara, A., Ueda, I.  (1999) Mechanical rotation of the <i>c<\/i> subunit oligomer in ATP synthase (F<sub>o<\/sub>F<sub>1<\/sub>): Direct observation. Science 286, 1722\u20131724.","DOI":"10.1126\/science.286.5445.1722"},{"key":"28","unstructured":"28) Omote, H., Sambonmatsu, N., Saito, K., Sambongi, Y., Iwamoto-Kihara, A., Yanagida, T.  (1999) The \u03b3-subunit rotation and torque generation in F<sub>1<\/sub>-ATPase from wild-type or uncoupled mutant <i>Escherichia coli<\/i>. Proc. Natl. Acad. Sci. U.S.A. 96, 7780\u20137784."},{"key":"29","unstructured":"29) Tanabe, M., Nishio, K., Iko, Y., Sambongi, Y., Iwamoto-Kihara, A., Wada, Y.  (2001) Rotation of a complex of the \u03b3 subunit and <i>c<\/i> ring of <i>Escherichia coli<\/i> ATP synthase: The rotor and stator are interchangeable. J. Biol. Chem. 276, 15269\u201315274."},{"key":"30","unstructured":"30) Nishio, K., Iwamoto-Kihara, A., Yamamoto, A., Wada, Y. and Futai, M. (2002) Subunit rotation of ATP synthase embedded in membranes: <i>a<\/i> or \u03b2 subunit rotation relative to the <i>c<\/i> subunit ring. Proc. Natl. Acad. Sci. U.S.A. 99, 13448\u201313452."},{"key":"31","unstructured":"31) Hirata, T., Iwamoto-Kihara, A., Sun-Wada, G.H., Okajima, T., Wada, Y. and Futai, M. (2003) Subunit rotation of vacuolar-type proton pumping ATPase: Relative rotation of the <i>G<\/i> and <i>c<\/i> subunits. J. Biol. Chem. 278, 23714\u201323719."},{"key":"32","unstructured":"32) Hirata, T., Nakamura, N., Omote, H., Wada, Y. and Futai, M. (2000) Regulation and reversibility of vacuolar H<sup>+<\/sup>-ATPase. J. Biol. Chem. 275, 386\u2013389."},{"key":"33","unstructured":"33) Gr\u00fcber, G., Manimekalai, M.S., Mayer, F. and M\u00fcller, V. (2014) ATP synthases from archaea: The beauty of a molecular motor. Biochim. Biophys. Acta 1837, 940\u2013952."},{"key":"34","unstructured":"34) Oka, T. and Futai, M. (2000) Requirement of V-ATPase for ovulation and embryogenesis in <i>Caenorhabditis elegans<\/i>. J. Biol. Chem. 275, 29556\u201329561."},{"key":"35","unstructured":"35) Yoshimori, T., Yamamoto, A., Moriyama, Y., Futai, M. and Tashiro, Y. (1991) Bafilomycin A1, a specific inhibitor of vacuolar-type H<sup>+<\/sup>-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J. Biol. Chem. 266, 17707\u201317712."},{"key":"36","unstructured":"36) Sun-Wada, G.H., Murata, Y., Yamamoto, A., Kanazawa, H., Wada, Y. and Futai, M. (2000) Acidic endomembrane organelles are required for mouse postimplantation development. Dev. Biol. 228, 315\u2013325."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Gaxiola, R.A., Palmgren, M.G. and Schumacher, K. (2007) Plant proton pumps. FEBS Lett. 581, 2204\u20132214.","DOI":"10.1016\/j.febslet.2007.03.050"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Graham, L.A., Fennigan, G.C. and Kane, P.M. (2018) Some assembly required: Contributions of Tom Stevens\u2019 lab to the V-ATPase field. Traffic 19, 385\u2013390.","DOI":"10.1111\/tra.12559"},{"key":"39","unstructured":"39) Banerjee, S. and Kane, P.M. (2017) Direct interaction of the Golgi V-ATPase a subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast. Mol. Biol. Cell 28, 2518\u20132530."},{"key":"40","unstructured":"40) Oka, T., Toyomura, T., Honjo, K., Wada, Y. and Futai, M. (2001) Four subunit <i>a<\/i> isoforms of <i>Caenorhabditis elegans<\/i> vacuolar H<sup>+<\/sup>-ATPase: Cell specific expression during development. J. Biol. Chem. 276, 33079\u201333085."},{"key":"41","unstructured":"41) Toyomura, T., Oka, T., Yamaguchi, C., Wada, Y. and Futai, M. (2000) Three subunit <i>a<\/i> isoforms of mouse vacuolar H<sup>+<\/sup>-ATPase: Preferential expression of the <i>a<\/i>3 isoforms during osteoclast differentiation. J. Biol. Chem. 275, 8760\u20138765."},{"key":"42","unstructured":"42) Oka, T., Murata, Y., Namba, M., Yoshimizu, T., Toyomura, T., Yamamoto, A.  (2001) <i>a<\/i>4, a unique kidney-specific isoform of mouse vacuolar H<sup>+<\/sup>-ATPase subunit <i>a<\/i>. J. Biol. Chem. 276, 40050\u201340054."},{"key":"43","unstructured":"43) Toyomura, T., Murata, Y., Yamamoto, A., Oka, T., Sun-Wada, G.H., Wada, Y.  (2003) From lysosomes to the plasma membrane: Localization of vacuolar type H<sup>+<\/sup>-ATPase with the <i>a<\/i>3 isoform during osteoclast differentiation. J. Biol. Chem. 278, 22023\u201322030."},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Hiesinger, P.R., Fayyazuddin, A., Mehta, S.Q., Rosenmund, T., Schulze, K.L., Zhai, R.G.  (2005) The v-ATPase V<sub>0<\/sub> subunit a1 is required for a late step in synaptic vesicle exocytosis in <i>Drosophila<\/i>. Cell 121, 607\u2013620.","DOI":"10.1016\/j.cell.2005.03.012"},{"key":"45","unstructured":"45) Kornak, U., Reynders, E., Dimopoulou, A., van Reeuwijk, J., Fischer, B., Rajab, A.  (2008) Impaired glycosylation and cutis laxa caused by mutations in the vesicular H<sup>+<\/sup>-ATPase subunit ATP6V0A2. Nat. Genet. 40, 32\u201334."},{"key":"46","unstructured":"46) Stover, E.H., Borthwick, K.J., Bavalia, C., Eady, N., Fritz, D.M., Rungroj, N.  (2002) Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. J. Med. Genet. 39, 796\u2013803."},{"key":"47","unstructured":"47) Esmail, S., Kartner, N., Joo, Y., Kim, J.W., Reithmeier, R.A.F. and Manolson, M.F. (2018) Molecular mechanisms of cutis laxa and distal renal tubular acidosis-causing mutations in V-ATPase <i>a<\/i> subunits, ATP6V0A2 and ATP6V0A4. J. Biol. Chem. 293, 2787\u20132800."},{"key":"48","doi-asserted-by":"publisher","unstructured":"48) Sun-Wada, G.H., Yoshimizu, T., Imai-Senga, Y., Wada, Y. and Futai, M. (2003) Diversity of mouse proton-translocating ATPase: Presence of multiple isoforms of the <i>C<\/i>, <i>d<\/i> and <i>G<\/i> subunits. Gene 302, 147\u2013153.","DOI":"10.1016\/S0378-1119(02)01099-5"},{"key":"49","unstructured":"49) Nishi, T., Kawasaki-Nishi, S. and Forgac, M. (2003) Expression and function of the mouse V-ATPase d subunit isoforms. J. Biol. Chem. 278, 46396\u201346402."},{"key":"50","unstructured":"50) Matsumoto, N., Daido, S., Sun-Wada, G.H., Wada, Y., Futai, M. and Nakanishi-Matsui, M. (2014) Diversity of proton pumps in osteoclasts: V-ATPase with <i>a<\/i>3 and <i>d<\/i>2 isoforms is a major form in osteoclasts. Biochim. Biophys. Acta 1837, 744\u2013749."},{"key":"51","unstructured":"51) Karet, F.E., Finberg, K.E., Nelson, R.D., Nayir, A., Mocan, H., Sanjad, S.A.  (1999) Mutations in the gene encoding B1 subunit of H<sup>+<\/sup>-ATPase cause renal tubular acidosis with sensorineural deafness. Nat. Genet. 21, 84\u201390."},{"key":"52","unstructured":"52) Sun-Wada, G.H., Murata, Y., Namba, M., Yamamoto, A., Wada, Y. and Futai, M. (2003) Mouse proton pump ATPase <i>C<\/i> subunit isoforms (<i>C<\/i>2-a and <i>C<\/i>2-b) specifically expressed in kidney and lung. J. Biol. Chem. 278, 44843\u201344851."},{"key":"53","unstructured":"53) Murata, Y., Sun-Wada, G.H., Yoshimizu, T., Yamamoto, A., Wada, Y. and Futai, M. (2002) Differential localization of the vacuolar H<sup>+<\/sup> pump with <i>G<\/i> subunit isoforms (<i>G<\/i>1 and <i>G<\/i>2) in mouse neurons. J. Biol. Chem. 277, 36296\u201336303."},{"key":"54","unstructured":"54) Kawamura, N., Sun-Wada, G.H. and Wada, Y. (2015) Loss of <i>G<\/i>2 subunit of vacuolar-type proton transporting ATPase leads to <i>G<\/i>1 subunit upregulation in the brain. Sci. Rep. 5, 14027."},{"key":"55","unstructured":"55) Wadsworth, S.J. and Chander, A. (2000) H<sup>+<\/sup>- and K<sup>+<\/sup>-dependence of Ca<sup>2+<\/sup> uptake in lung lamellar bodies. J. Membr. Biol. 174, 41\u201351."},{"key":"56","unstructured":"56) Sun-Wada, G.H., Imai-Senga, Y., Yamamoto, A., Murata, Y., Hirata, T., Wada, Y.  (2002) A proton pump ATPase with testis-specific <i>E<\/i>1-subunit isoform required for acrosome acidification. J. Biol. Chem. 277, 18098\u201318105."},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Imai-Senga, Y., Sun-Wada, G.H., Wada, Y. and Futai, M. (2002) A human gene, <i>ATP6E1<\/i>, encoding a testis-specific isoform of H<sup>+<\/sup>-ATPase subunit <i>E<\/i>. Gene 289, 7\u201312.","DOI":"10.1016\/S0378-1119(02)00542-5"},{"key":"58","unstructured":"58) Hayashi, K., Sun-Wada, G.H., Wada, Y., Nakanishi-Matsui, M. and Futai, M. (2008) Defective assembly of a hybrid vacuolar H<sup>+<\/sup>-ATPase containing the mouse testis-specific <i>E<\/i>1 isoform and yeast subunits. Biochim. Biophys. Acta 1777, 1370\u20131377."},{"key":"59","unstructured":"59) Okamoto-Terry, H., Umeki, K., Nakanishi-Matsui, M. and Futai, M. (2013) Glu-44 in the amino-terminal \u03b1-helix of yeast vacuolar ATPase E subunit (Vma4p) has a role for V<sub>o<\/sub>V<sub>1<\/sub> assembly. J. Biol. Chem. 288, 36236\u201336243."},{"key":"60","unstructured":"60) Kane, P.M. (2006) The where, when, and how of organelle acidification by the yeast vacuolar H<sup>+<\/sup>-ATPase. Microbiol. Mol. Biol. Rev. 70, 177\u2013191."},{"key":"61","unstructured":"61) Lu, M., Sautin, Y.Y., Holiday, S. and Gluck, S.L. (2004) The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H<sup>+<\/sup>-ATPase. J. Biol. Chem. 279, 8732\u20138739."},{"key":"62","unstructured":"62) Rahman, S., Yamato, I., Saijo, S., Mizutani, K., Takamuku, Y., Ishizuka-Katsura, Y.  (2016) Binding interactions of the peripheral stalk subunit isoforms form human V-ATPase. Biosci. Biotechnol. Biochem. 80, 878\u2013890."},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Rahman, S., Yamato, I., Saijo, S., Mizutani, K., Ishizuka-Katsura, Y., Ohsawa, N.  (2013) Biochemical and biophysical properties of interactions between subunits of the peripheral stalk region of human V-ATPase. PLoS One 8, e55704.","DOI":"10.1371\/journal.pone.0055704"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Sahara, Y., Horie, S., Fukami, H., Goto-Matsumoto, N. and Nakanishi-Matsui, M. (2015) Functional roles of V-ATPase in the salivary gland. J. Oral Biosci. 57, 102\u2013109.","DOI":"10.1016\/j.job.2014.11.002"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Pietrement, C., Sun-Wada, G.H., Da Silva, N., McKee, M., Marshansky, V., Brown, D.  (2006) Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis. Biol. Reprod. 74, 185\u2013194.","DOI":"10.1095\/biolreprod.105.043752"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66) Lehenkari, P., Hentunen, T.A., Laitala-Leinonen, T., Tuukkanen, J. and V\u00e4\u00e4n\u00e4nen, H.K. (1998) Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca<sup>2+<\/sup>. Exp. Cell Res. 242, 128\u2013137.","DOI":"10.1006\/excr.1998.4071"},{"key":"67","unstructured":"67) Kornak, U., Schulz, A., Friedrich, W., Uhlhaas, S., Kremens, B., Voit, T.  (2000) Mutations in the a3 subunit of the vacuolar H<sup>+<\/sup>-ATPase cause infantile malignant oeteopetrosis. Hum. Mol. Genet. 9, 2059\u20132063."},{"key":"68","unstructured":"68) Sobacchi, C., Franttini, A., Orhard, P., Porras, O. and Tezcan, I. (2001) The mutational spectrum of human malignant autosomal recessive osteopetrosis. Hum. Mol. Genet. 10, 1767\u20131773."},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) Kasper, D., Planells-Cases, R., Fuhrmann, J.C., Scheel, O., Zeitz, O., Ruether, K.  (2005) Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration. EMBO J. 24, 1079\u20131091.","DOI":"10.1038\/sj.emboj.7600576"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Nakanishi-Matsui, M., Yano, S. and Futai, M. (2013) Lipopolysaccharide-induced multinuclear cells: Increased internalization of polystyrene beads and possible signals for cell fusion. Biochem. Biophys. Res. Commun. 440, 611\u2013616.","DOI":"10.1016\/j.bbrc.2013.09.109"},{"key":"71","unstructured":"71) Matsumoto, N., Sekiya, M., Tohyama, K., Ishiyama-Matsuura, E., Sun-Wada, G.H., Wada, Y.  (2018) Essential role of the <i>a<\/i>3 isoform of V-ATPase in secretory lysosome trafficking via Rab7 recruitment. Sci. Rep. 8, 6701."},{"key":"72","unstructured":"72) Lee, S.H., Rho, J., Jeong, D., Sul, J.Y., Kim, T., Kim, N.  (2006) v-ATPase V<sub>o<\/sub> subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat. Med. 12, 1403\u20131409."},{"key":"73","unstructured":"73) Stenmark, H. (2009) Rab GTPases as coordinators of vesicle traffic. Nat. Rev. Mol. Cell Biol. 10, 513\u2013525."},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Bhuin, T. and Roy, J.K. (2014) Rab proteins: The key regulators of intracellular vesicle transport. Exp. Cell Res. 328, 1\u201319.","DOI":"10.1016\/j.yexcr.2014.07.027"},{"key":"75","unstructured":"75) Zhao, H., Laitala-Leinonen, T., Parikka, V. and V\u00e4\u00e4n\u00e4nen, H.K. (2001) Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. J. Biol. Chem. 276, 39295\u201339302."},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Haddad, E.K., Wu, X., Hammer, J.A. 3rd and Henkart, P.A. (2001) Defective granule exocytosis in Rab27a-deficient lymphocytes from <i>Ashen<\/i> mice. J. Cell Biol. 152, 835\u2013842.","DOI":"10.1083\/jcb.152.4.835"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Stinchcombe, J.C., Barral, D.C., Mules, E.H., Booth, S., Hume, A.N., Machesky, L.M.  (2001) Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J. Cell Biol. 152, 825\u2013834.","DOI":"10.1083\/jcb.152.4.825"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78) Sun-Wada, G.H., Toyomura, T., Murata, Y., Yamamoto, A., Futai, M. and Wada, Y. (2006) The <i>a<\/i>3 isoform of V-ATPase regulates insulin secretion from pancreatic \u03b2-cell. J. Cell Sci. 119, 4531\u20134540.","DOI":"10.1242\/jcs.03234"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Sun-Wada, G.H., Tabata, H., Kawamura, N., Futai, M. and Wada, Y. (2007) Differential expression of <i>a<\/i> subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues. Cell Tissue Res. 329, 239\u2013248.","DOI":"10.1007\/s00441-007-0421-7"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80) Morel, N., Dedieu, J.C. and Philippe, J.M. (2003) Specific sorting of the a1 isoform of the V-H<sup>+<\/sup>-ATPase a subunit to nerve terminals where it associated with both synaptic vesicles and the presynaptic plasma membrane. J. Cell Sci. 116, 4751\u20134762.","DOI":"10.1242\/jcs.00791"},{"key":"81","unstructured":"81) Umata, T., Moriyama, Y., Futai, M. and Mekada, E. (1990) The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin Al, a specific inhibitor of vacuolar-type H<sup>+<\/sup>-ATPase. J. Biol. Chem. 265, 21940\u201321945."},{"key":"82","unstructured":"82) Geyer, M., Yu, H., Mandic, R., Linnemann, T., Zheng, Y.H., Fackler, O.T.  (2002) Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. J. Biol. Chem. 277, 28521\u201328529."},{"key":"83","doi-asserted-by":"crossref","unstructured":"83) Pearse, B.M. and Robinson, M.S. (1990) Clathrin, adaptors, and sorting. Annu. Rev. Cell Biol. 6, 151\u2013171.","DOI":"10.1146\/annurev.cb.06.110190.001055"},{"key":"84","unstructured":"84) Ho, M.N., Hirata, R., Umemoto, N., Ohya, Y., Takatsuki, A., Stevens, T.H.  (1993) VMA13 encodes a 54-kDa vacuolar H<sup>+<\/sup>-ATPase subunit required for activity but not assembly of the enzyme complex in <i>Saccharomyces cerevisiae<\/i>. J. Biol. Chem. 268, 18286\u201318292."},{"key":"85","unstructured":"85) Maranda, B., Brown, D., Bourgoin, S., Casanova, J.E., Vinay, P., Ausiello, D.A.  (2001) Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes. J. Biol. Chem. 276, 18540\u201318550."},{"key":"86","unstructured":"86) Hurtado-Lorenzo, A., Skinner, M., El Annan, J., Futai, M., Sun-Wada, G.H., Bourgoin, S.  (2006) V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat. Cell Biol. 8, 124\u2013136."},{"key":"87","unstructured":"87) Futai, M. (2006) Our research on proton pumping ATPases over three decades: Their biochemistry, molecular biology and cell biology. Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 82, 416\u2013438."}],"container-title":["Proceedings of the Japan Academy, Series B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/pjab\/95\/6\/95_PJA9506B-04\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T03:31:25Z","timestamp":1560569485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/pjab\/95\/6\/95_PJA9506B-04\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":87,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.2183\/pjab.95.018","relation":{},"ISSN":["0386-2208","1349-2896"],"issn-type":[{"value":"0386-2208","type":"print"},{"value":"1349-2896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]}}}