{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:04:31Z","timestamp":1782846271061,"version":"3.54.5"},"reference-count":45,"publisher":"JMIR Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Food Guide for the Brazilian Population relies on natural or minimally processed foods mainly of plant origin such as beans and rice with low oil, salt, and sugar content and limited consumption of ultraprocessed foods. Reduction of ultraprocessed foods improves diet quality and energy consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study is to evaluate the effectiveness of an intervention for the treatment of obesity in children, with counseling based on the Brazilian Food Guide plus control of total energy intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A parallel, randomized clinical trial will include children aged 7 to 12 years. Randomization will be performed in blocks of 10 individuals using computer-generated random sequence numbers. Both the control and intervention groups will participate in 6 standardized educational activities based on the 10 steps of the Brazilian Food Guide. These activities will be conducted at the University Hospital Toy Library, located in the pediatric outpatient clinic. For the intervention group, in addition to the educational activities, an individualized food plan based on the nutritional recommendations of the Brazilian Society of Pediatrics will be prescribed and discussed with the mothers and fathers. The primary outcome of the study will be variations in body mass index, and secondary outcomes will include analysis of insulin resistance, blood pressure, body fat percentage, and waist and neck circumference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This project was funded by the National Council for Scientific and Technological Development in December 2017 (grant no 408333\/2017-0). Recruitment began in August 2018 and by September 2019, we had enrolled the 101 participants. In addition to the patients referred by the national system of regulation, recruitment was made by medical outpatient referral and external indication. This is an ongoing study. We expect the results to be published in November 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At the end of the project, in case of a positive result, a protocol for the treatment of obesity based on the Brazilian Food Guide will be proposed to the Unified Health System. A successful method to reduce childhood obesity is expected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Brazilian Registry of Clinical Trials RBR-3st5sn; http:\/\/www.ensaiosclinicos.gov.br\/rg\/RBR-3st5sn<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>International Registered Report Identifier (IRRID)<\/jats:title>\n                    <jats:p>DERR1-10.2196\/16170<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/16170","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T15:54:24Z","timestamp":1588607664000},"page":"e16170","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Childhood Obesity Based on Brazilian Dietary Guidelines Plus Energy Restriction (PAPPAS HUPE Study): Protocol for a Randomized Clinical Trial"],"prefix":"10.2196","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8691-6818","authenticated-orcid":false,"given":"Joana Maia","family":"Brandao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-5354","authenticated-orcid":false,"given":"Rosely","family":"Sichieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3947-9800","authenticated-orcid":false,"given":"Simone Augusta","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1101-8746","authenticated-orcid":false,"given":"Eliseu","family":"Verly-Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9886-9796","authenticated-orcid":false,"given":"Rosangela Alves","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-4400","authenticated-orcid":false,"given":"In\u00eas Rugani Ribeiro De","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5484-4880","authenticated-orcid":false,"given":"Bruna Kulik","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-5868","authenticated-orcid":false,"given":"Alessandra Silva Dias De","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8633-7290","authenticated-orcid":false,"given":"Emanuele Souza","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-5628","authenticated-orcid":false,"given":"Diana Barbosa","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61746-3"},{"key":"ref2","unstructured":"World Health OrganizationCommission on Ending Childhood Obesity: facts and figures on childhood obesity20142019-11-20http:\/\/apps.who.int\/iris\/bitstream\/10665\/204176\/1\/9789241510066_eng.pdf?ua=1"},{"key":"ref3","unstructured":"Instituto Brasileiro De Geografia E Estat\u00edsticaPesquisa de Or\u00e7amentos Familiares 2008-2009: antropometria e estado nutricional de crian\u00e7as, adolescentes e adultos no Brasil20092019-11-20Rio de JaneiroInstituto Brasileiro De Geografia E Estat\u00edsticahttp:\/\/biblioteca.ibge.gov.br\/index.php\/biblioteca-catalogo?view=detalhes&id=245419"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1590\/S01518-8787.2016050006698"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1590\/0102-311X00016814"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102013000700007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713231"},{"key":"ref8","unstructured":"World Health OrganizationGlobal action plan for the prevention and control of noncommunicable disease 2013-20202019-11-20https:\/\/www.who.int\/nmh\/events\/ncd_action_plan\/en\/"},{"key":"ref9","year":"2014","journal-title":"Guia Alimentar Para a Popula\u00e7\u00e3o Brasileira, 2nd Edition"},{"issue":"1-3","key":"ref10","first-page":"28","volume":"7","author":"Monteiro, CA","year":"2016","journal-title":"World Nutrition"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980017000234"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980011001571"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092752"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1590\/s0034-8910.2015049005572"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980012005009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.08.001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.29"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2008001400002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-015-0160-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194555"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.C869"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1176"},{"key":"ref24","year":"2018","journal-title":"Caderno de Atividades: Promo\u00e7\u00e3o da Alimenta\u00e7\u00e3o Adequada e Saud\u00e1vel Educa\u00e7\u00e3o Infantil"},{"key":"ref25","year":"2001","journal-title":"DRI Dietary Reference Intakes: Applications in Dietary Assessment"},{"key":"ref26","year":"2012","journal-title":"Manual de Orienta\u00e7\u00e3o para a alimenta\u00e7\u00e3o do lactente, do pr\u00e9 escolar, do escolar, do adolescente e na escola, n. 3\u00b0 edi\u00e7\u00e3o"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"g1687","DOI":"10.1136\/bmj.g1687","volume":"348","author":"Hoffmann, TC","year":"2014","journal-title":"BMJ"},{"key":"ref28","first-page":"3","author":"Gordon, C","year":"1988","journal-title":"Anthropometric Standardization Reference Manual. 1st Edition"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.2.814"},{"key":"ref30","author":"Callaway, CW","year":"1991","journal-title":"Anthropometric Standardization Reference Manual"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.2471\/blt.07.043497"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2009000100003"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"Friedewald, WT","year":"1972","journal-title":"Clin Chem"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20170121"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-S005"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5497201600020020"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1590\/0102-311X00151913"},{"key":"ref41","unstructured":"Associa\u00e7\u00e3o Brasileira de Empresas de PesquisaAssocia\u00e7\u00e3o Brasileira de Empresas de Pesquisa20162018-07-23Crit\u00e9rio Brasil: crit\u00e9rio de classifica\u00e7\u00e3o econ\u00f4mica Brasil 2015http:\/\/www.abep.org\/criterio-brasil"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.095471"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000217362.34748.e0"},{"key":"ref44","doi-asserted-by":"crossref","DOI":"10.1201\/9781420035285","author":"Hardin, J","year":"2002","journal-title":"Generalized Estimating Equations"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2196\/12792"}],"container-title":["JMIR Research Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.researchprotocols.org\/2020\/6\/e16170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:09:54Z","timestamp":1782842994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchprotocols.org\/2020\/6\/e16170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2196\/16170","relation":{"has-preprint":[{"id-type":"doi","id":"10.2196\/preprints.16170","asserted-by":"object"}]},"ISSN":["1929-0748"],"issn-type":[{"value":"1929-0748","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]}}}