{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:21:09Z","timestamp":1790335269784,"version":"4.1.0"},"reference-count":43,"publisher":"LIDSEN Publishing Inc","issue":"03","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OBM Transplant"],"accepted":{"date-parts":[[2020,7,2]]},"published-print":{"date-parts":[[2020,7,7]]},"abstract":"<jats:p>Pancreatic islet transplantation is a rapidly evolving field. It has been increasingly regarded as a promising approach for the correction of dysglycemia associated with type 1 diabetes mellitus (allogenic islet transplantation), or the prevention of surgical diabetes in chronic pancreatitis subjects undergoing total pancreatectomy (autologous islet transplantation). In this review, we discuss the latest literature pertaining to metabolic outcomes of autologous and allogenic islet transplantation, shedding close light on our own latest experience in the autologous islet transplantation setting.<\/jats:p>","DOI":"10.21926\/obm.transplant.2003115","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T02:24:57Z","timestamp":1594088697000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.21926\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pancreatic Islet Cell Transplantation: Graft Stability and Metabolic Outcomes"],"prefix":"10.21926","volume":"04","author":[{"given":"Khawla F.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Hatipoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9387","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"ref=1","doi-asserted-by":"crossref","unstructured":"Robertson RP. Islet transplantation as a treatment for diabetes - a work in progress. N Engl J Med. 2004; 350: 694-705.","DOI":"10.1056\/NEJMra032425"},{"key":"ref=2","doi-asserted-by":"crossref","unstructured":"Rother KI, Harlan DM. Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus. J Clin Invest. 2004; 114: 877-883.","DOI":"10.1172\/JCI200423235"},{"key":"ref=3","unstructured":"Ali KF, Hatipoglu B. Islet cell autotransplantation update. CellR4 Repair Replace Regen Reprogram. 2019; 7: e2609."},{"key":"ref=4","doi-asserted-by":"crossref","unstructured":"Johnston PC, Lin YK, Walsh RM, Bottino R, Stevens TK, Trucco M, et al. Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience. J Clin Endocrinol Metab. 2015; 100: 1765-1770.","DOI":"10.1210\/jc.2014-4298"},{"key":"ref=5","doi-asserted-by":"crossref","unstructured":"Thompson DM, Meloche M, Ao Z, Paty B, Keown P, Shapiro RJ, et al. Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy. Transplantation. 2011; 91: 373-378.","DOI":"10.1097\/TP.0b013e31820437f3"},{"key":"ref=6","doi-asserted-by":"crossref","unstructured":"Vantyghem MC, Quintin D, Caiazzo R, Leroy C, Raverdy V, Cassim F, et al. Improvement of electrophysiological neuropathy after islet transplantation for type 1 diabetes: A 5-year prospective study. Diabetes Care. 2014; 37: e141-e142.","DOI":"10.2337\/dc14-0320"},{"key":"ref=7","doi-asserted-by":"crossref","unstructured":"Walsh RM, Saavedra JA, Lentz G, Guerron AD, Scheman J, Stevens T, et al. Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis. J Gastrointest Surg. 2012; 16: 1469-1477.","DOI":"10.1007\/s11605-012-1914-6"},{"key":"ref=8","doi-asserted-by":"crossref","unstructured":"Kleeff J, Whitcomb DC, Shimosegawa T, Esposito I, Lerch MM, Gress T, et al. Chronic pancreatitis. Nat Rev Dis Primers. 2017; 3: 17060.","DOI":"10.1038\/nrdp.2017.60"},{"key":"ref=9","doi-asserted-by":"crossref","unstructured":"Kesseli S, Smith K, Gardner T. Total pancreatectomy with islet autologous transplantation: The cure for chronic pancreatitis? Clin Transl Gastroenterol. 2015; 6: e73.","DOI":"10.1038\/ctg.2015.2"},{"key":"ref=10","doi-asserted-by":"crossref","unstructured":"Najarian JS, Sutherland DE, Baumgartner DI, Burke BA, Rynasiewicz JJ, Matas AJ, et al. Total or near total pancreatectomy and islet autotransplantation for treatment of chronic pancreatitis. Ann Surg. 1980; 192: 526.","DOI":"10.1097\/00000658-198010000-00011"},{"key":"ref=11","doi-asserted-by":"crossref","unstructured":"Garcea G, Weaver J, Phillips J, Pollard CA, Ilouz SC, M'Balu AW, et al. Total pancreatectomy with and without islet cell transplantation for chronic pancreatitis. Pancreas. 2009; 38: 1-7.","DOI":"10.1097\/MPA.0b013e3181825c00"},{"key":"ref=12","doi-asserted-by":"crossref","unstructured":"Sutherland DE, Radosevich DM, Bellin MD, Hering BJ, Beilman GJ, Dunn TB, et al. Total pancreatectomy and islet autotransplantation for chronic pancreatitis. J Am Coll Surg. 2012; 214: 409-424.","DOI":"10.1016\/j.jamcollsurg.2011.12.040"},{"key":"ref=13","doi-asserted-by":"crossref","unstructured":"Ali KF, San Martin VT, Walsh RM, Bottino R, Stevens T, Trucco M, et al. Change in functional beta cell capacity with time following autologous islet transplantation. Pancreas. 2019; 48: 656\u2010661.","DOI":"10.1097\/MPA.0000000000001315"},{"key":"ref=14","doi-asserted-by":"crossref","unstructured":"Ryan EA, Paty BW, Senior PA, Lakey JR, Bigam D, Shapiro AJ. \u03b2-Score: An assessment of \u03b2-cell function after islet transplantation. Diabetes Care. 2005; 28: 343-347.","DOI":"10.2337\/diacare.28.2.343"},{"key":"ref=15","doi-asserted-by":"crossref","unstructured":"Forbes S, Oram RA, Smith A, Lam A, Olateju T, Imes S, et al. Validation of the BETA-2 score: An improved tool to estimate beta cell function after clinical islet transplantation using a single fasting blood sample. Am J Transplant. 2016; 16: 2704-2713.","DOI":"10.1111\/ajt.13807"},{"key":"ref=16","doi-asserted-by":"crossref","unstructured":"Naziruddin B, Iwahashi S, Kanak MA, Takita M, Itoh T, Levy MF. Evidence for instant blood-mediated inflammatory reaction in clinical autologous islet transplantation. Am J Transplant. 2014; 14: 428-437.","DOI":"10.1111\/ajt.12558"},{"key":"ref=17","doi-asserted-by":"crossref","unstructured":"Van Der Windt DJ, Marigliano M, He J, Votyakova TV, Echeverri GJ, Ekser B, et al. Early islet damage after direct exposure of pig islets to blood: Has humoral immunity been underestimated? Cell Transplant. 2012; 21: 1791-1802.","DOI":"10.3727\/096368912X653011"},{"key":"ref=18","doi-asserted-by":"crossref","unstructured":"Itoh T, Iwahashi S, Kanak MA, Shimoda M, Takita M, Chujo D, et al. Elevation of high-mobility group box 1 after clinical autologous islet transplantation and its inverse correlation with outcomes. Cell Transplant. 2014; 23: 153-165.","DOI":"10.3727\/096368912X658980"},{"key":"ref=19","unstructured":"Yumiba T, Miyata M, Izukura M, Tanaka Y, Dousei T, Yamaguchi T, et al. Islet rest protects against exhaustion of insulin production in transplanted islets. Transplant Proc. 1992; 24: 995-996."},{"key":"ref=20","doi-asserted-by":"crossref","unstructured":"Merino JF, Nacher V, Raurell M, Biarnes M, Soler J, Montanya E. Optimal insulin treatment in syngeneic islet transplantation. Cell Transplant. 2000; 9: 11-18.","DOI":"10.1177\/096368970000900102"},{"key":"ref=21","doi-asserted-by":"crossref","unstructured":"Fiorina P, Vergani A, Petrelli A, D'Addio F, Monti L, Abdi R, et al. Metabolic and immunological features of the failing islet-transplanted patient. Diabetes Care. 2008; 31: 436-438.","DOI":"10.2337\/dc07-1831"},{"key":"ref=22","doi-asserted-by":"crossref","unstructured":"Klimek AM, Soukhatcheva G, Thompson DM, Warnock GL, Salehi M, Rilo H, et al. Impaired proinsulin processing is a characteristic of transplanted islets. Am J Transplant. 2009; 9: 2119-2125.","DOI":"10.1111\/j.1600-6143.2009.02740.x"},{"key":"ref=23","unstructured":"Ali KF, San Martin VT, Hatipo\u011flu B. Beta cell stress in insulin independent subjects following total pancreatectomy and autologous islet transplantation. Turk Klin Immunol Alerji. 2019; 2019: 39\u201044."},{"key":"ref=24","doi-asserted-by":"crossref","unstructured":"Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Vulnerability of islets in the immediate posttransplantation period: Dynamic changes in structure and function. Diabetes. 1996; 45: 1161-1167.","DOI":"10.2337\/diab.45.9.1161"},{"key":"ref=25","doi-asserted-by":"crossref","unstructured":"Bottino R, Balamurugan AN, Bertera S, Pietropaolo M, Trucco M, Piganelli JD. Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes. 2002; 51: 2561-2567.","DOI":"10.2337\/diabetes.51.8.2561"},{"key":"ref=26","doi-asserted-by":"crossref","unstructured":"Bellin MD, Parazzoli S, Oseid E, Bogachus LD, Schuetz C, Patti ME, et al. Defective glucagon secretion during hypoglycemia after intrahepatic but not nonhepatic islet autotransplantation. Am J Transplant. 2014; 14: 1880-1886.","DOI":"10.1111\/ajt.12776"},{"key":"ref=27","doi-asserted-by":"crossref","unstructured":"Hering BJ, Clarke WR, Bridges ND, Eggerman TL, Alejandro R, Bellin MD, et al. Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia. Diabetes Care. 2016; 39: 1230-1240.","DOI":"10.2337\/dc15-1988"},{"key":"ref=28","doi-asserted-by":"crossref","unstructured":"Sutherland DER, Radosevich DM, Bellin MD, Hering BJ, Beilman GJ, Dunn TB, et al. Total pancreatectomy and islet autotransplantation for chronic pancreatitis. J Am Coll Surg. 2012; 214: 409-424.","DOI":"10.1016\/j.jamcollsurg.2011.12.040"},{"key":"ref=29","doi-asserted-by":"crossref","unstructured":"Christoffersson G, Henriksnas J, Johansson L, Rolny C, Ahlstrom H, Caballero-Corbalan J, et al. Clinical and experimental pancreatic islet transplantation to striated muscle: Establishment of a vascular system similar to that in native islets. Diabetes. 2010; 59: 2569-2578.","DOI":"10.2337\/db10-0205"},{"key":"ref=30","doi-asserted-by":"crossref","unstructured":"Maffi P, Balzano G, Ponzoni M, Nano R, Sordi V, Melzi R, et al. Autologous pancreatic islet transplantation in human bone marrow. Diabetes. 2013; 62: 3523-3531.","DOI":"10.2337\/db13-0465"},{"key":"ref=31","unstructured":"CITR Ninth Annual Report. Rockville: The Emmes Company; 2020. Available from: https:\/\/citregistry.org\/system\/files\/9AR_Report.pdf (Accessed on June 6, 2022)."},{"key":"ref=32","doi-asserted-by":"crossref","unstructured":"Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, et al. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care. 2012; 35: 1436.","DOI":"10.2337\/dc12-0063"},{"key":"ref=33","doi-asserted-by":"crossref","unstructured":"Lablanche S, Vantyghem MC, Kessler L, Wojtusciszyn A, Borot S, Thivolet C, et al. Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): A multicentre, randomised controlled trial. Lancet Diabetes Endocrinol. 2018; 6: 527-537.","DOI":"10.1016\/S2213-8587(18)30078-0"},{"key":"ref=34","doi-asserted-by":"crossref","unstructured":"D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol. 2005; 23: 1534-1541.","DOI":"10.1038\/nbt1163"},{"key":"ref=35","doi-asserted-by":"crossref","unstructured":"Guo T, Hebrok M. Stem cells to pancreatic beta-cells: New sources for diabetes cell therapy. Endocr Rev. 2009; 30: 214-227.","DOI":"10.1210\/er.2009-0004"},{"key":"ref=36","doi-asserted-by":"crossref","unstructured":"Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008; 26: 443-452.","DOI":"10.1038\/nbt1393"},{"key":"ref=37","doi-asserted-by":"crossref","unstructured":"Stainier D. No stem cell is an islet (yet). N Engl J Med. 2006; 354: 521.","DOI":"10.1056\/NEJMcibr055048"},{"key":"ref=38","doi-asserted-by":"crossref","unstructured":"Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, et al. Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology. 2009; 150: 2145-2152.","DOI":"10.1210\/en.2008-1116"},{"key":"ref=39","doi-asserted-by":"crossref","unstructured":"Hering BJ, Wijkstrom M, Graham ML, Harstedt M, Aasheim TC, Jie T, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med. 2006; 12: 301-303.","DOI":"10.1038\/nm1369"},{"key":"ref=40","doi-asserted-by":"crossref","unstructured":"Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, Jiang W, et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med. 2006; 12: 304-306.","DOI":"10.1038\/nm1375"},{"key":"ref=41","doi-asserted-by":"crossref","unstructured":"Van Der Windt DJ, Bottino R, Casu A, Campanile N, Smetanka C, He J, et al. Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant. 2009; 9: 2716-2726.","DOI":"10.1111\/j.1600-6143.2009.02850.x"},{"key":"ref=42","doi-asserted-by":"crossref","unstructured":"Eriksson O, Eich T, Sundin A, Tibell A, Tufveson G, Andersson H, et al. Positron emission tomography in clinical islet transplantation. Am J Transplant. 2009; 9: 2816-2824.","DOI":"10.1111\/j.1600-6143.2009.02844.x"},{"key":"ref=43","doi-asserted-by":"crossref","unstructured":"Rickels MR, Robertson RP. Pancreatic islet transplantation in humans: Recent progress and future directions. Endocr Rev. 2019; 40: 631-668.","DOI":"10.1210\/er.2018-00154"}],"container-title":["OBM Transplantation"],"original-title":[],"link":[{"URL":"https:\/\/www.lidsen.com\/journals\/transplantation\/transplantation-04-03-115\/obm.transplant.2003115.xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.lidsen.com\/journals\/transplantation\/transplantation-04-03-115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T08:18:50Z","timestamp":1761725930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.lidsen.com\/journals\/transplantation\/transplantation-04-03-115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":43,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020]]},"published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.21926\/obm.transplant.2003115","relation":{},"ISSN":["2577-5820"],"issn-type":[{"value":"2577-5820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]}}}