{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:18:23Z","timestamp":1783351103532,"version":"3.54.6"},"reference-count":0,"publisher":"International Institute of Anticancer Research","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CDP"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>Background\/Aim: \nWith the expansion of next-generation sequencing (NGS)-based hereditary cancer panels, this study aimed to: (i) identify non-BRCA predisposition genes in an index case with three different primary cancers; (ii) demonstrate the clinical utility of cascade testing via comprehensive panel NGS testing for early cancer detection in asymptomatic relatives; (iii) discuss the potential association between a co-segregating MITF variant and a family history of recurrent meningioma; and (iv) provide a practical management framework for Multilocus Inherited Neoplasia Allele Syndrome (MINAS) in the context of dual ATM+MITF carriership.\nMaterials and Methods: \nIndex patient and family members who have a history of cancer with a familial cancer pedigree were evaluated using a multigene NGS approach. Targeted sequencing was performed on the MGI DNBSEQ-G400 platform using the Twist Bioscience Hereditary Cancer Panel.\nResults: \nA germline ATM variant was identified in the index case, and ATM carrier status was confirmed in his two sons. During cascade screening, early-stage colon cancer was detected on colonoscopy in one son, while prostate cancer was diagnosed in the other. MITF carrier status was identified in three family members; among them, the index patient\u2019s sister and one nephew had a history of meningioma, and the nephew was also shown to be an ATM carrier. A history of meningioma was also present in another family member with an MITF variant.\nConclusion: \nLarge-panel NGS testing in cancer patients is transforming family-based risk management by enabling the identification of homologous recombination repair (HRR) genes (including ATM) beyond BRCA1\/2. Cascade testing via comprehensive NGS provides tangible clinical benefits by detecting malignancies early in clinically silent carriers.<\/jats:p>","DOI":"10.21873\/cdp.10574","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:51:52Z","timestamp":1783349512000},"page":"737-744","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Comprehensive Panel NGS Testing and Cascade Family Screening on Early Diagnosis of Prostate Cancer and MINAS (ATM+MITF) Management"],"prefix":"10.21873","volume":"6","author":[{"given":"\u0130REM","family":"B\u0130LGETEK\u0130N","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAHA","family":"BAHS\u0130","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUSUF","family":"BAHAP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEHMET AL\u0130","family":"ERG\u00dcN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130BRAH\u0130M","family":"G\u00dcLL\u00dc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9336","published-online":{"date-parts":[[2026,7,1]]},"container-title":["Cancer Diagnosis &amp; Prognosis"],"original-title":[],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:51:58Z","timestamp":1783349518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cancerdiagnosisprognosis.org\/article\/636\/the-impact-of-comprehensive-panel-ngs-testing-and-cascade-family-screening-on-early-diagnosis-of-prostate-cancer-and-minas-atmmitf-management"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,1]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.21873\/cdp.10574","relation":{},"ISSN":["2732-7787"],"issn-type":[{"value":"2732-7787","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}