{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:43:46Z","timestamp":1790981026238,"version":"4.1.0"},"reference-count":38,"publisher":"Japan Epidemiological Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Epidemiology"],"published-print":{"date-parts":[[2013]]},"DOI":"10.2188\/jea.je20120168","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T23:10:41Z","timestamp":1376089841000},"page":"360-370","source":"Crossref","is-referenced-by-count":101,"title":["Associations of Prenatal Mercury Exposure From Maternal Fish Consumption and Polyunsaturated Fatty Acids With Child Neurodevelopment: A Prospective Cohort Study in Italy"],"prefix":"10.2188","volume":"23","author":[{"given":"Francesca","family":"Valent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Mariuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Bin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D^|^rsquo;Anna","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darja","family":"Mazej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Tognin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janja","family":"Tratnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J","family":"McAfee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S","family":"Mulhern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Parpinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Carrozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Tamburlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Barbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"991","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Clarkson TW, Magos L, Myers GJ. The toxicology of mercury&mdash;current exposures and clinical manifestations. N Engl J Med. 2003;349:1731&ndash;7.","DOI":"10.1056\/NEJMra022471"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3109\/10408449509089885"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Amin-Zaki L, Elhassani S, Majeed MA, Clarkson TW, Doherty RA, Greenwood M. Intra-uterine methylmercury poisoning in Iraq. Pediatrics. 1974;54:587&ndash;95.","DOI":"10.1007\/978-94-011-6621-8_37"},{"key":"4","unstructured":"4. Myers GJ, Davidson PW, Cox C, Shamlaye CF, Tanner MA, Choisy O, et&nbsp;al. Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: pilot study. Neurotoxicology. 1995;16:639&ndash;52."},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(97)00097-4"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Grandjean P, White RF, Weihe P, J&oslash;rgensen PJ. Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood. Ambul Pediatr. 2003;3:18&ndash;23.","DOI":"10.1367\/1539-4409(2003)003<0018:NRCBSA>2.0.CO;2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1993.1062"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Debes F, Budtz-J&oslash;rgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol. 2006;28:536&ndash;47.","DOI":"10.1016\/j.ntt.2006.02.005"},{"key":"9","unstructured":"9. Myers GJ, Davidson PW, Shamlaye CF, Axtell CD, Cernichiari E, Choisy O, et&nbsp;al. Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study. Neurotoxicology. 1997;18:819&ndash;29."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Myers GJ, Davidson PW, Cox C, Shamlaye CF, Palumbo D, Cernichiari E, et&nbsp;al. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet. 2003;361:1686&ndash;92.","DOI":"10.1016\/S0140-6736(03)13371-5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.8.701"},{"key":"12","unstructured":"12. Davidson PW, Myers GJ, Cox C, Shamlaye C, Choisy O, Sloane-Reeves J, et&nbsp;al. Neurodevelopmental test selection, administration, and performance in the main Seychelles child development study. Neurotoxicology. 1995;16:665&ndash;76."},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.2000.4084"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Davidson PW, Sloane-Reeves J, Myers GJ, Hansen ON, Huang LS, Georger LA, et&nbsp;al. Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the Seychelles child development study. Neurotoxicology. 2008;29:453&ndash;9.","DOI":"10.1016\/j.neuro.2008.02.009"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Schoeman K, Bend JR, Hill J, Nash K, Koren G. Defining a lowest observable adverse effect hair concentrations of mercury for neurodevelopmental effects of prenatal methylmercury exposure through maternal fish consumption: a systematic review. Ther Drug Monit. 2009;31:670&ndash;82.","DOI":"10.1097\/FTD.0b013e3181bb0ea1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Innis SM. Fatty acids and early human development. Early Hum Dev. 2007;83:761&ndash;6.","DOI":"10.1016\/j.earlhumdev.2007.09.004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hibbeln JR, Davis JM, Steer C, Emmett P, Rogers I, Williams C, et&nbsp;al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet. 2007;369:578&ndash;85.","DOI":"10.1016\/S0140-6736(07)60277-3"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Oken E, Wright RO, Kleinman KP, Bellinger D, Amarasiriwardena CJ, Hu H, et&nbsp;al. Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort. Environ Health Perspect. 2005;113:1376&ndash;80.","DOI":"10.1289\/ehp.8041"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Budtz-J&oslash;rgensen E, Grandjean P, Weihe P. Separation of risks and benefits of seafood intake. Environ Health Perspect. 2007;115:323&ndash;7.","DOI":"10.1289\/ehp.9738"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Strain JJ, Davidson PW, Bonham MP, Duffy EM, Stokes-Riner A, Thurston SW, et&nbsp;al. Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study. Neurotoxicology. 2008;29:776&ndash;82.","DOI":"10.1016\/j.neuro.2008.06.002"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2010.11.003"},{"key":"22","unstructured":"22. Barbone F, Valent F, Pisa F, Daris F, Fajon V, Gibicar D, et&nbsp;al. Prenatal low level methyl mercury exposure and child development in an Italian coastal area. SMDJ. 2004;7:49&ndash;154."},{"key":"23","unstructured":"23. Valent F, Pisa F, Mariuz M, Horvat M, Gibicar D, Fajon V, et&nbsp;al. Fetal and perinatal exposure to mercury and selenium: baseline evaluation of a cohort of children in Friuli Venezia Giulia, Italy. Epidemiol Prev. 2011;35:33&ndash;42."},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20120030"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.109579"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Decarli A, Franceschi S, Ferraroni M, Gnagnarella P, Parpinel MT, La Vecchia C, et&nbsp;al. Validation of a food-frequency questionnaire to assess dietary intakes in cancer studies in Italy. Results for specific nutrients. Ann Epidemiol. 1996;6:110&ndash;8.","DOI":"10.1016\/1047-2797(95)00129-8"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Franceschi S, Negri E, Salvini S, Decarli A, Ferraroni M, Filiberti R, et&nbsp;al. Reproducibility of an Italian food frequency questionnaire for cancer studies: results for specific food items. Eur J Cancer. 1993;29A:2298&ndash;305.","DOI":"10.1016\/0959-8049(93)90225-5"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Bennett GG, Wolin KY, James SA. Lifecourse socioeconomic position and weight change among blacks: The Pitt County study. Obesity (Silver Spring). 2007;15:172&ndash;81.","DOI":"10.1038\/oby.2007.522"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Myers GJ, Davidson PW, Strain JJ. Nutrient and methyl mercury exposure from consuming fish. J Nutr. 2007;137:2805&ndash;8.","DOI":"10.1093\/jn\/137.12.2805"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Oken E, Radesky JS, Wright RO, Bellinger DC, Amarasiriwardena CJ, Kleinman KP, et&nbsp;al. Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am J Epidemiol. 2008;167:1171&ndash;81.","DOI":"10.1093\/aje\/kwn034"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Haggarty P. Fatty acid supply to the human fetus. Annu Rev Nutr. 2010;30:237&ndash;55.","DOI":"10.1146\/annurev.nutr.012809.104742"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Simmer K, Patole SK, Rao SC. Longchain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev. 2008;(1):CD000376.","DOI":"10.1002\/14651858.CD000376.pub2"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Delgado-Noguera MF, Calvache JA, Bonfill Cosp X. Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. Cochrane Database Syst Rev. 2010;(12):CD007901.","DOI":"10.1002\/14651858.CD007901.pub2"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Auestad N, Scott DT, Janowsky JS, Jacobsen C, Carroll RE, Montalto MB, et&nbsp;al. Visual, cognitive, and language assessments at 39 months: a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age. Pediatrics. 2003;112:e177&ndash;83.","DOI":"10.1542\/peds.112.3.e177"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Reilly S, Wake M, Ukoumunne OC, Bavin E, Prior M, Cini E, et&nbsp;al. Predicting language outcomes at 4 years of age: findings from Early Language in Victoria Study. Pediatrics. 2010;126:e1530&ndash;7.","DOI":"10.1542\/peds.2010-0254"},{"key":"36","unstructured":"36. Capotorti L, Luchino F, Siglienti L, Battaini A, Di Tullio F, Rosenholtz E, et&nbsp;al. La valutazione dell&rsquo;ambiente familiare negli studi longitudinali di sviluppo infantile. Medico e Bambino. 1987;9:16&ndash;23."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Frankenburg WK, Coons CE. Home Screening Questionnaire: its validity in assessing home environment. J Pediatr. 1986;108:624&ndash;6.","DOI":"10.1016\/S0022-3476(86)80853-8"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.06.040"}],"container-title":["Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jea\/23\/5\/23_JE20120168\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T19:30:32Z","timestamp":1563651032000},"score":1,"resource":{"primary":{"URL":"http:\/\/jlc.jst.go.jp\/DN\/JST.JSTAGE\/jea\/JE20120168?lang=en&from=CrossRef&type=abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2188\/jea.je20120168","relation":{},"ISSN":["0917-5040","1349-9092"],"issn-type":[{"value":"0917-5040","type":"print"},{"value":"1349-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}