{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:30Z","timestamp":1790776650182,"version":"4.1.0"},"reference-count":27,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Form Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec sec-type=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Breast cancer survivorship requires attention to treatment-related changes in body composition, nutritional status, and quality of life. Bioelectrical impedance phase angle is influenced by tissue electrical properties and fluid distribution and may provide complementary whole-body and segmental information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"objective\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study described perioperative body-composition and phase-angle measures in women undergoing breast cancer surgery after neoadjuvant chemotherapy or treated through a surgery-first pathway. It also estimated T0-to-T2 changes and documented the availability of selected longitudinal variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      BC-NUTRITION (Body Composition and Nutrition Trajectories in Breast Cancer) is a prospective 2-cohort observational study with 5 planned assessments from admission to 6 months after discharge. The present exploratory pilot analysis included 30 women in cohort A, assessed after neoadjuvant chemotherapy, and 65 women in cohort B, who were treated through a surgery-first pathway. T1 measurements were displayed descriptively; inferential analyses used T0 values and participant-level T0-to-T2 changes. T0 between-cohort comparisons used Welch 2-sample\n                      <jats:italic>t<\/jats:italic>\n                      tests, within-cohort changes used paired\n                      <jats:italic>t<\/jats:italic>\n                      tests, and between-cohort differences in change used Welch tests. Benjamini-Hochberg\n                      <jats:italic>q<\/jats:italic>\n                      values were calculated across the 13 between-cohort change comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All 95 participants had complete data for the 13 selected longitudinal variables at T0, T1, and T2. At T0, cohort A had lower albumin, absolute lymphocyte count, prognostic nutritional index, and whole-body 50-kHz phase angle. The whole-body phase-angle means were 4.64\u00b0 (SD 0.66) and 5.23\u00b0 (SD 0.62), with a difference of \u22120.59\u00b0 (95% CI \u22120.88\u00b0 to \u22120.31\u00b0;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). Cohort A had a higher whole-body extracellular water to total body water ratio (ECW\/TBW) than cohort B (0.3890 vs 0.3815;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). Ipsilateral upper-limb 50-kHz phase angle changed by \u22120.50\u00b0 in cohort A and \u22120.51\u00b0 in cohort B between T0 and T2. The between-cohort difference was 0.01\u00b0 (95% CI \u22120.17\u00b0 to 0.19\u00b0;\n                      <jats:italic>P<\/jats:italic>\n                      =.93). The corresponding difference in whole-body phase-angle change was 0.14\u00b0 (95% CI \u22120.02\u00b0 to 0.30\u00b0;\n                      <jats:italic>P<\/jats:italic>\n                      =.09). No\n                      <jats:italic>q<\/jats:italic>\n                      value for the 13 between-cohort change comparisons was below 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The treatment pathways differed in selected laboratory and whole-body bioelectrical measures at T0. The mean upper-limb phase angle ipsilateral to the recorded tumor side decreased in both cohorts between T0 and T2. All five prespecified perioperative feasibility thresholds were met in the available T0-to-T2 data. Assessment acceptability and T3\/T4 follow-up were not evaluated. Definitive interpretation requires standardized acquisition, a prechemotherapy baseline, relevant clinical covariates, and outpatient follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/102885","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:50:20Z","timestamp":1787907020000},"page":"e102885-e102885","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Body-Composition and Phase-Angle Measures in Women Undergoing Breast Cancer Surgery After Neoadjuvant Chemotherapy or Treated Through a Surgery-First Pathway (BC-NUTRITION): Exploratory 2-Cohort Pilot 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