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World Health Organization World Health Organization Statistical Information System. WHO Mortality Database. 2012."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Malvezzi M, Bertuccio P, Levi F, La Vecchia C, Negri E. European cancer mortality predictions for the year 2013. Ann Oncol. 2013;24(3):792–800.","DOI":"10.1093\/annonc\/mdt010"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.","DOI":"10.1002\/ijc.25516"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Bosetti C, Bertuccio P, Negri E, La Vecchia C, Zeegers MP, Boffetta P. Pancreatic cancer: overview of descriptive epidemiology. Mol Carcinog. 2012;51(1):3–13.","DOI":"10.1002\/mc.20785"},{"key":"5","unstructured":"5. National Office for Cancer Prevention and Control, National Center for Cancer Registry, Disease Prevention and Control Bureau, MOH. Chinese Cancer Registry Annual Report (2012). Beijing: Military Medical Science Press; 2012:12."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. N Engl J Med. 2014 Sep 11;371(11):1039–49.","DOI":"10.1056\/NEJMra1404198"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Pezzilli R, Pagano N. Is diabetes mellitus a risk factor for pancreatic cancer? World J Gastroenterol. 2013;19(30):4861–6.","DOI":"10.3748\/wjg.v19.i30.4861"},{"key":"8","unstructured":"8. Nishino H, Yamada N, Nakata B, Hirakawa K. [Risk factor for pancreatic cancer—alcoholic abuse]. Nihon Rinsho. 2006;64 Suppl 1:14–7."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zyromski NJ, White PB. Pancreatic cancer in obesity: epidemiology, clinical observations, and basic mechanisms. Anticancer Agents Med Chem. 2011;11(5):470–8.","DOI":"10.2174\/187152011795677445"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Tang H, Dong X, Hassan M, Abbruzzese JL, Li D. Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2011;20(5):779–92.","DOI":"10.1158\/1055-9965.EPI-10-0845"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Dítě P, Hermanová M, Trna J, Novotný I, Růžicka M, Liberda M, et al. The role of chronic inflammation: chronic pancreatitis as a risk factor of pancreatic cancer. Dig Dis. 2012;30(3):277–83.","DOI":"10.1159\/000336991"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Heinen MM, Verhage BA, Goldbohm RA, Lumey LH, van den Brandt PA. Physical activity, energy restriction, and the risk of pancreatic cancer: a prospective study in the Netherlands. Am J Clin Nutr. 2011;94(5):1314–23.","DOI":"10.3945\/ajcn.110.007542"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Zhang J, Dhakal IB, Gross MD, Lang NP, Kadlubar FF, Harnack LJ, et al. Physical activity, diet, and pancreatic cancer: a population-based, case-control study in Minnesota. Nutr Cancer. 2009;61(4):457–65.","DOI":"10.1080\/01635580902718941"},{"key":"14","unstructured":"14. Vrieling A, Bueno-de-Mesquita HB, Boshuizen HC, Michaud DS, Severinsen MT, Overvad K, et al. Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2010;126:2394–403."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Parkin DM. 1. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer. 2011;105 Suppl 2:S2–5.","DOI":"10.1038\/bjc.2011.474"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Anderson MA, Zolotarevsky E, Cooper KL, Sherman S, Shats O, Whitcomb DC, et al. Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a multicenter study. Am J Gastroenterol. 2012;107(11):1730–9.","DOI":"10.1038\/ajg.2012.288"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Iodice S, Gandini S, Maisonneuve P, Lowenfels AB. Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg. 2008;393(4):535–45.","DOI":"10.1007\/s00423-007-0266-2"},{"key":"18","unstructured":"18. Lynch SM, Vrieling A, Lubin JH, Kraft P, Mendelsohn JB, Hartge P, et al. Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. Am J Epidemiol. 2009;170:403–13."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Sugimura T. Nutrition and dietary carcinogens. 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Am J Med Sci. 1967 Sep;254(3):322–9.","DOI":"10.1097\/00000441-196709000-00007"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Ghadirian P, Boyle P, Simard A, Baillargeon J, Maisonneuve P, Perret C. Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada. Int J Pancreatol. 1991 Nov–Dec;10(3–4):183–96.","DOI":"10.1007\/BF02924156"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Silverman DT. Risk factors for pancreatic cancer: a case-control study based on direct interviews. Teratog Carcinog Mutagen. 2001;21(1):7–25.","DOI":"10.1002\/1520-6866(2001)21:1<7::AID-TCM3>3.0.CO;2-A"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Hemminki K, Li X. Familial and second primary pancreatic cancers: a nationwide epidemiologic study from Sweden. Int J Cancer. 2003 Feb 10;103(4):525–30.","DOI":"10.1002\/ijc.10863"},{"key":"33","unstructured":"33. Coughlin SS, Calle EE, Patel AV, Thun MJ. Predictors of pancreatic cancer mortality among a large cohort of United States adults. Cancer Causes Control. 2000 Dec;11(10):915–23."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Urayama S, Zou W, Brooks K, Tolstikov V. Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer. Rapid Commun Mass Spectrom. 2010;24(5):613–20.","DOI":"10.1002\/rcm.4420"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Wang F, Herrington M, Larsson J, Permert J. The relationship between diabetes and pancreatic cancer. Mol Cancer. 2003;2:4–8.","DOI":"10.1186\/1476-4598-2-4"},{"key":"36","unstructured":"36. Hsu C, Saif MW. Diabetes and pancreatic cancer. Highlights from the “2011 ASCO Annual Meeting”. Chicago, IL, USA; June 3–7, 2011. JOP. 2011;12:330–3."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Kong X, Li L, Li Z, Xie K. Targeted disruption of orchestration between stroma and tumor cells in pancreatic cancer: molecular basis and therapeutic implications. Cytokine Growth Factor Rev. 2012 December;23(6):343–56.","DOI":"10.1016\/j.cytogfr.2012.06.006"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Jee SH, Ohrr H, Sull JW, Yun JE, Ji M, Samet JM. Fasting serum glucose level and cancer risk in Korean men and women. JAMA. 2005;293(2):194–202.","DOI":"10.1001\/jama.293.2.194"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Yacoub A, Siegel E, Makhoul E. Pancreatic cancer and diabetes mellitus: a retrospective cohort study. J Clin Oncol. 2011;29 Suppl:4102.","DOI":"10.1200\/jco.2011.29.15_suppl.4102"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Cui Y, Andersen DK. Diabetes and pancreatic cancer. Endocr Relat Cancer. 2012 Sep 5;19(5):F9–26.","DOI":"10.1530\/ERC-12-0105"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Sadeghi N, Abbruzzese JL, Yeung SJ, Hassan M, Li D. Effect of metformin on survival of diabetic patients with pancreatic adenocarcinoma. J Clin Oncol. 2011;29 Suppl:4063.","DOI":"10.1200\/jco.2011.29.15_suppl.4063"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Berrington de Gonzalez A, Sweetland S, Spencer E. A meta-analysis of obesity and the risk of pancreatic cancer. Br J Cancer. 2003;89(3):519–23.","DOI":"10.1038\/sj.bjc.6601140"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Luo J, Iwasaki M, Inoue M, Sasazuki S, Otani T, Ye W, et al; JPHC Study Group. Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan—the JPHC study. Cancer Causes Control. 2007;18(6):603–12.","DOI":"10.1007\/s10552-007-9002-z"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. 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