{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:44:34Z","timestamp":1777715074932,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Psychiatry Med"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia. There are some case reports about this side effect of quetiapine, but possible risk factors are seldom discussed and identified. A case of a patient with hepatocellular carcinoma that developed neutropenia after treatment with quetiapine is described here.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report:<\/jats:title>\n                    <jats:p>A 62-year-old Taiwanese widow with bipolar disorder was diagnosed with hepatocellular carcinoma at age 60. She developed leucopenia after being treated with quetiapine. After quetiapine was discontinued, her white blood cell count returned to normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although neutropenia is not a common side effect of quetiapine, physicians should be cautious about its presentation and associated risk factors. Hepatic dysfunction may be one of the possible risk factors, and concomitant fever may be a diagnostic marker for adverse reaction to quetiapine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2190\/pm.47.3.f","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T09:10:01Z","timestamp":1402909801000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Quetiapine-Induced Neutropenia in a Bipolar Patient with Hepatocellular Carcinoma"],"prefix":"10.1177","volume":"47","author":[{"given":"Han-Ching","family":"Tang","sequence":"first","affiliation":[{"name":"Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Hsuan","family":"Chung","sequence":"additional","affiliation":[{"name":"Taipei Medical University and Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"issue":"2","key":"bibr1-PM.47.3.f","first-page":"96","volume":"49","author":"Chandrasekaran PK","year":"2008","journal-title":"Singapore Medical Journal"},{"key":"bibr2-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1041064"},{"key":"bibr3-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900055"},{"key":"bibr4-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.07.003"},{"key":"bibr5-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.2.188"},{"key":"bibr6-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.42.4.368"},{"key":"bibr7-PM.47.3.f","doi-asserted-by":"crossref","unstructured":"Chou YH, Chiu NM, Yang TT, Feng J, Chan CC, Lee HK. An early improvement in depressive symptoms predicts symptomatic remission of schizophrenia treated with quetiapine: A multicenter, 4-week case-control study. International Clinical Psychopharmacology 2013 Jun 28.","DOI":"10.1097\/YIC.0b013e328363aa33"},{"key":"bibr8-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.3371\/CSRP.5.1.4"},{"key":"bibr9-PM.47.3.f","doi-asserted-by":"crossref","unstructured":"Singh G, Kodela S. Morning pseudoneutropenia during risperidone treatment.\n                      BMJ Case Reports\n                      2009;2009. pii: Bcr06.2008.0288. doi: 10.1136\/bcr.06.2008.0288. Epub 2009 Feb 2.","DOI":"10.1136\/bcr.06.2008.0288"},{"key":"bibr10-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.2.397"},{"key":"bibr11-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0918a"},{"key":"bibr12-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073"},{"key":"bibr13-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.1.89"},{"key":"bibr14-PM.47.3.f","first-page":"CD003038","volume":"6","author":"Paul M","year":"2013","journal-title":"Cochrane Database System Review"},{"key":"bibr15-PM.47.3.f","doi-asserted-by":"crossref","unstructured":"Castagnola E, Mikulska M, Barabino P, Lorenzi I, Haupt R, Viscoli C. Current research in empirical therapy for febrile neutropenia in cancer patients: What should be necessary and what is going on. Expert Opinion on Emergency Drugs 2013, Jun 19.","DOI":"10.1517\/14728214.2013.809419"},{"key":"bibr16-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200969030-00010"},{"key":"bibr17-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200326100-00003"},{"key":"bibr18-PM.47.3.f","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.07.003"}],"container-title":["The International Journal of Psychiatry in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2190\/PM.47.3.f","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2190\/PM.47.3.f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:13:53Z","timestamp":1777457633000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2190\/PM.47.3.f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.2190\/PM.47.3.f"],"URL":"https:\/\/doi.org\/10.2190\/pm.47.3.f","relation":{},"ISSN":["0091-2174","1541-3527"],"issn-type":[{"value":"0091-2174","type":"print"},{"value":"1541-3527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}