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Clinical and histological findings of denture stomatitis as related to intraoral colonization patterns of Candidaalbicans, salivary flow, and dry mouth. J Prosthodont. 2013;22:13\u201322. PMID:23107189, https:\/\/doi.org\/10.1111\/j.1532-849X.2012.00906.x","DOI":"10.1111\/j.1532-849X.2012.00906.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"[31] Walker DM. Oral mucosal immunology: an overview. Ann Acad Med Singap. 2004;33(suppl):27\u201330. PMID:15389303","DOI":"10.47102\/annals-acadmedsg.V33N4p27S"},{"key":"32","doi-asserted-by":"crossref","unstructured":"[32] Mese H, Matsuo R. Salivary secretion, taste and hyposalivation. J Oral Rehabil. 2007;34:711\u201323. PMID:17824883, https:\/\/doi.org\/10.1111\/j.1365-2842.2007.01794.x","DOI":"10.1111\/j.1365-2842.2007.01794.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"[33] Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. J Oral Microbiol. 2011;3:5771. 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