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Genomic epidemiology of SARS-CoV-2 with subsampling focused globally since pandemic start [homepage on the Internet]; c2022. Available from: https:\/\/www.gisaid.org\/phylodynamics\/global\/nextstrain\/."},{"key":"2","unstructured":"2. Tracking SARS-CoV-2 variants [homepage on the Internet]; c2022. Available from: https:\/\/www.who.int\/activities\/tracking-SARS-CoV-2-variants."},{"key":"3","unstructured":"3. COVID-19 rapid guideline: managing the long-term effects of COVID-19 [homepage on the Internet]; c2021. Available from: https:\/\/www.nice.org.uk\/guidance\/ng188."},{"key":"4","unstructured":"4. Coronavirus disease (COVID-19): Post COVID-19 condition [homepage on the Internet]; c2021. Available from: https:\/\/www.who.int\/news-room\/questions-and-answers\/item\/coronavirus-disease-(covid-19)-post-covid-19-condition."},{"key":"5","unstructured":"5. Long COVID or Post-COVID Conditions [homepage on the Internet]; c2022. Available from: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/long-term-effects\/index.html."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. PHOSP-COVID Collaborative Group. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. <i>Lancet Respir Med<\/i>. 2022;10:761\u2013775.","DOI":"10.1016\/S2213-2600(22)00127-8"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Han Q, Zheng B, Daines L, Sheikh A. Long-term sequelae of COVID-19: a systematic review and meta-analysis of one-year follow-up studies on post-COVID symptoms. <i>Pathogens<\/i>. 2022;11:269.","DOI":"10.3390\/pathogens11020269"},{"key":"8","unstructured":"8. Clinical Management of Patients with COVID-19: Management of post COVID-19 conditon (version 2.0) [in Japanese] [homepage on the Internet]; c2022. Available from: https:\/\/www.mhlw.go.jp\/content\/000952747.pdf."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Crook H, Raza S, Nowell J, Young M, Edison P. Long covid-mechanisms, risk factors, and management. <i>BMJ<\/i>. 2021;374:n1648.","DOI":"10.1136\/bmj.n1648"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Nalbandian A, Sehgal K, Gupta A, et\u00a0al. Post-acute COVID-19 syndrome. <i>Nat Med<\/i>. 2021;27:601\u2013615.","DOI":"10.1038\/s41591-021-01283-z"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Tanaka H, Ogata T, Shibata T, et\u00a0al. Shorter incubation period among COVID-19 cases with the BA.1 Omicron variant. <i>Int J Environ Res Public Health<\/i>. 2022;19:6330.","DOI":"10.3390\/ijerph19106330"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Del \u00c1guila-Mej\u00eda J, Wallmann R, Calvo-Montes J, Rodr\u00edguez-Lozano J, Valle-Madrazo T, Aginagalde-Llorente A. Secondary attack rate, transmission and incubation periods, and serial interval of SARS-CoV-2 Omicron variant, Spain. <i>Emerg Infect Dis<\/i>. 2022;28:1224\u20131228.","DOI":"10.3201\/eid2806.220158"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Menni C, Valdes AM, Polidori L, et\u00a0al. Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study. <i>Lancet<\/i>. 2022;399:1618\u20131624.","DOI":"10.1016\/S0140-6736(22)00327-0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ishii S, Sugiyama A, Ito N, et\u00a0al. The role of discrimination in the relation between COVID-19 sequelae, psychological distress, and work impairment in COVID-19 survivors. <i>Sci Rep<\/i>. 2022;12:22218.","DOI":"10.1038\/s41598-022-26332-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Sugiyama A, Miwata K, Kitahara Y, et\u00a0al. Long COVID occurrence in COVID-19 survivors. <i>Sci Rep<\/i>. 2022;12:6039.","DOI":"10.1038\/s41598-022-10051-z"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Fushimi M, Saito S, Shimizu T, Kudo Y, Seki M, Murata K. Prevalence of psychological distress, as measured by the Kessler 6 (K6), and related factors in Japanese employees. <i>Community Ment Health J<\/i>. 2012;48:328\u2013335.","DOI":"10.1007\/s10597-011-9416-7"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Fujino Y, Uehara M, Izumi H, et\u00a0al. Development and validity of a work functioning impairment scale based on the Rasch model among Japanese workers. <i>J Occup Health<\/i>. 2015;57:521\u2013531.","DOI":"10.1539\/joh.15-0135-OA"},{"key":"18","unstructured":"18. COVID-19 Treatment Guidelines [homepage on the Internet]; c2022. Available from: https:\/\/files.covid19treatmentguidelines.nih.gov\/guidelines\/covid19treatmentguidelines.pdf."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ko K, Takahashi K, Nagashima S, et\u00a0al. Exercising the Sanger sequencing strategy for variants screening and full-length genome of SARS-CoV-2 virus during Alpha, Delta, and Omicron outbreaks in Hiroshima. <i>Viruses<\/i>. 2022;14:720.","DOI":"10.3390\/v14040720"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Subramanian A, Nirantharakumar K, Hughes S, et\u00a0al. Symptoms and risk factors for long COVID in non-hospitalized adults. <i>Nat Med<\/i>. 2022;28:1706\u20131714.","DOI":"10.1038\/s41591-022-01909-w"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Tsampasian V, Elghazaly H, Chattopadhyay R, et\u00a0al. 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Available from: https:\/\/www.mhlw.go.jp\/content\/10900000\/001024113.pdf."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Alacevich C, Thalmann I, Nicodemo C, de Lusignan S, Petrou S. Depression and anxiety during and after episodes of COVID-19 in the community. <i>Sci Rep<\/i>. 2023;13:8257.","DOI":"10.1038\/s41598-023-33642-w"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Antonelli M, Pujol JC, Spector TD, Ourselin S, Steves CJ. Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2. <i>Lancet<\/i>. 2022;399:2263\u20132264.","DOI":"10.1016\/S0140-6736(22)00941-2"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Morioka S, Tsuzuki S, Suzuki M, et\u00a0al. Post COVID-19 condition of the Omicron variant of SARS-CoV-2. <i>J Infect Chemother<\/i>. 2022;28:1546\u20131551.","DOI":"10.1016\/j.jiac.2022.08.007"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Nakano Y, Otsuka Y, Honda H, et\u00a0al. Transitional changes in fatigue-related symptoms due to long COVID: a single-center retrospective observational study in Japan. <i>Medicina (Kaunas)<\/i>. 2022;58:1393.","DOI":"10.3390\/medicina58101393"},{"key":"30","unstructured":"30. Self-reported long COVID after infection with the Omicron variant in the UK: 6 May 2022 [homepage on the Internet]; c2022. Available from: https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/conditionsanddiseases\/bulletins\/selfreportedlongcovidafterinfectionwiththeomicronvariant\/6may2022#self-reported-long-covid-after-infection-with-the-omicron-variant-in-the-uk-data."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Hintschich CA, Niv MY, Hummel T. The taste of the pandemic-contemporary review on the current state of research on gustation in coronavirus disease 2019 (COVID-19). <i>Int Forum Allergy Rhinol<\/i>. 2022;12:210\u2013216.","DOI":"10.1002\/alr.22902"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Butowt R, Bilinska K, Von Bartheld CS. Chemosensory dysfunction in COVID-19: integration of genetic and epidemiological data points to D614G spike protein variant as a contributing factor. <i>ACS Chem Neurosci<\/i>. 2020;11:3180\u20133184.","DOI":"10.1021\/acschemneuro.0c00596"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Korber B, Fischer WM, Gnanakaran S, et\u00a0al. Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus. <i>Cell<\/i>. 2020;182:812\u2013827.e19.","DOI":"10.1016\/j.cell.2020.06.043"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Butowt R, Bili\u0144ska K, von Bartheld C. 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Persistent dyspnea after COVID-19 is not related to cardiopulmonary impairment; a cross-sectional study of persistently dyspneic COVID-19, non-dyspneic COVID-19 and controls. <i>Front Physiol<\/i>. 2022;13:917886.","DOI":"10.3389\/fphys.2022.917886"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Parshall MB, Schwartzstein RM, Adams L, et\u00a0al; American Thoracic Society Committee on Dyspnea. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. <i>Am J Respir Crit Care Med<\/i>. 2012;185:435\u2013452.","DOI":"10.1164\/rccm.201111-2042ST"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Halpin SJ, McIvor C, Whyatt G, et\u00a0al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation. <i>J Med Virol<\/i>. 2021;93:1013\u20131022.","DOI":"10.1002\/jmv.26368"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. 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