{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:58:41Z","timestamp":1782845921881,"version":"3.54.5"},"reference-count":38,"publisher":"JMIR Publications Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"\n Background<\/jats:title>\n Several studies have shown that exposure of the fetus and newborn to prenatal and perinatal events, respectively, may influence the health outcomes of the child throughout their life cycle.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to increase the knowledge on the impact of different intrauterine environments on child growth and development, as we know that pregnancy and early years are a window of opportunity for health promotion and prevention interventions of diseases.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The recruitment occurred 24 to 48 hours after delivery and involved mothers and their newborns in 2 public hospitals in Porto Alegre, Brazil, from December 2011 to January 2016. The mothers-newborns dyads were allocated to 5 groups: diabetes mellitus, mothers with a clinical diagnosis of diabetes; systemic arterial hypertension (SAH), mothers with a clinical diagnosis of systematic arterial hypertensive disease during pregnancy; maternal smoking, mothers who smoked at any moment of gestation; small for gestational age (SGA), mothers with SGA newborns because of intrauterine growth restriction; and control, mothers without the clinical characteristics previously mentioned. Several protocols and anthropometric measurements were applied in the interviews at immediate postpartum and 7 and 15 days and 1, 3, and 6 months after birth. For this study, we analyzed only data collected during postpartum interviews. The statistical analyses were performed using Pearson chi-square test, Mann-Whitney test, or Kruskal-Wallis test with Dunn post hoc. The significance level was set at 5%. The Hospital Ethics and Research Committees approved the study.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 485 eligible mothers-newborns dyads, 400 agreed to participate (82.5%, 400\/485). As expected, newborns from the SGA group had significantly lower birth weight, smaller stature, and lower cephalic perimeter (P<.001). This group also had the highest percentage of primiparous women in comparison with other groups (P=.005) except for control. Mothers from the SAH group had the highest mean age, the highest percentage of cesarean sections, and presented greater gestational weight gain.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this study, we describe the planning and structure for the systematic follow-up of mother-newborn dyads in the first 6 months after birth, considering the important demographic and epidemiological transition scenario in Brazil. The results of this prospective longitudinal study may provide a better understanding of the causal mechanisms involved in health and life course disease related to different adverse intrauterine environments.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/12970","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T21:33:31Z","timestamp":1566423211000},"page":"e12970","source":"Crossref","is-referenced-by-count":16,"title":["Impact of Perinatal Different Intrauterine Environments on Child Growth and Development: Planning and Baseline Data for a Cohort Study"],"prefix":"10.2196","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-868X","authenticated-orcid":false,"given":"Isabel Cristina Ribas","family":"Werlang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-4472","authenticated-orcid":false,"given":"Juliana Rombaldi","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-4014","authenticated-orcid":false,"given":"Marina","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2318-1839","authenticated-orcid":false,"given":"Thiago Beltram","family":"Marcelino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-9640","authenticated-orcid":false,"given":"Vera Lucia","family":"Bosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-0776","authenticated-orcid":false,"given":"Mariana Bohns","family":"Michalowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-3961","authenticated-orcid":false,"given":"Cl\u00e9cio Homrich","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-284X","authenticated-orcid":false,"given":"Marcelo Zubaran","family":"Goldani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2011.01.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000487618"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.6.1235"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01802.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2217\/phe.10.55"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.172387"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174416000209"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.078"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.03.008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2196"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/1753465813479428"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00386-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-12-25"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq130"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/nur.4770120508","volume":"12","author":"Pridham, KF","year":"1989","journal-title":"Res Nurs Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.PEP.0000114843.92102.98"},{"key":"ref18","author":"Coeli, C","year":"2008","journal-title":"Epidemiologia. 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