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Burden \nof high fracture probability worldwide: secular increases 2010\u20132040. \nOsteoporos Int 2015; 26: 2243-8. https:\/\/doi.org\/10.1007\/s00198-015-3154-6","DOI":"10.1007\/s00198-015-3154-6"},{"key":"2","doi-asserted-by":"crossref","unstructured":"[2]   Russell RG. Bisphosphonates: from bench to bedside. Ann N Y Acad Sci \n2006; 1068: 367-401. https:\/\/doi.org\/10.1196\/annals.1346.041","DOI":"10.1196\/annals.1346.041"},{"key":"3","doi-asserted-by":"crossref","unstructured":"[3]   Rennert G, Pinchev M, Gronich N, Saliba W, Flugelman A, Lavi I, et \nal. Oral Bisphosphonates and Improved Survival of Breast Cancer. Clin \nCancer Res 2017; 23: 1684-9. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-0547","DOI":"10.1158\/1078-0432.CCR-16-0547"},{"key":"4","doi-asserted-by":"crossref","unstructured":"[4]   Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced \navascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg \n2003; 61: 1115-7. https:\/\/doi.org\/10.1016\/s0278-2391(03)00720-1","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"5","doi-asserted-by":"crossref","unstructured":"[5]   Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra \nB, et al. American Association of Oral and Maxillofacial Surgeons \nposition paper on medication-related osteonecrosis of the jaw--2014 \nupdate. J Oral Maxillofac Surg 2014; 72: 1938-56. https:\/\/doi.org\/10.1016\/j.joms.2014.04.031","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"6","doi-asserted-by":"crossref","unstructured":"[6]   Holzinger D, Seemann R, Matoni N, Ewers R, Millesi W, Wutzl A. \nEffect of dental implants on bisphosphonate-related osteonecrosis of the \njaws. 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PLoS One \n2015; 10: e0144355. https:\/\/doi.org\/10.1371\/journal.pone.0144355","DOI":"10.1371\/journal.pone.0144355"},{"key":"45","doi-asserted-by":"crossref","unstructured":"[45]   Song M, Alshaikh A, Kim T, Kim S, Dang M, Mehrazarin S, et al. \nPreexisting Periapical Inflammatory Condition Exacerbates Tooth \nExtraction-induced Bisphosphonate-related Osteonecrosis of the Jaw \nLesions in Mice. J Endod 2016; 42: 1641-6. https:\/\/doi.org\/10.1016\/j.joen.2016.07.020","DOI":"10.1016\/j.joen.2016.07.020"},{"key":"46","doi-asserted-by":"crossref","unstructured":"[46]   Otto S, Tr\u00f6ltzsch M, Jambrovic V, Panya S, Probst F, Ristow O, et al. \nTooth extraction in patients receiving oral or intravenous bisphosphonate \nadministration: A trigger for BRONJ development? 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Metformin \nenhances the differentiation and mineralization of osteoblastic MC3T3-E1 \ncells via AMP kinase activation as well as eNOS and BMP-2 expression. \nBiochem Biophys Res Commun 2008; 375: 414-9. https:\/\/doi.org\/10.1016\/j.bbrc.2008.08.034","DOI":"10.1016\/j.bbrc.2008.08.034"},{"key":"49","doi-asserted-by":"crossref","unstructured":"[49]   Cortizo AM, Sedlinsky C, McCarthy AD, Blanco A, Schurman L. \nOsteogenic actions of the anti-diabetic drug metformin on osteoblasts \nin culture. Eur J Pharmacol 2006; 536: 38-46. https:\/\/doi.org\/10.1016\/j.ejphar.2006.02.030","DOI":"10.1016\/j.ejphar.2006.02.030"},{"key":"50","doi-asserted-by":"crossref","unstructured":"[50]   Kuroshima S, Nakajima K, Sasaki M, I T, Sumita Y, Asahara T, Asahina \nI, Sawase T. Systemic administration of quality- and quantity-controlled \nPBMNCs reduces bisphosphonate-related osteonecrosis of jaw-like lesions \nin mice. Stem Cell Res Ther 2019; 10: 209. https:\/\/doi.org\/10.1186\/s13287-019-1308-8","DOI":"10.1186\/s13287-019-1308-8"},{"key":"51","doi-asserted-by":"crossref","unstructured":"[51]   Ara\u00fajo AA, Pereira ASBF, Medeiros CACX, Brito GAC, Leit\u00e3o RFC, \nAra\u00fajo LS, Guedes PMM, Hiyari S, Pirih FQ, Ara\u00fajo J\u00fanior RF. Effects of \nmetformin on inflammation, oxidative stress, and bone loss in a rat model \nof periodontitis. 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