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Based on the characteristics of the cytochrome P-450 microsomal enzyme systems, the authors explain the clinical phenomena of induction and inhibition of these enzymes when psychotropic agents interact. This article describes both MFO inducers (barbiturates) and inhibitors (cimeditine, fluoxetine and neuroleptic drugs). With this information, clinicians can enhance the ability to monitor drug interactions of psychotropic agents.<\/jats:p>","DOI":"10.2190\/u0bd-pvhw-ba01-a1d0","type":"journal-article","created":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T21:34:00Z","timestamp":1115156040000},"page":"47-56","source":"Crossref","is-referenced-by-count":10,"title":["Cytochrome P-450 Monooxygenases and Interactions of Psychotropic Drugs"],"prefix":"10.1177","volume":"21","author":[{"given":"Winston W.","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Human Behavior St. Louis University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keh-Ming","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harbor-UCLA Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,3,1]]},"reference":[{"key":"bibr1-U0BD-PVHW-BA01-A1D0","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(18)30755-X"},{"key":"bibr2-U0BD-PVHW-BA01-A1D0","first-page":"1112","volume":"96","author":"Warnes H.","year":"1967","journal-title":"Canadian Medical Association Journal"},{"key":"bibr3-U0BD-PVHW-BA01-A1D0","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.143.5.650"},{"key":"bibr4-U0BD-PVHW-BA01-A1D0","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(78)70909-6"},{"key":"bibr5-U0BD-PVHW-BA01-A1D0","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(18)30526-4"},{"key":"bibr6-U0BD-PVHW-BA01-A1D0","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(18)30527-6"},{"key":"bibr7-U0BD-PVHW-BA01-A1D0","volume-title":"Drug Interactions in Psychiatry","author":"Ciraulo D. 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