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Race to invade: understanding soft tissue integration at the transmucosal          region of titanium dental implants. Dent Mater. 2021;37:816\u201331.          https:\/\/doi.org\/10.1016\/j.dental.2021.02.005 PMID:33676764","DOI":"10.1016\/j.dental.2021.02.005"},{"key":"2","doi-asserted-by":"publisher","unstructured":"[2]  Chai WL,Moharamzadeh K,Brook IM,Van Noort R. A          review of histomorphometric analysis techniques for assessing implant-soft tissue          interface. Biotech Histochem. 2011;86:242\u201354. https:\/\/doi.org\/10.3109\/10520291003707916          PMID:20392135","DOI":"10.3109\/10520291003707916"},{"key":"3","doi-asserted-by":"publisher","unstructured":"[3]  Saini M,Singh Y,Arora P,Arora V,Jain K. Implant          biomaterials: A comprehensive review. World J Clin Cases. 2015;3:52\u20137.          https:\/\/doi.org\/10.12998\/wjcc.v3.i1.52 PMID:25610850","DOI":"10.12998\/wjcc.v3.i1.52"},{"key":"4","doi-asserted-by":"publisher","unstructured":"[4]  Manicone PF,Iommetti PR,Raffaelli L,Paolantonio          M,Rossi G,Berardi D,<i>et al.<\/i> Biological considerations on the use of          zirconia for dental devices. Int J Immunopathol Pharmacol. 2007;20(suppl 1):9\u201312.          https:\/\/doi.org\/10.1177\/039463200702001s03 PMID:17897494","DOI":"10.1177\/039463200702001s03"},{"key":"5","doi-asserted-by":"publisher","unstructured":"[5]  Hossain N,Mobarak MH,Islam MA,Hossain A,Al          Mahmud MZ,Rayhan MT,<i>et al.<\/i> Recent development of dental implant          materials, synthesis process, and failure \u2013 A review. Results Chem. 2023;6:101136.          https:\/\/doi.org\/10.1016\/j.rechem.2023.101136","DOI":"10.1016\/j.rechem.2023.101136"},{"key":"6","doi-asserted-by":"publisher","unstructured":"[6]  Zhang Y,Zhang W,Yang M,Li M,Zhou L,Liu            Y,<i>et al.<\/i> Comprehensive review of polyetheretherketone use in dentistry.          J Prosthodont Res. 2025;69:215\u201332. https:\/\/doi.org\/10.2186\/jpr.JPR_D_24_00142          PMID:39756889","DOI":"10.2186\/jpr.JPR_D_24_00142"},{"key":"7","doi-asserted-by":"publisher","unstructured":"[7]  Ghazal-Maghras R,Vilaplana-Vivo J,Camacho-Alonso          F,Mart\u00ednez-Beneyto Y. Properties of polyetheretheretherketone (PEEK) implant abutments: A          systematic review. J Clin Exp Dent. 2022;14:e349\u201358. https:\/\/doi.org\/10.4317\/jced.59466          PMID:35419181","DOI":"10.4317\/jced.59466"},{"key":"8","doi-asserted-by":"publisher","unstructured":"[8]  Morita D,Matsuzaki T,Sakai N,Ogino Y,Atsuta          I,Ayukawa Y. Influence of material and tightening torque on the subsidence of implant scan          bodies. J Prosthodont Res. 2025;JPR_D_24_00224; Online ahead of print.          https:\/\/doi.org\/10.2186\/jpr.JPR_D_24_00224 PMID:40175100","DOI":"10.2186\/jpr.JPR_D_24_00224"},{"key":"9","doi-asserted-by":"crossref","unstructured":"[9]  Page MJ,McKenzie JE,Bossuyt PM,Boutron          I,Hoffmann TC,Mulrow CD,<i>et al.<\/i> The PRISMA 2020 statement: an updated          guideline for reporting systematic reviews. BMJ. 2021;372:n71.          https:\/\/doi.org\/10.1136\/bmj.n71 PMID:33782057","DOI":"10.1136\/bmj.n71"},{"key":"10","doi-asserted-by":"publisher","unstructured":"[10]  Wang T,Matinlinna JP,Burrow MF,Ahmed KE. The          biocompatibility of glass-fibre reinforced composites (GFRCs) \u2013 a systematic review. J          Prosthodont Res. 2021;65:273\u201383. https:\/\/doi.org\/10.2186\/jpr.JPR_D20_00031          PMID:34421062","DOI":"10.2186\/jpr.JPR_D20_00031"},{"key":"11","doi-asserted-by":"publisher","unstructured":"[11]  Sarkis-Onofre R,Skupien JA,Cenci MS,Moraes          RR,Pereira-Cenci T. The role of resin cement on bond strength of glass-fiber posts luted          into root canals: a systematic review and meta-analysis of in vitro studies. Oper Dent.          2014;39:E31\u201344. https:\/\/doi.org\/10.2341\/13-070-LIT PMID:23937401","DOI":"10.2341\/13-070-LIT"},{"key":"12","doi-asserted-by":"publisher","unstructured":"[12]  Hu J,Atsuta I,Luo Y,Wang X,Jiang Q. Promotional          effect and molecular mechanism of synthesized zinc oxide nanocrystal on zirconia abutment          surface for soft tissue sealing. J Dent Res. 2023;102:505\u201313.          https:\/\/doi.org\/10.1177\/00220345221150161 PMID:36883651","DOI":"10.1177\/00220345221150161"},{"key":"13","doi-asserted-by":"publisher","unstructured":"[13]  Mem\u00e8 L,Sartini D,Pozzi V,Emanuelli M,Strappa          EM,Bittarello P,<i>et al.<\/i> Epithelial biological response to machined          titanium vs. PVD zirconium-coated titanium: An in vitro study. Materials (Basel).          2022;15:7250. https:\/\/doi.org\/10.3390\/ma15207250 PMID:36295315","DOI":"10.3390\/ma15207250"},{"key":"14","doi-asserted-by":"publisher","unstructured":"[14]  Lee DJ,Ryu JS,Shimono M,Lee KW,Lee JM,Jung HS.          Differential healing patterns of mucosal seal on zirconia and titanium implant. Front          Physiol. 2019;10:796. https:\/\/doi.org\/10.3389\/fphys.2019.00796          PMID:31333481","DOI":"10.3389\/fphys.2019.00796"},{"key":"15","doi-asserted-by":"publisher","unstructured":"[15]  Deng Z,Liang J,Fang N,Li X. Integration of          collagen fibers in connective tissue with dental implant in the transmucosal region. Int J          Biol Macromol. 2022;208:833\u201343. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.03.195          PMID:35367473","DOI":"10.1016\/j.ijbiomac.2022.03.195"},{"key":"16","doi-asserted-by":"publisher","unstructured":"[16]  Zeller B,St\u00f6ckli S,Zaugg LK,Astasov-Frauenhoffer          M,Hauser-Gerspach I,Waltimo T,<i>et al.<\/i> Biofilm formation on metal alloys,          zirconia and polyetherketoneketone as implant materials in vivo. Clin Oral Implants Res.          2020;31:1078\u201386. https:\/\/doi.org\/10.1111\/clr.13654 PMID:32871619","DOI":"10.1111\/clr.13654"},{"key":"17","doi-asserted-by":"publisher","unstructured":"[17]  Nothdurft FP,Fontana D,Ruppenthal S,May A,Aktas          C,Mehraein Y,<i>et al.<\/i> Differential behavior of fibroblasts and epithelial          cells on structured implant abutment materials: A comparison of materials and surface          topographies. Clin Implant Dent Relat Res. 2015;17:1237\u201349.          https:\/\/doi.org\/10.1111\/cid.12253 PMID:25066589","DOI":"10.1111\/cid.12253"},{"key":"18","doi-asserted-by":"publisher","unstructured":"[18]  Roy M,Corti A,Daniele S,Martini C,Cavallini          C,Piosik A,<i>et al.<\/i> Early changes of ECM-related gene expression in          fibroblasts cultured on TiO2, ZrO2 and PEEK: The beneficial effects of UVC          photofunctionalization. J Photochem Photobiol. 2021;6:100023.          https:\/\/doi.org\/10.1016\/j.jpap.2021.100023","DOI":"10.1016\/j.jpap.2021.100023"},{"key":"19","doi-asserted-by":"publisher","unstructured":"[19]  Huang C,Miao X,Li J,Liang J,Xu J,Wu Z. Promoted          abutment-soft tissue integration around self-glazed zirconia surfaces with nanotopography          fabricated by additive 3D gel deposition. Int J Nanomedicine. 2023;18:3141\u201355.          https:\/\/doi.org\/10.2147\/IJN.S404047 PMID:37333732","DOI":"10.2147\/IJN.S404047"},{"key":"20","doi-asserted-by":"crossref","unstructured":"[20]  Guo L,Smeets R,Kluwe L,Hartjen P,Barbeck          M,Cacaci C,<i>et al.<\/i> Cytocompatibility of titanium, zirconia and modified          PEEK after surface treatment using UV light or non-thermal plasma. Int J Mol Sci.          2019;20:5596. https:\/\/doi.org\/10.3390\/ijms20225596 PMID:31717459","DOI":"10.3390\/ijms20225596"},{"key":"21","doi-asserted-by":"publisher","unstructured":"[21]  Ramenzoni LL,Attin T,Schmidlin PR. In vitro          effect of modified polyetheretherketone (PEEK) implant abutments on human gingival          epithelial keratinocytes migration and proliferation. Materials (Basel). 2019;12:1401.          https:\/\/doi.org\/10.3390\/ma12091401 PMID:31036797","DOI":"10.3390\/ma12091401"},{"key":"22","doi-asserted-by":"publisher","unstructured":"[22]  Chokaree P,Poovarodom P,Chaijareenont P,Yavirach          A,Rungsiyakull P. Biomaterials and clinical applications of customized healing abutment-a          narrative review. J Funct Biomater. 2022;13:291. https:\/\/doi.org\/10.3390\/jfb13040291          PMID:36547551","DOI":"10.3390\/jfb13040291"},{"key":"23","doi-asserted-by":"publisher","unstructured":"[23]  Wang X,Ma N,Feng L,Shen M,Zhou Y,Zhang            X,<i>et al.<\/i> Fabrication of bFGF\/polydopamine-loaded PEEK implants for          improving soft tissue integration by upregulating Wnt\/\u03b2-catenin signaling. Heliyon.          2023;9:e14800. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e14800          PMID:37012909","DOI":"10.1016\/j.heliyon.2023.e14800"},{"key":"24","doi-asserted-by":"publisher","unstructured":"[24]  Guo C,Lu R,Wang X,Chen S. Graphene          oxide-modified polyetheretherketone with excellent antibacterial properties and          biocompatibility for implant abutment. Macromol Res. 2021;29:351\u20139.          https:\/\/doi.org\/10.1007\/s13233-021-9042-3","DOI":"10.1007\/s13233-021-9042-3"},{"key":"25","doi-asserted-by":"publisher","unstructured":"[25]  Grenade C,De Pauw-Gillet MC,Gailly P,Vanheusden          A,Mainjot A. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with          human gingival fibroblasts (HGFs). Dent Mater. 2016;32:1152\u201364.          https:\/\/doi.org\/10.1016\/j.dental.2016.06.020 PMID:27402299","DOI":"10.1016\/j.dental.2016.06.020"},{"key":"26","doi-asserted-by":"publisher","unstructured":"[26]  Cho YD,Shin JC,Yoon HI,Ku Y,Ryoo HM,Kim            DJ,<i>et al.<\/i> Characterization of human gingival fibroblasts on zirconia          surfaces containing niobium oxide. Materials (Basel). 2015;8:6018\u201328.          https:\/\/doi.org\/10.3390\/ma8095288 PMID:28793548","DOI":"10.3390\/ma8095288"},{"key":"27","doi-asserted-by":"publisher","unstructured":"[27]  Suzumura T,Matsuura T,Komatsu K,Sugita Y,Maeda          H,Ogawa T. Vacuum ultraviolet (VUV) light photofunctionalization to induce human oral          fibroblast transmigration on zirconia. Cells. 2023;12:2542.          https:\/\/doi.org\/10.3390\/cells12212542 PMID:37947620","DOI":"10.3390\/cells12212542"},{"key":"28","doi-asserted-by":"publisher","unstructured":"[28]  Yang Y,Zhou J,Liu X,Zheng M,Yang J,Tan J.          Ultraviolet light-treated zirconia with different roughness affects function of human          gingival fibroblasts in vitro : the potential surface modification developed from implant          to abutment. J Biomed Mater Res B Appl Biomater. 2015;103:116\u201324.          https:\/\/doi.org\/10.1002\/jbm.b.33183 PMID:24771524","DOI":"10.1002\/jbm.b.33183"},{"key":"29","doi-asserted-by":"publisher","unstructured":"[29]  Iinuma Y,Hirota M,Hayakawa T,Ohkubo C.          Surrounding tissue response to surface-treated zirconia implants. Materials (Basel).          2019;13:30. https:\/\/doi.org\/10.3390\/ma13010030 PMID:31861679","DOI":"10.3390\/ma13010030"},{"key":"30","doi-asserted-by":"publisher","unstructured":"[30]  Enkling N,Marder M,Bayer S,G\u00f6tz W,Stoilov          M,Kraus D. Soft tissue response to different abutment materials: A controlled and          randomized human study using an experimental model. Clin Oral Implants Res.          2022;33:667\u201379. https:\/\/doi.org\/10.1111\/clr.13932 PMID:35467040","DOI":"10.1111\/clr.13932"},{"key":"31","doi-asserted-by":"publisher","unstructured":"[31]  Cionca N,Hashim D,Cancela J,Giannopoulou          C,Mombelli A. Pro-inflammatory cytokines at zirconia implants and teeth. A cross-sectional          assessment. Clin Oral Investig. 2016;20:2285\u201391. https:\/\/doi.org\/10.1007\/s00784-016-1729-z          PMID:26832782","DOI":"10.1007\/s00784-016-1729-z"},{"key":"32","doi-asserted-by":"publisher","unstructured":"[32]  Kumar Y,Jain V,Chauhan SS,Bharate V,Koli D,Kumar          M. Influence of different forms and materials (zirconia or titanium) of abutments in          peri-implant soft-tissue healing using matrix metalloproteinase-8: A randomized pilot          study. J Prosthet Dent. 2017;118:475\u201380. https:\/\/doi.org\/10.1016\/j.prosdent.2016.11.017          PMID:28343676","DOI":"10.1016\/j.prosdent.2016.11.017"},{"key":"33","doi-asserted-by":"publisher","unstructured":"[33]  Milinkovic I,Krasavcevic AD,Jankovic S,Sopta          J,Aleksic Z. Immunohistochemical analysis of soft tissue response to polyetheretherketone          (PEEK) and titanium healing abutments on dental implants: A randomized pilot clinical          study. BMC Oral Health. 2022;22:484. https:\/\/doi.org\/10.1186\/s12903-022-02536-0          PMID:36368972","DOI":"10.1186\/s12903-022-02536-0"},{"key":"34","doi-asserted-by":"publisher","unstructured":"[34]  Yang Y,Zhang H,Komasa S,Kusumoto T,Kuwamoto          S,Okunishi T,<i>et al.<\/i> Immunomodulatory properties and osteogenic activity          of polyetheretherketone coated with titanate nanonetwork structures. Int J Mol Sci.          2022;23:612. https:\/\/doi.org\/10.3390\/ijms23020612 PMID:35054795","DOI":"10.3390\/ijms23020612"},{"key":"35","doi-asserted-by":"publisher","unstructured":"[35]  Benz K,Sch\u00f6bel A,Dietz M,Maurer P,Jackowski J.          Adhesion behaviour of primary human osteoblasts and fibroblasts on polyether ether ketone          compared with titanium under in vitro lipopolysaccharide incubation. Materials (Basel).          2019;12:2739. https:\/\/doi.org\/10.3390\/ma12172739 PMID:31461861","DOI":"10.3390\/ma12172739"},{"key":"36","doi-asserted-by":"publisher","unstructured":"[36]  Rathe F,Junker R,Gr\u00f6ger S,Meyle J,Schlee M.          Inflammatory effects of individualized abutments bonded onto t ITANIUM BASE on          peri\u2010implant tissue health: A randomized controlled clinical trial. Clin Implant Dent          Relat Res. 2021;23:874\u201382. https:\/\/doi.org\/10.1111\/cid.13050          PMID:34668304","DOI":"10.1111\/cid.13050"},{"key":"37","doi-asserted-by":"publisher","unstructured":"[37]  de Avila ED,Avila-Campos MJ,Vergani          CE,Spolid\u00f3rio DMP,Mollo FA Jr. Structural and quantitative analysis of a mature anaerobic          biofilm on different implant abutment surfaces. J Prosthet Dent. 2016;115:428\u201336.          https:\/\/doi.org\/10.1016\/j.prosdent.2015.09.016 PMID:26597465","DOI":"10.1016\/j.prosdent.2015.09.016"},{"key":"38","doi-asserted-by":"publisher","unstructured":"[38]  Wiessner A,Wassmann T,Wiessner JM,Schubert          A,Wiechens B,Hampe T,<i>et al.<\/i> In vivo biofilm formation on novel PEEK,          titanium, and zirconia implant abutment materials. Int J Mol Sci. 2023;24:1779.          https:\/\/doi.org\/10.3390\/ijms24021779 PMID:36675292","DOI":"10.3390\/ijms24021779"},{"key":"39","doi-asserted-by":"publisher","unstructured":"[39]  Nascimento C,Pita MS,Fernandes FHNC,Pedrazzi          V,de Albuquerque Junior RF,Ribeiro RF. Bacterial adhesion on the titanium and zirconia          abutment surfaces. Clin Oral Implants Res. 2014;25:337\u201343.          https:\/\/doi.org\/10.1111\/clr.12093 PMID:23316996","DOI":"10.1111\/clr.12093"},{"key":"40","doi-asserted-by":"publisher","unstructured":"[40]  Tan X,Wang Z,Yang X,Yu P,Sun M,Zhao Y,<i>et            al.<\/i> Enhancing cell adhesive and antibacterial activities of          glass-fibre-reinforced polyetherketoneketone through Mg and Ag PIII. Regen Biomater.          2023;10:rbad066. https:\/\/doi.org\/10.1093\/rb\/rbad066 PMID:37489146","DOI":"10.1093\/rb\/rbad066"},{"key":"41","doi-asserted-by":"publisher","unstructured":"[41]  Montero JFD,Tajiri HA,Barra GMO,Fredel          MC,Benfatti CAM,Magini RS,<i>et al.<\/i> Biofilm behavior on sulfonated          poly(ether-ether-ketone) (sPEEK). Mater Sci Eng C. 2017;70:456\u201360.          https:\/\/doi.org\/10.1016\/j.msec.2016.09.017 PMID:27770916","DOI":"10.1016\/j.msec.2016.09.017"},{"key":"42","doi-asserted-by":"publisher","unstructured":"[42]  Barkarmo S,Longhorn D,Leer K,Johansson          CB,Stenport V,Franco-Tabares S,<i>et al.<\/i> Biofilm formation on          polyetheretherketone and titanium surfaces. Clin Exp Dent Res. 2019;5:427\u201337.          https:\/\/doi.org\/10.1002\/cre2.205 PMID:31452954","DOI":"10.1002\/cre2.205"},{"key":"43","doi-asserted-by":"publisher","unstructured":"[43]  D\u2019Ercole S,Cellini L,Pilato S,Di Lodovico          S,Iezzi G,Piattelli A,<i>et al.<\/i> Material characterization and Streptococcus          oralis adhesion on Polyetheretherketone (PEEK) and titanium surfaces used in implantology.          J Mater Sci Mater Med. 2020;31:84. https:\/\/doi.org\/10.1007\/s10856-020-06408-3          PMID:32989624","DOI":"10.1007\/s10856-020-06408-3"},{"key":"44","doi-asserted-by":"publisher","unstructured":"[44]  Peng TY,Lin DJ,Mine Y,Tasi CY,Li PJ,Shih            YH,<i>et al.<\/i> Biofilm formation on the surface of (poly)ether-ether-ketone          and in vitro antimicrobial efficacy of photodynamic therapy on peri-implant mucositis.          Polymers (Basel). 2021;13:940. https:\/\/doi.org\/10.3390\/polym13060940          PMID:33803736","DOI":"10.3390\/polym13060940"},{"key":"45","doi-asserted-by":"publisher","unstructured":"[45]  Sarfraz S,M\u00e4ntynen PH,Laurila M,Rossi S,Leikola          J,Kaakinen M,<i>et al.<\/i> Comparison of titanium and peek medical plastic          implant materials for their bacterial biofilm formation properties. Polymers (Basel).          2022;14:3862. https:\/\/doi.org\/10.3390\/polym14183862 PMID:36146003","DOI":"10.3390\/polym14183862"},{"key":"46","doi-asserted-by":"publisher","unstructured":"[46]  Desch A,Freifrau von Maltzahn N,Stumpp N,Dalton          M,Yang I,Stiesch M. Biofilm formation on zirconia and titanium over time\u2014an in vivo model          study. Clin Oral Implants Res. 2020;31:865\u201380. https:\/\/doi.org\/10.1111\/clr.13632          PMID:32583509","DOI":"10.1111\/clr.13632"},{"key":"47","doi-asserted-by":"publisher","unstructured":"[47]  Uhlmann E,Schweitzer L,Kieburg H,Spielvogel          A,Huth-Herms K. The effects of laser microtexturing of biomedical grade 5 Ti-6Al-4V dental          implants (abutment) on biofilm formation. Procedia CIRP. 2018;68:184\u20139.          https:\/\/doi.org\/10.1016\/j.procir.2017.12.044","DOI":"10.1016\/j.procir.2017.12.044"},{"key":"48","doi-asserted-by":"publisher","unstructured":"[48]  Y\u00fcce E,Sharifikolouei E,Micusik M,Ferraris          S,Rashidi R,Najmi Z,<i>et al.<\/i> Anticorrosion and antimicrobial tannic          acid-functionalized Ti-metallic glass ribbons for dental abutment. ACS Appl Bio Mater.          2024;7:936\u201349. https:\/\/doi.org\/10.1021\/acsabm.3c00948 PMID:38299869","DOI":"10.1021\/acsabm.3c00948"},{"key":"49","doi-asserted-by":"publisher","unstructured":"[49]  Wang X,Lu T,Wen J,Xu L,Zeng D,Wu Q,<i>et            al.<\/i> Selective responses of human gingival fibroblasts and bacteria on carbon          fiber reinforced polyetheretherketone with multilevel nanostructured TiO2. Biomaterials.          2016;83:207\u201318. https:\/\/doi.org\/10.1016\/j.biomaterials.2016.01.001          PMID:26774566","DOI":"10.1016\/j.biomaterials.2016.01.001"},{"key":"50","unstructured":"[50]Hung CCU,Costa RC,Pereira G,Abdo VL,Noronha          MDS,Retamal-Valdes B,<i>et al.<\/i> Oral microbial colonization on titanium and          polyetheretherketone dental implant healing abutments: An in vitro and in vivo study. J          Prosthet Dent 2023;S0022-3913:00538-3."},{"key":"51","doi-asserted-by":"publisher","unstructured":"[51]  Huang B,Liu C,Yang J,Xiang E,Ivanovski S,Han P.          Saliva biofilm-derived outer membrane vesicles regulate biofilm formation and immune          response of oral epithelial cells on titanium surfaces. Clin Oral Investig. 2024;28:75.          https:\/\/doi.org\/10.1007\/s00784-023-05454-9 PMID:38175302","DOI":"10.1007\/s00784-023-05454-9"},{"key":"52","doi-asserted-by":"publisher","unstructured":"[52]  Fr\u00f6jd V,Linderb\u00e4ck P,Wennerberg A,Ch\u00e1vez de Paz          L,Svens\u00e4ter G,Davies JR. Effect of nanoporous TiO2 coating and anodized Ca2+ modification          of titanium surfaces on early microbial biofilm formation. BMC Oral Health. 2011;11:8.          https:\/\/doi.org\/10.1186\/1472-6831-11-8 PMID:21385428","DOI":"10.1186\/1472-6831-11-8"},{"key":"53","doi-asserted-by":"publisher","unstructured":"[53]  Misch CE,Suzuki JB,Misch-Dietsh FM,Bidez MW. A          positive correlation between occlusal trauma and peri-implant bone loss: literature          support. Implant Dent. 2005;14:108\u201316. https:\/\/doi.org\/10.1097\/01.id.0000165033.34294.db          PMID:15968181","DOI":"10.1097\/01.id.0000165033.34294.db"},{"key":"54","doi-asserted-by":"publisher","unstructured":"[54]  Papaspyridakos P,Chen CJ,Singh M,Weber          HP,Gallucci GO. Success criteria in implant dentistry: A systematic review. J Dent Res.          2012;91:242\u20138. https:\/\/doi.org\/10.1177\/0022034511431252 PMID:22157097","DOI":"10.1177\/0022034511431252"},{"key":"55","doi-asserted-by":"publisher","unstructured":"[55]  Albrektsson T,Wennerberg A. On osseointegration          in relation to implant surfaces. Clin Implant Dent Relat Res. 2019;21(suppl 1):4\u20137.          https:\/\/doi.org\/10.1111\/cid.12742 PMID:30816639","DOI":"10.1111\/cid.12742"},{"key":"56","doi-asserted-by":"publisher","unstructured":"[56]  Berglundh T,Abrahamsson I,Welander M,Lang          NP,Lindhe J. Morphogenesis of the peri\u2010implant mucosa: an experimental study in dogs. Clin          Oral Implants Res. 2007;18:1\u20138. https:\/\/doi.org\/10.1111\/j.1600-0501.2006.01380.x          PMID:17224016","DOI":"10.1111\/j.1600-0501.2006.01380.x"},{"key":"57","doi-asserted-by":"crossref","unstructured":"[57]  Gould TRL,Brunette DM,Westsury L. The attachment          mechanism of epithelial cells to titanium in vitro. J Periodontal Res. 1981;16:611\u20136.          https:\/\/doi.org\/10.1111\/j.1600-0765.1981.tb00999.x PMID:6460860","DOI":"10.1111\/j.1600-0765.1981.tb00999.x"},{"key":"58","doi-asserted-by":"publisher","unstructured":"[58]  P\u00f6ll\u00e4nen MT,Salonen JI,Uitto VJ. Structure and          function of the tooth\u2013epithelial interface in health and disease. Periodontol 2000.          2003;31:12\u201331. https:\/\/doi.org\/10.1034\/j.1600-0757.2003.03102.x          PMID:12656993","DOI":"10.1034\/j.1600-0757.2003.03102.x"},{"key":"59","doi-asserted-by":"publisher","unstructured":"[59]  Abrahamsson I,Berglundh T,Glantz PO,Lindhe J.          The mucosal attachment at different abutments. An experimental study in dogs. J Clin          Periodontol. 1998;25:721\u20137. https:\/\/doi.org\/10.1111\/j.1600-051X.1998.tb02513.x          PMID:9763327","DOI":"10.1111\/j.1600-051X.1998.tb02513.x"},{"key":"60","doi-asserted-by":"publisher","unstructured":"[60]  Rousselle P,Beck K. Laminin 332 processing          impacts cellular behavior. Cell Adh Migr. 2013;7:122\u201334. https:\/\/doi.org\/10.4161\/cam.23132          PMID:23263634","DOI":"10.4161\/cam.23132"},{"key":"61","doi-asserted-by":"publisher","unstructured":"[61]  Kinumatsu T,Hashimoto S,Muramatsu T,Sasaki          H,Jung H-S,Yamada S,<i>et al.<\/i> Involvement of laminin and integrins in          adhesion and migration of junctional epithelium cells. J Periodontal Res. 2009;44:13\u201320.          https:\/\/doi.org\/10.1111\/j.1600-0765.2007.01036.x PMID:18973537","DOI":"10.1111\/j.1600-0765.2007.01036.x"},{"key":"62","doi-asserted-by":"publisher","unstructured":"[62]  Araujo MG,Lindhe J. Peri\u2010implant health. J          Periodontol. 2018;89(suppl 1):S249\u201356. https:\/\/doi.org\/10.1002\/JPER.16-0424          PMID:29926949","DOI":"10.1002\/JPER.16-0424"},{"key":"63","doi-asserted-by":"crossref","unstructured":"[63]  Buser D,Weber HP,Donath K,Fiorellini JP,Paquette          DW,Williams RC. Soft tissue reactions to non-submerged unloaded titanium implants in          beagle dogs. J Periodontol. 1992;63:225\u201335. https:\/\/doi.org\/10.1902\/jop.1992.63.3.225          PMID:1593416","DOI":"10.1902\/jop.1992.63.3.225"},{"key":"64","doi-asserted-by":"publisher","unstructured":"[64]  Berglundh T,Lindhe J,Jonsson K,Ericsson I. The          topography of the vascular systems in the periodontal and peri\u2010implant tissues in the dog.          J Clin Periodontol. 1994;21:189\u201393. https:\/\/doi.org\/10.1111\/j.1600-051X.1994.tb00302.x          PMID:8157772","DOI":"10.1111\/j.1600-051X.1994.tb00302.x"},{"key":"65","doi-asserted-by":"publisher","unstructured":"[65]  Salvi GE,Aglietta M,Eick S,Sculean A,Lang          NP,Ramseier CA. Reversibility of experimental peri\u2010implant mucositis compared with          experimental gingivitis in humans. Clin Oral Implants Res. 2012;23:182\u201390.          https:\/\/doi.org\/10.1111\/j.1600-0501.2011.02220.x PMID:21806683","DOI":"10.1111\/j.1600-0501.2011.02220.x"},{"key":"66","doi-asserted-by":"publisher","unstructured":"[66]  Okabe E,Ishihara Y,Kikuchi T,Izawa A,Kobayashi          S,Goto H,<i>et al.<\/i> Adhesion properties of human oral epithelial-derived          cells to zirconia. Clin Implant Dent Relat Res. 2016;18:906\u201316.          https:\/\/doi.org\/10.1111\/cid.12369 PMID:26245469","DOI":"10.1111\/cid.12369"},{"key":"67","doi-asserted-by":"publisher","unstructured":"[67]  Riivari S,N\u00e4rv\u00e4 E,Kangasniemi I,Willberg J,N\u00e4rhi          T. Epithelial cell attachment and adhesion protein expression on novel in sol TIO 2 coated          zirconia and titanium alloy surfaces. J Biomed Mater Res B Appl Biomater.          2022;110:2533\u201341. https:\/\/doi.org\/10.1002\/jbm.b.35111 PMID:35730701","DOI":"10.1002\/jbm.b.35111"},{"key":"68","doi-asserted-by":"publisher","unstructured":"[68]  Zheng Z,Ao X,Xie P,Zheng X,Lee K,Chen W.          Nonthermal plasma brush treatment on titanium and zirconia to improve periabutment          epithelium formation. ACS Biomater Sci Eng. 2021;7:5039\u201347.          https:\/\/doi.org\/10.1021\/acsbiomaterials.1c00895 PMID:34637254","DOI":"10.1021\/acsbiomaterials.1c00895"},{"key":"69","doi-asserted-by":"publisher","unstructured":"[69]  Furuhashi A,Ayukawa Y,Atsuta I,Rakhmatia          YD,Koyano K. Soft tissue interface with various kinds of implant abutment materials. J          Clin Med. 2021;10:2386. https:\/\/doi.org\/10.3390\/jcm10112386 PMID:34071480","DOI":"10.3390\/jcm10112386"},{"key":"70","doi-asserted-by":"publisher","unstructured":"[70]  Ayukawa Y,Atsuta I,Moriyama Y,Jinno Y,Koyano K.          Localization of integrin beta-4 subunit at soft tissue-titanium or zirconia interface. J          Clin Med. 2020;9:3331. https:\/\/doi.org\/10.3390\/jcm9103331 PMID:33080772","DOI":"10.3390\/jcm9103331"},{"key":"71","doi-asserted-by":"publisher","unstructured":"[71]  Gheisarifar M,Thompson GA,Drago C,Tabatabaei          F,Rasoulianboroujeni M. In vitro study of surface alterations to polyetheretherketone and          titanium and their effect upon human gingival fibroblasts. J Prosthet Dent.          2021;125:155\u201364. https:\/\/doi.org\/10.1016\/j.prosdent.2019.12.012          PMID:32081352","DOI":"10.1016\/j.prosdent.2019.12.012"},{"key":"72","doi-asserted-by":"publisher","unstructured":"[72]  Saad A,Penaloza Arias C,Wang M,ElKashty          O,Brambilla D,Tamimi F,<i>et al.<\/i> Biomimetic strategy to enhance epithelial          cell viability and spreading on PEEK implants. ACS Biomater Sci Eng. 2022;8:5129\u201344.          https:\/\/doi.org\/10.1021\/acsbiomaterials.2c00764 PMID:36453830","DOI":"10.1021\/acsbiomaterials.2c00764"},{"key":"73","doi-asserted-by":"publisher","unstructured":"[73]  Omatsu K,Yamawaki I,Taguchi Y,Tsumori          N,Hashimoto Y,Umeda M. Surface modification affects human gingival epithelial cell          behavior on polyetheretherketone surfaces. Dent Mater J. 2024;43:191\u20139.          https:\/\/doi.org\/10.4012\/dmj.2023-196 PMID:38246630","DOI":"10.4012\/dmj.2023-196"},{"key":"74","doi-asserted-by":"publisher","unstructured":"[74]  Wang L,He S,Wu X,Liang S,Mu Z,Wei J,<i>et            al.<\/i> Polyetheretherketone\/nano-fluorohydroxyapatite composite with antimicrobial          activity and osseointegration properties. Biomaterials. 2014;35:6758\u201375.          https:\/\/doi.org\/10.1016\/j.biomaterials.2014.04.085 PMID:24835045","DOI":"10.1016\/j.biomaterials.2014.04.085"},{"key":"75","doi-asserted-by":"publisher","unstructured":"[75]  Chen T,Jinno Y,Atsuta I,Tsuchiya A,Obinata          S,Iimori R,<i>et al.<\/i> Synergistic effect of nano strontium titanate coating          and ultraviolet C photofunctionalization on osteogenic performance and soft tissue sealing          of poly(ether-ether-ketone). ACS Biomater Sci Eng. 2024;10:825\u201337.          https:\/\/doi.org\/10.1021\/acsbiomaterials.3c01684 PMID:38267012","DOI":"10.1021\/acsbiomaterials.3c01684"},{"key":"76","doi-asserted-by":"publisher","unstructured":"[76]  Chen T,Jinno Y,Atsuta I,Tsuchiya A,Stocchero          M,Bressan E,<i>et al.<\/i> Current surface modification strategies to improve the          binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft          tissue: A literature review. J Prosthodont Res. 2022;67:337\u201347.          https:\/\/doi.org\/10.2186\/jpr.JPR_D_22_00138 PMID:36372438","DOI":"10.2186\/jpr.JPR_D_22_00138"},{"key":"77","doi-asserted-by":"publisher","unstructured":"[77]  Nikoloudaki G. Functions of matricellular          proteins in dental tissues and their emerging roles in orofacial tissue development,          maintenance, and disease. Int J Mol Sci. 2021;22:6626.          https:\/\/doi.org\/10.3390\/ijms22126626 PMID:34205668","DOI":"10.3390\/ijms22126626"},{"key":"78","doi-asserted-by":"publisher","unstructured":"[78]  Chaudhry SS,Cain SA,Morgan A,Dallas          SL,Shuttleworth CA,Kielty CM. Fibrillin-1 regulates the bioavailability of TGF\u03b21. J Cell          Biol. 2007;176:355\u201367. https:\/\/doi.org\/10.1083\/jcb.200608167          PMID:17242066","DOI":"10.1083\/jcb.200608167"},{"key":"79","doi-asserted-by":"crossref","unstructured":"[79]  Esposito M,Hirsch JM,Lekholm U,Thomsen P.          Biological factors contributing to failures of osseointegrated oral implants, (II).          Etiopathogenesis. Eur J Oral Sci. 1998;106:721\u201364.          https:\/\/doi.org\/10.1046\/j.0909-8836..t01-6-.x PMID:9672097","DOI":"10.1046\/j.0909-8836..t01-6-.x"},{"key":"80","doi-asserted-by":"crossref","unstructured":"[80]  Franco C,Patricia HR,Timo S,Claudia B,Marcela H.          Matrix metalloproteinases as regulators of periodontal inflammation. Int J Mol Sci.          2017;18:440. https:\/\/doi.org\/10.3390\/ijms18020440 PMID:28218665","DOI":"10.3390\/ijms18020440"},{"key":"81","doi-asserted-by":"publisher","unstructured":"[81]  Sun J,Ding Q,Chen Y,Li J,Wang Z,Wei Z,<i>et            al.<\/i> Effects and underlying mechanism of micro-nano-structured zirconia surfaces          on biological behaviors of human gingival fibroblasts under inflammatory conditions. Acta          Biomater. 2024;183:356\u201370. https:\/\/doi.org\/10.1016\/j.actbio.2024.05.031          PMID:38768742","DOI":"10.1016\/j.actbio.2024.05.031"},{"key":"82","doi-asserted-by":"publisher","unstructured":"[82]  Lyu Z,Zhao Y,Huo S,Wang F,Meng X,Yuan            Z,<i>et al.<\/i> Mussel-inspired dopamine-CuII coated polyetheretherketone          surface with direct and immunomodulatory effect to facilitate osteogenesis, angiogenesis,          and antibacterial ability. Mater Des. 2022;222:111069.          https:\/\/doi.org\/10.1016\/j.matdes.2022.111069","DOI":"10.1016\/j.matdes.2022.111069"},{"key":"83","doi-asserted-by":"crossref","unstructured":"[83]  Nogueira-Filho G,Pesun I,Isaak-Ploegman          C,Wijegunasinghe M,Wierzbicki T,McCulloch CA. Longitudinal comparison of cytokines in          peri-implant fluid and gingival crevicular fluid in healthy mouths. J Periodontol.          2014;85:1582\u20138. https:\/\/doi.org\/10.1902\/jop.2014.130642 PMID:24835419","DOI":"10.1902\/jop.2014.130642"},{"key":"84","doi-asserted-by":"publisher","unstructured":"[84]  Ghassib I,Chen Z,Zhu J,Wang HL. Use of IL\u20101 \u03b2,          IL\u20106, TNF\u2010\u03b1, and MMP\u20108 biomarkers to distinguish peri\u2010implant diseases: A systematic          review and meta\u2010analysis. Clin Implant Dent Relat Res. 2019;21:190\u2013207.          https:\/\/doi.org\/10.1111\/cid.12694 PMID:30508312","DOI":"10.1111\/cid.12694"},{"key":"85","doi-asserted-by":"crossref","unstructured":"[85]  Berglundh T,Armitage G,Araujo MG,Avila-Ortiz          G,Blanco J,Camargo PM,<i>et al.<\/i> Peri-implant diseases and conditions:          consensus report of workgroup 4 of the 2017 World Workshop on the Classification of          Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89(suppl          1):S313\u20138. https:\/\/doi.org\/10.1002\/JPER.17-0739 PMID:29926955","DOI":"10.1002\/JPER.17-0739"},{"key":"86","doi-asserted-by":"publisher","unstructured":"[86]  Lee CT,Huang YW,Zhu L,Weltman R. Prevalences of          peri-implantitis and peri-implant mucositis: Systematic review and meta-analysis. J Dent.          2017;62:1\u201312. https:\/\/doi.org\/10.1016\/j.jdent.2017.04.011 PMID:28478213","DOI":"10.1016\/j.jdent.2017.04.011"},{"key":"87","doi-asserted-by":"publisher","unstructured":"[87]  Schwarz F,Derks J,Monje A,Wang HL.          Peri\u2010implantitis. J Clin Periodontol. 2018;45(suppl 20):S246\u201366.          https:\/\/doi.org\/10.1111\/jcpe.12954 PMID:29926484","DOI":"10.1111\/jcpe.12954"},{"key":"88","doi-asserted-by":"publisher","unstructured":"[88]  Ramburrun P,Pringle NA,Dube A,Adam RZ,D\u2019Souza          S,Aucamp M. Recent advances in the development of antimicrobial and antifouling          biocompatible materials for dental applications. Materials (Basel). 2021;14:3167.          https:\/\/doi.org\/10.3390\/ma14123167 PMID:34207552","DOI":"10.3390\/ma14123167"},{"key":"89","doi-asserted-by":"publisher","unstructured":"[89]  Atsuta I,Ayukawa Y,Furuhashi A,Narimatsu I,Kondo          R,Oshiro W,<i>et al.<\/i> Epithelial sealing effectiveness against titanium or          zirconia implants surface. J Biomed Mater Res A. 2019;107:1379\u201385.          https:\/\/doi.org\/10.1002\/jbm.a.36651 PMID:30724473","DOI":"10.1002\/jbm.a.36651"},{"key":"90","doi-asserted-by":"publisher","unstructured":"[90]  Liu M,Zhou J,Yang Y,Zheng M,Yang J,Tan J.          Surface modification of zirconia with polydopamine to enhance fibroblast response and          decrease bacterial activity in vitro : A potential technique for soft tissue engineering          applications. Colloids Surf B Biointerfaces. 2015;136:74\u201383.          https:\/\/doi.org\/10.1016\/j.colsurfb.2015.06.047 PMID:26363269","DOI":"10.1016\/j.colsurfb.2015.06.047"},{"key":"91","doi-asserted-by":"publisher","unstructured":"[91]  Wen C,Muhetaer HJ,Gao Z,Wu J. Dual response of          fibroblasts viability and Porphyromonas gingivalis adhesion on nanostructured zirconia          abutment surfaces. J Biomed Mater Res A. 2022;110:1645\u201354.          https:\/\/doi.org\/10.1002\/jbm.a.37414 PMID:35676876","DOI":"10.1002\/jbm.a.37414"},{"key":"92","doi-asserted-by":"publisher","unstructured":"[92]  Yang Z,Liu M,Yang Y,Zheng M,Yang Y,Liu            X,<i>et al.<\/i> Biofunctionalization of zirconia with cell-adhesion peptides          via polydopamine crosslinking for soft tissue engineering: effects on the biological          behaviors of human gingival fibroblasts and oral bacteria. RSC Adv. 2020;10:6200\u201312.          https:\/\/doi.org\/10.1039\/C9RA08575K PMID:35495985","DOI":"10.1039\/C9RA08575K"},{"key":"93","doi-asserted-by":"publisher","unstructured":"[93]  Xu X,Li Y,Wang L,Li Y,Pan J,Fu X,<i>et            al.<\/i> Triple-functional polyetheretherketone surface with enhanced bacteriostasis          and anti-inflammatory and osseointegrative properties for implant application.          Biomaterials. 2019;212:98\u2013114. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.05.014          PMID:31112825","DOI":"10.1016\/j.biomaterials.2019.05.014"},{"key":"94","doi-asserted-by":"publisher","unstructured":"[94]  Tang K,Luo ML,Zhou W,Niu LN,Chen JH,Wang F. The          integration of peri-implant soft tissues around zirconia abutments: challenges and          strategies. Bioact Mater. 2023;27:348\u201361. https:\/\/doi.org\/10.1016\/j.bioactmat.2023.04.009          PMID:37180640","DOI":"10.1016\/j.bioactmat.2023.04.009"},{"key":"95","doi-asserted-by":"publisher","unstructured":"[95]  Jin S,Yu Y,Zhang T,Xie D,Zheng Y,Wang            C,<i>et al.<\/i> Surface modification strategies to reinforce the soft tissue          seal at transmucosal region of dental implants. Bioact Mater. 2024;42:404\u201332.          https:\/\/doi.org\/10.1016\/j.bioactmat.2024.08.042 PMID:39308548","DOI":"10.1016\/j.bioactmat.2024.08.042"},{"key":"96","doi-asserted-by":"publisher","unstructured":"[96]  Ayyadanveettil P,Thavakkara V,Latha N,Pavanan          M,Saraswathy A,Kuruniyan MS. Randomized clinical trial of zirconia and          polyetheretherketone implant abutments for single-tooth implant restorations: A 5-year          evaluation. J Prosthet Dent. 2022;128:1275\u201381.          https:\/\/doi.org\/10.1016\/j.prosdent.2021.02.037 PMID:33933267","DOI":"10.1016\/j.prosdent.2021.02.037"},{"key":"97","doi-asserted-by":"publisher","unstructured":"[97]  Leong A,De Kok I,Mendon\u00e7a D,Cooper L. Molecular          assessment of human peri-implant mucosal healing at laser-modified and machined titanium          abutments. Int J Oral Maxillofac Implants. 2018;33:895\u2013904.          https:\/\/doi.org\/10.11607\/jomi.6367 PMID:30025007","DOI":"10.11607\/jomi.6367"},{"key":"98","doi-asserted-by":"publisher","unstructured":"[98]  Hall J,Neilands J,Davies JR,Ekestubbe A,Friberg          B. A randomized, controlled, clinical study on a new titanium oxide abutment surface for          improved healing and soft tissue health. Clin Implant Dent Relat Res. 2019;21(suppl          1):55\u201368. https:\/\/doi.org\/10.1111\/cid.12749 PMID:30859691","DOI":"10.1111\/cid.12749"},{"key":"99","doi-asserted-by":"publisher","unstructured":"[99]  Yossri D,Din NHKE,Afifi NS,Adel-Khattab D. Soft          tissue response to titanium healing abutments treated by Er: YAG laser or plasma spray: A          randomized controlled feasibility clinical study with SEM and histological analysis. Clin          Implant Dent Relat Res. 2025;27:e13373. https:\/\/doi.org\/10.1111\/cid.13373          PMID:39410747","DOI":"10.1111\/cid.13373"},{"key":"100","doi-asserted-by":"publisher","unstructured":"[100]  Wang M,Zhang S,Chen L,Zou H,Wang Y,Xia H. Early          soft tissue response to zirconium oxide and titanium healing abutments in vivo: a study in          dogs. BMC Oral Health. 2021;21:416. https:\/\/doi.org\/10.1186\/s12903-021-01748-0          PMID:34429083","DOI":"10.1186\/s12903-021-01748-0"},{"key":"101","doi-asserted-by":"publisher","unstructured":"[101]  Sampatanukul T,Serichetaphongse P,Pimkhaokham A.          Histological evaluations and inflammatory responses of different dental implant abutment          materials: A human histology pilot study. Clin Implant Dent Relat Res. 2018;20:160\u20139.          https:\/\/doi.org\/10.1111\/cid.12562 PMID:29181880","DOI":"10.1111\/cid.12562"},{"key":"102","doi-asserted-by":"publisher","unstructured":"[102]  Pansani TN,Basso FG,de Souza Costa CA. In vitro          effects of photobiomodulation applied to gingival fibroblasts cultured on titanium and          zirconia surfaces and exposed to LPS from Escherichia coli. Lasers Med Sci.          2020;35:2031\u20138. https:\/\/doi.org\/10.1007\/s10103-020-03062-7 PMID:32533469","DOI":"10.1007\/s10103-020-03062-7"},{"key":"103","doi-asserted-by":"publisher","unstructured":"[103]  Valantijiene V,Mazeikiene A,Alkimavicius          J,Linkeviciene L,Alkimaviciene E,Linkevicius T. Clinical and immunological evaluation of          peri\u2010implant tissues around ultra\u2010polished and conventionally\u2010polished zirconia abutments.          A 1\u2010year follow\u2010up randomized clinical trial. J Prosthodont. 2023;32:392\u2013400.          https:\/\/doi.org\/10.1111\/jopr.13670 PMID:36896861","DOI":"10.1111\/jopr.13670"},{"key":"104","doi-asserted-by":"publisher","unstructured":"[104]  Rigolin MSM,Barbugli PA,Jorge JH,Reis MRD,Adabo          GL,Casemiro LA,<i>et al.<\/i> Effect of the aging of titanium and zirconia          abutment surfaces on the viability, adhesion, and proliferation of cells and the adhesion          of microorganisms. J Prosthet Dent. 2019;122:564.e1\u201310.          https:\/\/doi.org\/10.1016\/j.prosdent.2019.08.027 PMID:31791536","DOI":"10.1016\/j.prosdent.2019.08.027"},{"key":"105","unstructured":"[105]  Esfahanizadeh N,Mirmalek SP,Bahador          A,Daneshparvar H,Akhoundi N,Pourhajibagher M. Formation of biofilm on various implant          abutment materials. Gen Dent. 2018;66:39\u201344. PMID:30188855"},{"key":"106","doi-asserted-by":"publisher","unstructured":"[106]  Xing R,Lyngstadaas SP,Ellingsen JE,Taxt-Lamolle          S,Haugen HJ. The influence of surface nanoroughness, texture and chemistry of TiZr implant          abutment on oral biofilm accumulation. Clin Oral Implants Res. 2015;26:649\u201356.          https:\/\/doi.org\/10.1111\/clr.12354 PMID:25906328","DOI":"10.1111\/clr.12354"},{"key":"107","doi-asserted-by":"publisher","unstructured":"[107]  do Nascimento C,Pita MS,Santos ES,Monesi          N,Pedrazzi V,de Albuquerque Junior RF,<i>et al.<\/i> Microbiome of titanium and          zirconia dental implants abutments. Dent Mater. 2016;32:93\u2013101.          https:\/\/doi.org\/10.1016\/j.dental.2015.10.014 PMID:26616687","DOI":"10.1016\/j.dental.2015.10.014"},{"key":"108","doi-asserted-by":"publisher","unstructured":"[108]  de Avila ED,Vergani CE,Mollo Junior FA,Junior          MJ,Shi W,Lux R. Effect of titanium and zirconia dental implant abutments on a cultivable          polymicrobial saliva community. J Prosthet Dent. 2017;118:481\u20137.          https:\/\/doi.org\/10.1016\/j.prosdent.2017.01.010 PMID:28343672","DOI":"10.1016\/j.prosdent.2017.01.010"},{"key":"109","doi-asserted-by":"publisher","unstructured":"[109]  Raffaini FC,Freitas AR,Silva TSO,Cavagioni          T,Oliveira JF,Albuquerque Junior RF,<i>et al.<\/i> Genome analysis and clinical          implications of the bacterial communities in early biofilm formation on dental implants          restored with titanium or zirconia abutments. Biofouling. 2018;34:173\u201382.          https:\/\/doi.org\/10.1080\/08927014.2017.1417396 PMID:29336173","DOI":"10.1080\/08927014.2017.1417396"},{"key":"110","doi-asserted-by":"publisher","unstructured":"[110]  Bottino MA,Pereira SMB,Amaral M,Milhan          NVM,Pereira CA,Camargo SEA,<i>et al.<\/i> Streptococcus mutans biofilm formation          and cell viability on polymer-infiltrated ceramic and yttria-stabilized polycrystalline          zirconium dioxide ceramic. Oper Dent. 2019;44:E271\u20138. https:\/\/doi.org\/10.2341\/18-278-L          PMID:31373891","DOI":"10.2341\/18-278-L"},{"key":"111","doi-asserted-by":"publisher","unstructured":"[111]  Yang Y,Zheng M,Yang Y,Li J,Su YF,Li            HP,<i>et al.<\/i> Inhibition of bacterial growth on zirconia abutment with a          helium cold atmospheric plasma jet treatment. Clin Oral Investig. 2020;24:1465\u201377.          https:\/\/doi.org\/10.1007\/s00784-019-03179-2 PMID:31940064","DOI":"10.1007\/s00784-019-03179-2"},{"key":"112","doi-asserted-by":"publisher","unstructured":"[112]  Meier D,Astasov-Frauenhoffer M,Waltimo T,Zaugg          LK,Rohr N,Zitzmann NU. Biofilm formation on metal alloys and coatings, zirconia, and          hydroxyapatite as implant materials in vivo. Clin Oral Implants Res. 2023;34:1118\u201326.          https:\/\/doi.org\/10.1111\/clr.14146 PMID:37489537","DOI":"10.1111\/clr.14146"},{"key":"113","doi-asserted-by":"publisher","unstructured":"[113]  Peng M,Chuan JL,Zhao G,Fu Q. Construction of          silver-coated high translucent zirconia implanting abutment material and its property of          antibacterial. Artif Cells Nanomed Biotechnol. 2023;51:441\u201352.          https:\/\/doi.org\/10.1080\/21691401.2023.2244013 PMID:37594201","DOI":"10.1080\/21691401.2023.2244013"},{"key":"114","doi-asserted-by":"publisher","unstructured":"[114]  Brunello G,Brun P,Gardin C,Ferroni L,Bressan          E,Meneghello R,<i>et al.<\/i> Biocompatibility and antibacterial properties of          zirconium nitride coating on titanium abutments: An in vitro study. PLoS One.          2018;13:e0199591. https:\/\/doi.org\/10.1371\/journal.pone.0199591          PMID:29944716","DOI":"10.1371\/journal.pone.0199591"},{"key":"115","doi-asserted-by":"crossref","unstructured":"[115]  Heuer W,Stiesch M,Abraham WR. Microbial          diversity of supra- and subgingival biofilms on freshly colonized titanium implant          abutments in the human mouth. Eur J Clin Microbiol Infect Dis. 2011;30:193\u2013200.          https:\/\/doi.org\/10.1007\/s10096-010-1068-y PMID:20931254","DOI":"10.1007\/s10096-010-1068-y"},{"key":"116","doi-asserted-by":"publisher","unstructured":"[116]  Dorkhan M,Hall J,Uvdal P,Sandell A,Svens\u00e4ter          G,Davies JR. Crystalline anatase-rich titanium can reduce adherence of oral streptococci.          Biofouling. 2014;30:751\u20139. https:\/\/doi.org\/10.1080\/08927014.2014.922962          PMID:24881929","DOI":"10.1080\/08927014.2014.922962"},{"key":"117","doi-asserted-by":"publisher","unstructured":"[117]  Xavier JG,Geremias TC,Montero JFD,Vahey          BR,Benfatti CAM,Souza JCM,<i>et al.<\/i> Lactam inhibiting Streptococcus mutans          growth on titanium. Mater Sci Eng C. 2016;68:837\u201341.          https:\/\/doi.org\/10.1016\/j.msec.2016.07.013 PMID:27524086","DOI":"10.1016\/j.msec.2016.07.013"},{"key":"118","doi-asserted-by":"publisher","unstructured":"[118]  Matos AO,Ricomini-Filho AP,Beline T,Ogawa          ES,Costa-Oliveira BE,de Almeida AB,<i>et al.<\/i> Three-species biofilm model          onto plasma-treated titanium implant surface. Colloids Surf B Biointerfaces.          2017;152:354\u201366. https:\/\/doi.org\/10.1016\/j.colsurfb.2017.01.035          PMID:28131960","DOI":"10.1016\/j.colsurfb.2017.01.035"},{"key":"119","doi-asserted-by":"publisher","unstructured":"[119]  Kheur S,Singh N,Bodas D,Rauch JY,Jambhekar          S,Kheur M,<i>et al.<\/i> Nanoscale silver depositions inhibit microbial          colonization and improve biocompatibility of titanium abutments. Colloids Surf B          Biointerfaces. 2017;159:151\u20138. https:\/\/doi.org\/10.1016\/j.colsurfb.2017.07.079          PMID:28783506","DOI":"10.1016\/j.colsurfb.2017.07.079"},{"key":"120","doi-asserted-by":"publisher","unstructured":"[120]  Shokeen B,Zamani L,Zadmehr S,Pouraghaie S,Ozawa          R,Yilmaz B,<i>et al.<\/i> Surface characterization and assessment of biofilm          formation on two titanium-based implant coating materials. Front Dent Med. 2021;2:695417.          https:\/\/doi.org\/10.3389\/fdmed.2021.695417","DOI":"10.3389\/fdmed.2021.695417"},{"key":"121","doi-asserted-by":"publisher","unstructured":"[121]  Morin JLP,Dubey N,Luong-Van EK,Yu B,Sabino          CF,Silikas N,<i>et al.<\/i> Graphene nanocoating on titanium maintains structural          and antibiofilm properties post-sterilization. Dent Mater. 2025;41:7\u201315.          https:\/\/doi.org\/10.1016\/j.dental.2024.10.009 PMID:39455326","DOI":"10.1016\/j.dental.2024.10.009"},{"key":"122","doi-asserted-by":"publisher","unstructured":"[122]  Dabbah K,Perelshtein I,Gedanken A,Houri-Haddad          Y,Feuerstein O. Effects of a ZnCuO-nanocoated Ti-6Al-4V surface on bacterial and host          cells. Materials (Basel). 2022;15:2514. https:\/\/doi.org\/10.3390\/ma15072514          PMID:35407847","DOI":"10.3390\/ma15072514"},{"key":"123","doi-asserted-by":"publisher","unstructured":"[123]  Xue Y,Zhang L,Liu F,Kong L,Ma D,Han Y. Fluoride          releasing photothermal responsive TiO2 matrices for antibiosis, biosealing and bone          regeneration. J Control Release. 2023;363:657\u201369.          https:\/\/doi.org\/10.1016\/j.jconrel.2023.10.016 PMID:37832724","DOI":"10.1016\/j.jconrel.2023.10.016"},{"key":"124","doi-asserted-by":"publisher","unstructured":"[124]  Salaie RN,Hassan PA,Meran ZD,Hamad SA.          Antibacterial activity of dissolved silver fractions released from silver-coated titanium          dental implant abutments: A study on Streptococcus mutans biofilm formation. Antibiotics          (Basel). 2023;12:1097. https:\/\/doi.org\/10.3390\/antibiotics12071097          PMID:37508193","DOI":"10.3390\/antibiotics12071097"},{"key":"125","doi-asserted-by":"publisher","unstructured":"[125]  Maeno M,Lee C,Kim DM,Da Silva J,Nagai S,Sugawara            S,<i>et al.<\/i> Function of platelet-induced epithelial attachment at titanium          surfaces inhibits microbial colonization. J Dent Res. 2017;96:633\u20139.          https:\/\/doi.org\/10.1177\/0022034516688888 PMID:28086031","DOI":"10.1177\/0022034516688888"},{"key":"126","doi-asserted-by":"publisher","unstructured":"[125]  Maeno M,Lee C,Kim DM,Da Silva J,Nagai S,Sugawara            S,<i>et al.<\/i> Function of platelet-induced epithelial attachment at titanium          surfaces inhibits microbial colonization. J Dent Res. 2017;96:633\u20139.          https:\/\/doi.org\/10.1177\/0022034516688888 PMID:28086031","DOI":"10.1177\/0022034516688888"},{"key":"127","doi-asserted-by":"publisher","unstructured":"[127]  Kobayashi M,Abdulmajeed AA,Moon J,Shahramian          K,Punkkinen R,Shimada J,<i>et al.<\/i> The effect of Ultraviolet treatment on          TiO2 nanotubes: A study of surface characteristics, bacterial adhesion, and gingival          fibroblast response. 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