{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:51:24Z","timestamp":1782841884014,"version":"3.54.5"},"reference-count":70,"publisher":"JMIR Publications Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Diabetes"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes mellitus, which causes dysregulation of blood glucose in humans, is a major public health challenge. Patients with diabetes must monitor their glycemic levels to keep them in a healthy range. This task is made easier by using continuous glucose monitoring (CGM) devices and relaying their output to smartphone apps, thus providing users with real-time information on their glycemic fluctuations and possibly predicting future trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to discuss various challenges of predictive monitoring of glycemia and examines the accuracy and blood glucose control effects of Diabits, a smartphone app that helps patients with diabetes monitor and manage their blood glucose levels in real time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from CGM devices and user input, Diabits applies machine learning techniques to create personalized patient models and predict blood glucose fluctuations up to 60 min in advance. These predictions give patients an opportunity to take pre-emptive action to maintain their blood glucose values within the reference range. In this retrospective observational cohort study, the predictive accuracy of Diabits and the correlation between daily use of the app and blood glucose control metrics were examined based on real app users\u2019 data. Moreover, the accuracy of predictions on the 2018 Ohio T1DM (type 1 diabetes mellitus) data set was calculated and compared against other published results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On the basis of more than 6.8 million data points, 30-min Diabits predictions evaluated using Parkes Error Grid were found to be 86.89% (5,963,930\/6,864,130) clinically accurate (zone A) and 99.56% (6,833,625\/6,864,130) clinically acceptable (zones A and B), whereas 60-min predictions were 70.56% (4,843,605\/6,864,130) clinically accurate and 97.49% (6,692,165\/6,864,130) clinically acceptable. By analyzing daily use statistics and CGM data for the 280 most long-standing users of Diabits, it was established that under free-living conditions, many common blood glucose control metrics improved with increased frequency of app use. For instance, the average blood glucose for the days these users did not interact with the app was 154.0 (SD 47.2) mg\/dL, with 67.52% of the time spent in the healthy 70 to 180 mg\/dL range. For days with 10 or more Diabits sessions, the average blood glucose decreased to 141.6 (SD 42.0) mg\/dL (P&lt;.001), whereas the time in euglycemic range increased to 74.28% (P&lt;.001). On the Ohio T1DM data set of 6 patients with type 1 diabetes, 30-min predictions of the base Diabits model had an average root mean square error of 18.68 (SD 2.19) mg\/dL, which is an improvement over the published state-of-the-art results for this data set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diabits accurately predicts future glycemic fluctuations, potentially making it easier for patients with diabetes to maintain their blood glucose in the reference range. Furthermore, an improvement in glucose control was observed on days with more frequent Diabits use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/18660","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T13:48:26Z","timestamp":1596116906000},"page":"e18660","source":"Crossref","is-referenced-by-count":21,"title":["The Diabits App for Smartphone-Assisted Predictive Monitoring of Glycemia in Patients With Diabetes: Retrospective Observational Study"],"prefix":"10.2196","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-3681","authenticated-orcid":false,"given":"Stan","family":"Kriventsov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-7533","authenticated-orcid":false,"given":"Alexander","family":"Lindsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-9813","authenticated-orcid":false,"given":"Amir","family":"Hayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"ref1","year":"2016","journal-title":"Global Report on Diabetes"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.18.2.258"},{"key":"ref3","author":"Leahy, J","year":"2000","journal-title":"Medical Management of Diabetes Mellitus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1245"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2015.0417"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0654"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcontrol.2012.09.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1172\/jci110398"},{"key":"ref9","unstructured":"SorensenJA Physiologic Model of Glucose Metabolism in Man and Its Use to Design and Assess Improved Insulin Therapies for DiabetesCarnegie Mellon School of Computer Science2020-06-12http:\/\/www.cs.cmu.edu\/~.\/dmilam\/files\/sorensen_thesis.pdf"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/B978-012160245-1\/50013-1","author":"Caumo, A","year":"2001","journal-title":"Modelling Methodology for Physiology and Medicine"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnum.2005.04.023"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2007.893506"},{"key":"ref13","first-page":"277","author":"Georga, E","year":"2011","journal-title":"Knowledge-Oriented Applications in Data Mining"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.889774"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/193229680700100405"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2008.0065"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/iembs.2011.6091959"},{"key":"ref18","unstructured":"XieJWangQBenchmark machine learning approaches with classical time series approaches on the blood glucose level prediction challenge2018Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden97102"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.23919\/acc.2004.1383731"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2010.09.012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814524080"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprocont.2018.02.003"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/1932296819880864"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1109\/iembs.2006.260640"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200507"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2009.0076"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2012.2188893"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fams.2017.00014"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1109\/embc.2017.8037460"},{"key":"ref30","unstructured":"MartinssonJSchliepAEliassonBAutomatic Blood Glucose Prediction With Confidence Using Recurrent Neural Networks2018Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden6468"},{"key":"ref31","unstructured":"ChenJLiKHerreroPDilated recurrent neural network for short-time prediction of glucose concentration2018Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden6973"},{"key":"ref32","unstructured":"ZhuTLiKHerreroPA deep learning algorithm for personalized blood glucose prediction2018Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden7478"},{"key":"ref33","unstructured":"BertachiABiagiLContrerasIPrediction of Blood Glucose Levels and Nocturnal Hypoglycemia Using Physiological Models and Artificial Neural Networks2018Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden8590"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2019.2908488"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s41666-019-00059-y"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2019.103255"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1109\/TITB.2012.2219876"},{"key":"ref38","unstructured":"PlisKBunescuRMarlingCA machine learning approach to predicting blood glucose levels for diabetes management2014AAAI Workshop: Modern Artificial Intelligence for Health Analytics2014Quebec City, Canada3539"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2012.6346567"},{"key":"ref40","unstructured":"MidroniCLeimbiglerPBaruahGPredicting glycemia in type 1 diabetes patients: experiments with XGBoost2020Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden7984"},{"key":"ref41","unstructured":"ContrerasIBertachiABiagiLUsing grammatical evolution to generate short-term blood glucose prediction models2020Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden9196"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1177\/1932296816662047"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2010.0151"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1922"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0079"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.2174\/157339908785294389"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2011.0033"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.10.5.622"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.8.1143"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700517"},{"key":"ref51","unstructured":"MarlingCBunescuRThe OhioT1DM Dataset for Blood Glucose Level Prediction2018Proc 3rd Int Workshop on Knowl Discov in Healthcare Data2018Stockholm, Sweden"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300528"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400507"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814554797"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0112"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12506"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.2337\/db18-738-p"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.2337\/db19-922-p"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1114\/1.1535411"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1177\/1932296813514502"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.5555\/3009657.3009730"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.5555\/2998981.2999003"},{"key":"ref63","unstructured":"LeachPMeallingMSalzRA Universally Unique IDentifier (UUID) URN NamespaceInternet Engineering Task Forcehttps:\/\/tools.ietf.org\/html\/rfc4122"},{"key":"ref64","unstructured":"45 CFR 46The US Department of Health and Human Services (HHS)2020-06-15https:\/\/www.hhs.gov\/ohrp\/regulations-and-policy\/regulations\/45-cfr-46\/index.html"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1581"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1080\/10273660008833060"},{"key":"ref68","author":"Miller, RG","year":"1966","journal-title":"Simultaneous Statistical Inference"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1089\/152091503322527021"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1007\/s10462-009-9124-7"}],"container-title":["JMIR Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetes.jmir.org\/2020\/3\/e18660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:23:56Z","timestamp":1782840236000},"score":1,"resource":{"primary":{"URL":"http:\/\/diabetes.jmir.org\/2020\/3\/e18660\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":70,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2196\/18660","relation":{"has-preprint":[{"id-type":"doi","id":"10.2196\/preprints.18660","asserted-by":"object"}]},"ISSN":["2371-4379"],"issn-type":[{"value":"2371-4379","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]}}}