{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:06:41Z","timestamp":1793315201414,"version":"4.5.0"},"reference-count":70,"publisher":"LIDSEN Publishing Inc","issue":"04","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OBM Genet"],"published-print":{"date-parts":[[2018,10,25]]},"abstract":"<jats:p>Background: Over the past decade, there has been rising interest in the interaction of &lt;i&gt;Pneumocystis&lt;\/i&gt; with the environment. This interest has arisen in part from the demonstration that environmental factors have important effects on the viability and transmission of microbes, including &lt;i&gt;Pneumocystis&lt;\/i&gt;. Environmental factors include climatological factors such as temperature, humidity, and precipitation, and air pollution factors including carbon monoxide, nitrogen dioxide, sulfur dioxide, and particulate matter. Methods: We undertook a systematic review in order to identify environmental factors associated with &lt;i&gt;Pneumocystis&lt;\/i&gt; infection or PCP, and their effects on human and animal hosts. Results: The systematic review found evidence of associations between &lt;i&gt;Pneumocystis &lt;\/i&gt;infection in animal and human hosts, and climatological and air pollution factors. Data from human studies infers that rather than a seasonal association, presentation with PCP appears to be highest when the average temperature is between 10 and 20&amp;deg;C. There was evidence of an association with hospitalization with PCP and ambient air pollution factors, as well as evidence of an effect of air pollution on both systemic and bronchoscopic lavage fluid humoral responses to &lt;i&gt;Pneumocystis&lt;\/i&gt;. Interpretation of human studies was confounded by possible genetically-determined predisposition to, or protection from infection. Conclusions: This systematic review provides evidence of associations between &lt;i&gt;Pneumocystis &lt;\/i&gt;infection in both animal and human hosts, and climatological and environmental air pollution factors. This information may lead to an improved understanding of the conditions involved in transmission of &lt;i&gt;Pneumocystis&lt;\/i&gt; in both animal and human hosts. Such knowledge is critical to efforts aimed at prevention.<\/jats:p>","DOI":"10.21926\/obm.genet.1804045","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T04:20:55Z","timestamp":1540873255000},"page":"1-20","update-policy":"https:\/\/doi.org\/10.21926\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Relationship between &lt;em&gt;Pneumocystis&lt;\/em&gt; Infection in Animal and Human Hosts, and Climatological and Environmental Air Pollution Factors: A Systematic Review"],"prefix":"10.21926","volume":"02","author":[{"given":"Robert F.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Walzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9387","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"ref=1","unstructured":"Miller RF, Smulian AG, Walzer PD. 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