{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:39:56Z","timestamp":1757608796081,"version":"3.44.0"},"reference-count":0,"publisher":"International Institute of Anticancer Research","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CDP"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>Background\/Aim: Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the development of multiple tumors, including plexiform neurofibromas (PNFs), which often affect the craniofacial region and cause significant functional and aesthetic impairments. This report presents long-term surgical management of a patient with hemifacial diffuse PNF, complicated by the emergence of a rapidly enlarging midfacial tumor.\nCase Report: The patient was treated for hemifacial invasive diffuse plexiform neurofibroma. During follow-up, the patient developed a rapidly growing tumor suggesting malignant transformation. Histological analysis revealed plexiform and diffuse neurofibroma with necrosis. Defect coverage after resection was complex and required tissue replacement with a microvascular graft. In the further course, new neurofibromas developed in the oral transplant.\nConclusion: Surgical measures enable functional and aesthetic improvements despite extensive facial destruction caused by the tumor. Rapid tumor growth is a finding that requires immediate diagnosis in patients with NF1. Even in tumor-free transplants at the time of tissue transfer, (nodular) neurofibromas can develop at the recipient site.<\/jats:p>","DOI":"10.21873\/cdp.10471","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T07:22:01Z","timestamp":1756884121000},"page":"566-582","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Measures Improving Functional Limitations of the Masticatory System, Aesthetic Deficits, and Skeletal Malformations in Neurofibromatosis Type 1\u2010associated Hemifacial Diffuse Plexiform Neurofibroma Complicated by Rapidly Growing Midfacial Peripheral Nerve Sheath Tumor"],"prefix":"10.21873","volume":"5","author":[{"given":"REINHARD E.","family":"FRIEDRICH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FELIX K.","family":"KOHLRUSCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTIAN","family":"HAGEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9336","published-online":{"date-parts":[[2025,9,1]]},"container-title":["Cancer Diagnosis &amp; Prognosis"],"original-title":[],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T07:22:02Z","timestamp":1756884122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cancerdiagnosisprognosis.org\/article\/536\/surgical-measures-improving-functional-limitations-of-the-masticatory-system-aesthetic-deficits-and-skeletal-malformations-in-neurofibromatosis-type-1associated-hemifacial-diffuse-plexiform-neurofibroma-complicated-by-rapidly-growing-midfacial-peripheral-nerve-sheath-tumor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9,1]]},"published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.21873\/cdp.10471","relation":{},"ISSN":["2732-7787"],"issn-type":[{"type":"print","value":"2732-7787"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}