{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:46:29Z","timestamp":1791431189122,"version":"4.3.3"},"reference-count":0,"publisher":"International Institute of Anticancer Research","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anticancer Res"],"accepted":{"date-parts":[[2026,3,4]]},"published-print":{"date-parts":[[2026,5]]},"DOI":"10.21873\/anticanres.18130","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:40:33Z","timestamp":1777376433000},"page":"2455-2465","source":"Crossref","is-referenced-by-count":1,"title":["Proinsulin Promotes Tumor Development in the PANC-1 Pancreatic Adenocarcinoma Cell Line"],"prefix":"10.21873","volume":"46","author":[{"given":"TOMONORI","family":"TSUYAMA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANCHEN","family":"DONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKENARI","family":"SATO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROHISA","family":"OKABE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROMITSU","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAAKI","family":"IWATSUKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUYA","family":"YAMAGATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9336","published-online":{"date-parts":[[2026,4,28]]},"container-title":["Anticancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.21873\/anticanres.18130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:30:42Z","timestamp":1791225042000},"score":1,"resource":{"primary":{"URL":"http:\/\/ar.iiarjournals.org\/lookup\/doi\/10.21873\/anticanres.18130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,4,28]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.21873\/anticanres.18130"],"URL":"https:\/\/doi.org\/10.21873\/anticanres.18130","relation":{},"ISSN":["0250-7005","1791-7530"],"issn-type":[{"value":"0250-7005","type":"print"},{"value":"1791-7530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}