{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:51:59Z","timestamp":1782841919858,"version":"3.54.5"},"reference-count":26,"publisher":"JMIR Publications Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Internet Res"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Since December 2019, an outbreak of the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly in Wuhan and worldwide. However, previous studies on pregnant patients were limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to evaluate the clinical characteristics and outcomes of pregnant and nonpregnant women with COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively collected epidemiological, clinical, laboratory, imaging, management, and outcome data of 43 childbearing-age women patients (including 17 pregnant and 26 nonpregnant patients) who presented with laboratory-confirmed COVID-19 in Tongji Hospital, Wuhan, China from January 19 to March 2, 2020. Clinical outcomes were followed up to March 28, 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 43 childbearing-age women in this study, none developed a severe adverse illness or died. The median ages of pregnant and nonpregnant women were 33.0 and 33.5 years, respectively. Pregnant women had a markedly higher proportion of history exposure to hospitals within 2 weeks before onset compared to nonpregnant women (9\/17, 53% vs 5\/26, 19%, P=.02) and a lower proportion of other family members affected (4\/17, 24% vs 19\/26, 73%, P=.004). Fever (8\/17, 47% vs 18\/26, 69%) and cough (9\/17, 53% vs 12\/26, 46%) were common onsets of symptoms for the two groups. Abdominal pain (n=4, 24%), vaginal bleeding (n=1, 6%), reduced fetal movement (n=1, 6%), and increased fetal movement (n=2, 13%) were observed at onset in the 17 pregnant patients. Higher neutrophil and lower lymphocyte percent were observed in the pregnant group compared to the nonpregnant group (79% vs 56%, P&lt;.001; 15% vs 33%, P&lt;.001, respectively). In both groups, we observed an elevated concentration of high-sensitivity C-reactive protein, erythrocyte sedimentation rate, aminotransferase, and lactate dehydrogenase. Concentrations of alkaline phosphatase and D-dimer in the pregnant group were significantly higher than those of the nonpregnant group (119.0 vs 48.0 U\/L, P&lt;.001; 2.1 vs 0.3\u03bcg\/mL, P&lt;.001, respectively). Both pregnant (4\/10, 40%) and nonpregnant (8\/15, 53%) women tested positive for influenza A virus. A majority of pregnant and nonpregnant groups received antiviral (13\/17, 76% vs 25\/26, 96%) and antibiotic (13\/17, 76% vs 23\/26, 88%) therapy. Additionally, both pregnant (2\/11, 18%) and nonpregnant (2\/19, 11%) recovered women redetected positive for SARS-CoV-2 after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The epidemiology and clinical and laboratory features of pregnant women with COVID-19 were diverse and atypical, which increased the difficulty of diagnosis. Most pregnant women with COVID-19 were mild and moderate, and rarely developed severe pneumonia or severe adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/19642","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T23:12:57Z","timestamp":1595805177000},"page":"e19642","source":"Crossref","is-referenced-by-count":23,"title":["Clinical Characteristics and Outcomes of Childbearing-Age Women With COVID-19 in Wuhan: Retrospective, Single-Center 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Sharifu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-1499","authenticated-orcid":false,"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-5574","authenticated-orcid":false,"given":"Ling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0315-7866","authenticated-orcid":false,"given":"Shaoshuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"ref1","unstructured":"Report of clustering pneumonia of unknown etiology in Wuhan CityWuhan Municipal Health 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