{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:02:39Z","timestamp":1792112559032,"version":"4.4.0"},"reference-count":61,"publisher":"JMIR Publications Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Internet Res"],"abstract":"\n Background<\/jats:title>\n Anxiety symptoms in older adults are prevalent and disabling but often go untreated. Most trials on psychological interventions for anxiety in later life have examined the effectiveness of face-to-face cognitive behavioral therapy (CBT). To bridge the current treatment gap, other treatment approaches and delivery formats should also be evaluated.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study is the first to examine the effectiveness of a brief blended acceptance and commitment therapy (ACT) intervention for older adults with anxiety symptoms, compared with a face-to-face CBT intervention.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Adults aged between 55-75 years (n=314) with mild to moderately severe anxiety symptoms were recruited from general practices and cluster randomized to either blended ACT or face-to-face CBT. Assessments were performed at baseline (T0), posttreatment (T1), and at 6- and 12-month follow-ups (T2 and T3, respectively). The primary outcome was anxiety symptom severity (Generalized Anxiety Disorder-7). Secondary outcomes were positive mental health, depression symptom severity, functional impairment, presence of Diagnostic and Statistical Manual of Mental Disorders V anxiety disorders, and treatment satisfaction.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Conditions did not differ significantly regarding changes in anxiety symptom severity during the study period (T0-T1: B=.18, P=.73; T1-T2: B=\u2212.63, P=.26; T1-T3: B=\u2212.33, P=.59). Large reductions in anxiety symptom severity (Cohen d\u22650.96) were found in both conditions post treatment, and these were maintained at the 12-month follow-up. The rates of clinically significant changes in anxiety symptoms were also not different for the blended ACT group and CBT group (\u03c721=0.2, P=.68). Regarding secondary outcomes, long-term effects on positive mental health were significantly stronger in the blended ACT group (B=.27, P=.03, Cohen d=0.29), and treatment satisfaction was significantly higher for blended ACT than CBT (B=3.19, P<.001, Cohen d=0.78). No other differences between the conditions were observed in the secondary outcomes.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The results show that blended ACT is a valuable treatment alternative to CBT for anxiety in later life.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Netherlands Trial Register TRIAL NL6131 (NTR6270); https:\/\/www.trialregister.nl\/trial\/6131<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/24366","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T10:02:56Z","timestamp":1616752976000},"page":"e24366","source":"Crossref","is-referenced-by-count":45,"title":["Blended Acceptance and Commitment Therapy Versus Face-to-face Cognitive Behavioral Therapy for Older Adults With Anxiety Symptoms in Primary Care: Pragmatic Single-blind Cluster Randomized 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