{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:34:35Z","timestamp":1785537275109,"version":"3.56.0"},"reference-count":0,"publisher":"International Institute of Anticancer Research","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CDP"],"published-print":{"date-parts":[[2022,12,30]]},"abstract":"<jats:p>Background\/Aim: To identify predictors of adverse gastrointestinal (GI) events related to stereotactic body radiation therapy (SBRT) for liver tumors. Patients and Methods: We retrospectively analyzed 56 patients who underwent SBRT for liver tumors at our institution between 2016 and 2021. The \u03b1\/\u03b2 ratio of the GI tract (stomach, duodenum, and large intestine) was assumed to be 3 Gy in the Linear-Quadratic model (LQ model). The dose to the GI tract, that is, the biologically effective dose 3 (BED3) was converted to a 2 Gy equivalent dose (Gy2\/3=2 Gy equivalent dose, \u03b1\/\u03b2=3). Using this 2 Gy equivalent dose, predictors of adverse GI events of Grade 2 or higher were investigated. Results: The median observation period was 10 months (0-40 months) and median age was 77 years (range=29-93 years). Forty-three of the 56 patients had hepatocellular carcinoma and the other 13 had metastatic liver tumors. Tumors were irradiated with 30-54 Gy\/5-18 fractions of planning target volume D95% prescription (80% isodose). Eight of the 56 patients had Grade 2 or higher adverse GI events. By univariate analysis, GI D1cc, Dmax, V20, V25, V30, and V35 were all significant predictors of Grade 2 or higher adverse GI events. Among these, gastrointestinal V35 was the most significant predictor of Grade 2 or higher adverse GI events. Conclusion: For SBRT of liver tumors, GI V35 was the best predictor of Grade 2 or higher adverse GI events.<\/jats:p>","DOI":"10.21873\/cdp.10184","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T11:30:37Z","timestamp":1672399837000},"page":"91-95","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Adverse Gastrointestinal Events After Stereotactic Body Radiation Therapy for Liver Tumors"],"prefix":"10.21873","volume":"3","author":[{"given":"KENTA","family":"OHMATSU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YAICHIRO","family":"HASHIMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHIGEHIKO","family":"KURIBAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHIE","family":"TORAMATSU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KIWOO","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAWA","family":"KONO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MIKI","family":"KAWANISHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KUMIKO","family":"KARASAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9336","published-online":{"date-parts":[[2022,12,30]]},"container-title":["Cancer Diagnosis &amp; Prognosis"],"original-title":[],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T08:51:45Z","timestamp":1724921505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cancerdiagnosisprognosis.org\/article\/191\/predictors-of-adverse-gastrointestinal-events-after-stereotactic-body-radiation-therapy-for-liver-tumors"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,3]]},"published-print":{"date-parts":[[2023,1,3]]}},"URL":"https:\/\/doi.org\/10.21873\/cdp.10184","relation":{},"ISSN":["2732-7787"],"issn-type":[{"value":"2732-7787","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,30]]}}}