{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:28:01Z","timestamp":1740144481562,"version":"3.37.3"},"reference-count":33,"publisher":"Japanese Association of Rural Medicine","issue":"3","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K21192"],"award-info":[{"award-number":["JP21K21192"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K16260"],"award-info":[{"award-number":["JP23K16260"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rural Med"],"published-print":{"date-parts":[[2024]]},"DOI":"10.2185\/jrm.2024-018","type":"journal-article","created":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T22:22:21Z","timestamp":1719786141000},"page":"186-191","source":"Crossref","is-referenced-by-count":0,"title":["Association between sTREM2, an immune biomarker of microglial activation, and          frontal lobe function in community-dwelling older adults: a cross-sectional          study"],"prefix":"10.2185","volume":"19","author":[{"given":"Ryuzo","family":"Orihashi","sequence":"first","affiliation":[{"name":"Institute of Nursing, Faculty of Medicine, Saga University,              Japan"},{"name":"Department of Psychiatry, Faculty of Medicine, Saga University,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiomi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Saga University,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Saga University,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"995","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Nabeta              H, Mizoguchi              Y, Matsushima              J, et al.            Association of salivary cortisol levels and later depressive state in            elderly people living in a rural community: a 3-year follow-up study.            J Affect Disord          2014; 158: 85\u201389.","DOI":"10.1016\/j.jad.2014.02.003"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Matsushima              J, Kawashima              T, Nabeta              H, et al.            Association of inflammatory biomarkers with depressive symptoms and            cognitive decline in a community-dwelling healthy older sample: a 3-year follow-up            study. J Affect Disord          2015; 173: 9\u201314.","DOI":"10.1016\/j.jad.2014.10.030"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Imamura              Y, Mizoguchi              Y, Nabeta              H, et al.            An association between belief in life after death and serum oxytocin in            older people in rural Japan. Int J Geriatr Psychiatry          2017; 32: 102\u2013109.","DOI":"10.1002\/gps.4453"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Orihashi              R, Mizoguchi              Y, Imamura              Y, et al.            Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year            follow-up study. Brain Commun          2020; 2: fcaa081.","DOI":"10.1093\/braincomms\/fcaa081"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Orihashi              R, Mizoguchi              Y, Imamura              Y, et al.            Association between sTREM2, an immune biomarker of microglial activation,            and aging-related brain volume changes in community-dwelling older adults: a 7-year            follow-up study. Front Aging Neurosci          2021; 13: 665612.","DOI":"10.3389\/fnagi.2021.665612"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Orihashi              R, Imamura              Y, Yamada              S, et al.            Association between cortisol and aging-related hippocampus volume changes            in community-dwelling older adults: a 7-year follow-up study.            BMC Geriatr          2022; 22: 765.","DOI":"10.1186\/s12877-022-03455-z"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kunitake              Y, Mizoguchi              Y, Imamura              Y, et al.            Serum oxytocin correlated with later logical memory in older Japanese            women: a 7-year follow-up study. Compr            Psychoneuroendocrinol          2022; 13: 100166.","DOI":"10.1016\/j.cpnec.2022.100166"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Ohishi-Fukuchi              J, Imamura              Y, Orihashi              R, et al.            Salivary 3-methoxy-4-hydroxyphenylglycol and MRI-based volume change of            the precuneus in community-dwelling elderly people.            Psychogeriatrics          2023; 23: 675\u2013681.","DOI":"10.1111\/psyg.12976"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ulrich              JD, Holtzman              DM. TREM2            function in Alzheimer\u2019s disease and neurodegeneration. ACS Chem            Neurosci          2016; 7: 420\u2013427.","DOI":"10.1021\/acschemneuro.5b00313"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ulrich              JD, Ulland              TK, Colonna              M, et al.            Elucidating the role of TREM2 in Alzheimer\u2019s disease.            Neuron          2017; 94: 237\u2013248.","DOI":"10.1016\/j.neuron.2017.02.042"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wunderlich              P, Glebov              K, Kemmerling              N, et al.            Sequential proteolytic processing of the triggering receptor expressed on            myeloid cells-2 (TREM2) protein by ectodomain shedding and \u03b3-secretase-dependent            intramembranous cleavage. J Biol Chem          2013; 288: 33027\u201333036.","DOI":"10.1074\/jbc.M113.517540"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kleinberger              G, Yamanishi              Y,                Su\u00e1rez-Calvet              M, et al.            TREM2 mutations implicated in neurodegeneration impair cell surface            transport and phagocytosis. Sci Transl Med          2014; 6: 243ra86.","DOI":"10.1126\/scitranslmed.3009093"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Zhong              L, Chen              XF, Wang              T, et al.            Soluble TREM2 induces inflammatory responses and enhances microglial            survival. J Exp Med          2017; 214: 597\u2013607.","DOI":"10.1084\/jem.20160844"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Zhong              L, Xu              Y, Zhuo              R, et al.            Soluble TREM2 ameliorates pathological phenotypes by modulating            microglial functions in an Alzheimer\u2019s disease model. Nat            Commun          2019; 10: 1365.","DOI":"10.1038\/s41467-019-09118-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hu              N, Tan              MS, Yu              JT, et al.            Increased expression of TREM2 in peripheral blood of Alzheimer\u2019s disease            patients. J Alzheimers Dis          2014; 38: 497\u2013501.","DOI":"10.3233\/JAD-130854"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Henjum              K, Almdahl              IS, \u00c5rskog              V, et al.            Cerebrospinal fluid soluble TREM2 in aging and Alzheimer\u2019s            disease. Alzheimers Res Ther          2016; 8: 17.","DOI":"10.1186\/s13195-016-0182-1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Heslegrave              A, Heywood              W, Paterson              R, et al.            Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer\u2019s            disease. Mol Neurodegener          2016; 11: 3.","DOI":"10.1186\/s13024-016-0071-x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Piccio              L, Deming              Y, Del-\u00c1guila              JL, et al.            Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and            associated with mutation status. Acta Neuropathol          2016; 131: 925\u2013933.","DOI":"10.1007\/s00401-016-1533-5"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Su\u00e1rez-Calvet              M,                Kleinberger              G, Araque                Caballero              M\u00c1, et al.            sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia            activity in early-stage Alzheimer\u2019s disease and associate with neuronal injury            markers. EMBO Mol Med          2016; 8: 466\u2013476.","DOI":"10.15252\/emmm.201506123"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Liu              D, Cao              B, Zhao              Y, et al.            Soluble TREM2 changes during the clinical course of Alzheimer\u2019s disease:            a meta-analysis. Neurosci Lett          2018; 686: 10\u201316.","DOI":"10.1016\/j.neulet.2018.08.038"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ohara              T, Hata              J, Tanaka              M, et al.            Serum soluble triggering receptor expressed on myeloid cells 2 as a            biomarker for incident dementia: the Hisayama study. Ann            Neurol          2019; 85: 47\u201358.","DOI":"10.1002\/ana.25385"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Folstein              MF, Folstein              SE, McHugh              PR.            \u201cMini-mental state\u201d. A practical method for grading the cognitive state            of patients for the clinician. J Psychiatr Res          1975; 12: 189\u2013198.","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Hughes              CP, Berg              L, Danziger              WL, et al.            A new clinical scale for the staging of dementia.            Br J Psychiatry          1982; 140: 566\u2013572.","DOI":"10.1192\/bjp.140.6.566"},{"key":"24","first-page":"2412","volume":"43","year":"1993","unstructured":"24. Morris              JC. The            Clinical Dementia Rating (CDR): current version and scoring rules.            Neurology          1993; 43: 2412\u20132414.","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Dubois              B, Slachevsky              A, Litvan              I, et al.            The FAB: a frontal assessment battery at bedside.            Neurology          2000; 55: 1621\u20131626.","DOI":"10.1212\/WNL.55.11.1621"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Tanaka              M, Honda              T, Yamakage              H, et al.            A potential novel pathological implication of serum soluble triggering            receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese            population: the Hisayama study. Diabetes Res Clin Pract          2018; 146: 225\u2013232.","DOI":"10.1016\/j.diabres.2018.10.007"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Tanaka              M, Yamakage              H, Masuda              S, et al.            Serum soluble TREM2 is a potential novel biomarker of cognitive            impairment in Japanese non-obese patients with diabetes.            Diabetes Metab          2019; 45: 86\u201389.","DOI":"10.1016\/j.diabet.2017.06.006"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Malpetti              M, Cope              TE, Street              D, et al.            Microglial activation in the frontal cortex predicts cognitive decline in            frontotemporal dementia. Brain          2023; 146: 3221\u20133231.","DOI":"10.1093\/brain\/awad078"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Satoh-Asahara              N, Yamakage              H, Tanaka              M, et al.            Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood            of patients with diabetes based on their cognitive status.            Diabetes Res Clin Pract          2022; 193: 110121.","DOI":"10.1016\/j.diabres.2022.110121"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Ewers              M, Franzmeier              N,                Su\u00e1rez-Calvet              M, et al.            Alzheimer\u2019s Disease Neuroimaging            Initiative.Increased soluble TREM2 in cerebrospinal fluid            is associated with reduced cognitive and clinical decline in Alzheimer\u2019s            disease. Sci Transl Med          2019; 11: eaav6221.","DOI":"10.1126\/scitranslmed.aav6221"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Jay              TR, von                Saucken              VE, Landreth              GE. TREM2 in            neurodegenerative diseases. Mol Neurodegener          2017; 12: 56.","DOI":"10.1186\/s13024-017-0197-5"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Kim              SM, Mun              BR, Lee              SJ, et al.            TREM2 promotes A\u03b2 phagocytosis by upregulating C\/EBP\u03b1-dependent CD36            expression in microglia. Sci Rep          2017; 7: 11118.","DOI":"10.1038\/s41598-017-11634-x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Zheng              H, Liu              CC, Atagi              Y, et al.            Opposing roles of the triggering receptor expressed on myeloid cells 2            and triggering receptor expressed on myeloid cells-like transcript 2 in microglia            activation. Neurobiol Aging          2016; 42: 132\u2013141.","DOI":"10.1016\/j.neurobiolaging.2016.03.004"}],"container-title":["Journal of Rural Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrm\/19\/3\/19_2024-018\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T04:22:06Z","timestamp":1720239726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrm\/19\/3\/19_2024-018\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2185\/jrm.2024-018","relation":{},"ISSN":["1880-487X","1880-4888"],"issn-type":[{"type":"print","value":"1880-487X"},{"type":"electronic","value":"1880-4888"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"2024-018"}}