{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:51:42Z","timestamp":1790311902527,"version":"4.1.0"},"reference-count":0,"publisher":"International Institute of Anticancer Research","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CDP"],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:p>Background\/Aim: To investigate the association between androgen deprivation therapy (ADT) and changes in the estimated glomerular filtration rate (eGFR) in male Japanese patients with prostate cancer, based on post-hoc analysis of data from a previous prospective study. Patients and Methods: Among 103 patients with prostate cancer in whom renal function changes were tracked over 5 years, 88 were divided into a group who completed ADT within 3 years (short ADT group; n=47) and a group who continued with ADT for more than 5 years (continuous ADT group; n=41). We compared the groups in terms of the eGFR, calculated based on age and serum creatinine (mg\/dl) before ADT initiation and every other year over the next 5 years. Results: The eGFR decreased by 4.91 and 2.89 ml\/min in the short and continuous ADT groups, respectively, over the 5-year period following ADT initiation. The respective decreases in the eGFR were 0.98 and 0.58 ml\/min\/year. No significant difference in the eGFR was observed between the two groups at any measurement point. Patients treated with ADT showed a decrease in the eGFR of 0.58-0.98 ml\/min\/year over a 5-year period, which is about twice as high as that of normal Japanese males. No significant difference in the eGFR by ADT duration was observed. Conclusion: The eGFR decreased by 0.58-0.98 ml\/min\/year in our ADT patients, which was about twice as high as the rate of decrease in normal Japanese males, and approximately the same as in urine protein-positive male patients. We suggest that a large decrease in the eGFR may not play a role in the development of acute kidney injury. In addition, the duration of ADT does not appear to have a significant effect on the eGFR.<\/jats:p>","DOI":"10.21873\/cdp.10160","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T14:51:16Z","timestamp":1668005476000},"page":"686-690","source":"Crossref","is-referenced-by-count":4,"title":["Changes in Renal Function of Patients With Prostate Cancer: Focus on Androgen Deprivation Therapy"],"prefix":"10.21873","volume":"2","author":[{"given":"YOSHIYUKI","family":"MIYAZAWA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHITAKA","family":"SEKINE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEIJI","family":"ARAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASASHI","family":"NOMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDEKAZU","family":"KOIKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROSHI","family":"MATSUI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUHIRO","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9336","published-online":{"date-parts":[[2022,11,3]]},"container-title":["Cancer Diagnosis &amp; Prognosis"],"original-title":[],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T12:16:11Z","timestamp":1724933771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cancerdiagnosisprognosis.org\/article\/155\/changes-in-renal-function-of-patients-with-prostate-cancer-focus-on-androgen-deprivation-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,3]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,11,3]]},"published-print":{"date-parts":[[2022,11,3]]}},"URL":"https:\/\/doi.org\/10.21873\/cdp.10160","relation":{},"ISSN":["2732-7787"],"issn-type":[{"value":"2732-7787","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,3]]}}}